Background: Separation methods of local anesthesia to diffuse and vascular must significantly affect the
clinical effect of adrenaline containing local anesthetic (mepivacaine). The aim of this prospective, randomized,
controlled studies µAde was to compare the degree of anesthesia of intact upper lateral incisor the cartridge ¼ 3%
mepivacain without epinephrine in the group after the infiltration and after intraligamentary anesthesia (ILA) in
the experimental group.
Methods: Anesthesia performed computer syringe Sleeper One 86 subjects aged 20-23 years. In all cases, aspiration
was performed. With pulp tester IVN-01 measured the pain threshold incisors and canines in microamperes during
the anesthetic effect.
Results: Reference level of all researched teeth (86 subjects) was ranged from 1 to 10 µA. Uniform pain threshold
increase to 95 (±20) µA by 5 min. watched during infiltration anesthesia then this value gradually descended to
reference level (by 20 min.). Peak single increase of pain threshold to 55 (±8,9) µA occurred immediately after
1st minute of ILA, then this value subsequently drops to reference level (10 µA) by 20 minutes. Difference between
groups of infiltration and intraligamentary anesthesia (ILA+ red) and (ILA – green) presented on Chart 6.
Conclusions: Infiltration anesthesia with mepivacaine without epinephrine smoothly diffusely increased the
pain threshold of the front teeth, reaching a significant, maximum effect by 5 minutes. Intraligamentary injection
immediately after administration created a peak increase in pain sensitivity at a lower level, almost without the
participation of the diffuse component.
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