Effects of PTH(1–34) on blood pressure, renal function, and hormones in essential hypertension Thealtered pattern of reactivity may counteract raised blood pressure

1997 ◽  
Vol 10 (10) ◽  
pp. 1356-1367
Author(s):  
B Jespersen
2016 ◽  
Vol 13 (4) ◽  
pp. 13-18
Author(s):  
V A Grigin ◽  
N M Danilov ◽  
Yu G Matchin ◽  
I E Chazova

Objective. To determine the possibility of radio frequency denervation of the renal arteries (RDN) in the treatment of patients with refractory essential hypertension (GRA). Materials and methods. The study included 57 patients with a diagnosis of the guide RAG. According to the results of surveys conducted by RDA was performed of 25 patients diagnosed with essential RAG. Within 12 months after the procedure was carried out monitoring of clinical blood pressure (BP), BP monitoring (ABPM), and laboratory evaluation of renal function and renal artery ultrasound. Statistical analysis was performed using Statistica 6.1 program, significant differences were recognized when p


1982 ◽  
Vol 63 (s8) ◽  
pp. 301s-303s ◽  
Author(s):  
V. M. Campes ◽  
D. Levitan ◽  
M. S. Romoff ◽  
Y. Saglikes ◽  
I. Sajo ◽  
...  

1. The effect of clonidine on the relationship between sympathetic nervous system activity and the state of sodium-volume balance was studied in 15 patients with essential hypertension and normal renal function (group 1) and in 14 patients with hypertension and mild to moderate renal failure (group 2). 2. Acutely, clonidine (200 μg) produced significant falls (P < 0.01) in mean blood pressure, plasma noradrenaline, plasma renin activity and plasma aldosterone in both groups of patients. The changes in mean blood pressure were significantly correlated (P < 0.01) with the changes in plasma noradrenaline. 3. Chronic therapy with clonidine also produced significant falls in mean blood pressure and plasma noradrenaline, but not in plasma renin activity or aldosterone. 4. Exchangeable sodium and plasma volume decreased significantly in patients of group 1 but not in patients of group 2. 5. The data indicate that sympathetic nerve activity may be important for the abnormal relationship between pressure and natriuresis in subjects with essential hypertension and normal renal function, but not in hypertensive subjects with impaired renal function.


2019 ◽  
Vol 47 (10) ◽  
pp. 4958-4967
Author(s):  
J Sveceny ◽  
J Charvat ◽  
K Hrach ◽  
M Horackova ◽  
O Schück

Objectives To evaluate the association between diastolic blood pressure (BP), measured by 24-hour ambulatory blood pressure monitoring (ABPM) and renal function in patients receiving treatment for essential hypertension. Methods In this cross-sectional study, ABPM, transthoracic echocardiography, estimated glomerular filtration rate (eGFR) on the basis of serum cystatin C (eGFRcyst) and the renal resistive index (RRI) were measured in patients with essential hypertension. Results The cohort consisted of 105 patients (39 men, 66 women), with a mean ± SD age of 58 ± 12 years who had been receiving treatment for 11 ± 8 years. 24-hour diastolic BP significantly positively correlated with eGFRcyst and negatively correlated with RRI. No correlation was observed with 24-hour systolic BP values. 24-hour diastolic BP values ≤70 mmHg were associated with eGFRcyst ≤60 ml/min/1.73 m2 (i.e., decreased GFR). Conclusion 24-hour diastolic BP values were significantly associated with markers of kidney function in patients receiving treatment for essential hypertension and values ≤70 mmHg may be associated with subnormal eGFRcyst.


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