Familial aggregation of resting blood pressure and heart rate in a sedentary population The heritage family study

The effect of thyroid status on arterial baroreflex function and autonomic contributions to resting blood pressure and heart rate (HR) were evaluated in conscious rats. Rats were rendered hyperthyroid (Hyper) or hypothyroid (Hypo) with triiodothyronine and propylthiouracil treatments, respectively. Euthyroid (Eut), Hyper, and Hypo rats were chronically instrumented to measure mean arterial pressure (MAP), HR, and lumbar sympathetic nerve activity (LSNA). Baroreflex function was evaluated with the use of a logistic function that relates LSNA or HR to MAP during infusion of phenylephrine and sodium nitroprusside. Contributions of the autonomic nervous system to resting MAP and HR were assessed by blocking autonomic outflow with trimethaphan. In Hypo rats, the arterial baroreflex curve for both LSNA and HR was shifted downward. Hypo animals exhibited blunted sympathoexcitatory and tachycardic responses to decreases in MAP. Furthermore, the data suggest that in Hypo rats, the sympathetic influence on HR was predominant and the autonomic contribution to resting MAP was greater than in Eut rats. In Hyper rats, arterial baroreflex function generally was similar to that in Eut rats. The autonomic contribution to resting MAP was not different between Hyper and Eut rats, but predominant parasympathetic influence on HR was exhibited in Hyper rats. The results demonstrate baroreflex control of LSNA and HR is attenuated in Hypo but not Hyper rats. Thyroid status alters the balance of sympathetic to parasympathetic tone in the heart, and the Hypo state increases the autonomic contributions to resting blood pressure.

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Familial aggregation of blood pressure and heart rate responses during behavioral stress.

Psychosomatic Medicine ◽

10.1097/00006842-198807000-00003 ◽

1988 ◽

Vol 50 (4) ◽

pp. 341-352 ◽

Cited By ~ 23

Author(s):

K A Matthews ◽

S B Manuck ◽

C M Stoney ◽

C J Rakaczky ◽

B S McCann ◽

...

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Familial Aggregation ◽

Behavioral Stress

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Familial aggregation of blood pressure: a population-based family study in eastern Finland

Journal of Human Hypertension ◽

10.1038/sj.jhh.1001049 ◽

2000 ◽

Vol 14 (7) ◽

pp. 441-445 ◽

Cited By ~ 33

Author(s):

RM Fuentes ◽

I-L Notkola ◽

S Shemeikka ◽

J Tuomilehto ◽

A Nissinen

Keyword(s):

Blood Pressure ◽

Family Study ◽

Familial Aggregation ◽

Population Based ◽

Eastern Finland

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Effect of walk training combined with blood flow restriction on resting heart rate variability and resting blood pressure in middle-aged men

Motriz Revista de Educação Física ◽

10.1590/s1980-6574201900020005 ◽

2019 ◽

Vol 25 (2) ◽

Author(s):

Adalberto Ferreira Junior ◽

Julio Cezar Schamne ◽

Leandro Ricardo Altimari ◽

Alexandre Hideki Okano ◽

Nilo Massaru Okuno

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Blood Flow ◽

Heart Rate Variability ◽

Blood Flow Restriction ◽

Resting Heart Rate ◽

Middle Aged ◽

Flow Restriction ◽

Resting Blood Pressure ◽

Resting Heart Rate Variability

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DIAGNOSA PENYAKIT JANTUNG PADA PONSEL MENGGUNAKAN POHON KEPUTUSAN

Jurnal Teknologi Terpadu ◽

10.54914/jtt.v1i1.30 ◽

2015 ◽

Vol 1 (1) ◽

Author(s):

Febri Maspiyanti

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Chest Pain ◽

Blood Sugar ◽

Fasting Blood Sugar ◽

Average Heart Rate ◽

Resting Blood Pressure

Berkembangnya teknologi kini dapat mempermudah seorang praktisi medis untuk mendiagnosa dengan cepat dan tepat apakah seorang pasien menderita penyakit jantung atau tidak layaknya seorang dokter spesialis jantung yang sudah berpengalaman. Hal tersebut dibutuhkan sebagai usaha dalam deteksi dini penyakit jantung. Penelitian ini bertujuan untuk mencari pola dari penyakit jantung dan membangun sebuah aplikasi mobile untuk mendeteksi penyakit jantung berdasarkan Pohon Keputusan (Pohon Keputusan). Dalam penelitian ini digunakan dataset sejumlah 294 data pasien yang terdiri dari 13 atribut dan 1 atribut sebagai kelas. Kami menggunakan age, sex, chest pain type, resting blood pressure, cholesterol, fasting blood sugar, resting ECG, average heart rate, examine induced angina, T or ST oldpeak, ST slope, number of major vessels, general heart rate sebagai input, dan sehat atau sakit sebagai output. Penelitian ini berhasil menghasilkan akurasi sebesar 81,29% dan mengimplementasikan aturan-aturan yang dihasilkan oleh Pohon Keputusan kedalam aplikasi ponsel. Kata kunci : Penyakit Jantung, Pohon Keputusan, Ponsel.

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Familial aggregation of nasal conditioning capacity

Journal of Applied Physiology ◽

10.1152/japplphysiol.00299.2007 ◽

2007 ◽

Vol 103 (3) ◽

pp. 1078-1081 ◽

Cited By ~ 7

Author(s):

Asli Sahin-Yilmaz ◽

Jayant M. Pinto ◽

Marcy de Tineo ◽

Samy Elwany ◽

Robert M. Naclerio

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Familial Aggregation ◽

Intraclass Correlation ◽

Total Water ◽

Large Variability ◽

Sibling Pairs ◽

Dry Air ◽

Water Gradient ◽

A Prospective Study

In our previous studies on nasal conditioning, we observed a large variability among individuals to condition inspired air. Although we previously investigated various physiological parameters (age, sex, nasal mucosal temperature, heart rate, blood pressure, and nasal volume) that might underlie these differences, we have been unable to explain this variability. Many proteins and molecules, which are under genetic control and could affect nasal conditioning, are involved in water transport,. In this study, we hypothesized that familial factors may contribute to the differences in nasal conditioning capacity (NCC). We performed a prospective study of 47 sibling pairs. Cold dry air was delivered to the nose, and the total water gradient (TWG) was calculated to determine the NCC. We found a highly significant intraclass correlation of 0.53 ( P < 0.0001) between sibling pairs for the TWG. These results suggest that there is a familial basis for nasal conditioning and a large enough genetic component to search for genes explaining the observed correlation.

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Familial and Individual Influences on Blood Pressure

Acta geneticae medicae et gemellologiae twin research ◽

10.1017/s0001566000006231 ◽

1986 ◽

Vol 35 (1-2) ◽

pp. 7-21 ◽

Cited By ~ 16

Author(s):

J. Sims ◽

J.K. Hewitt ◽

K.A. Kelly ◽

D. Carroll ◽

J.R. Turner

Keyword(s):

Blood Pressure ◽

Young Adult ◽

Family Study ◽

Middle Age ◽

Familial Aggregation ◽

Model Fitting ◽

Developmental Changes ◽

Present Sample ◽

Likelihood Model ◽

Apparent Reduction

AbstractAlthough familial aggregation of blood pressure is well documented, few studies have considered the changing contribution of genetic and environmental influences during adulthood. Applying maximum likelihood model fitting to blood pressure covariation in balanced pedigrees including both parents and their young adult twin offsprings (25 MZ, 32 DZ, aged between 16 and 24 years), it is shown that the increased variation in parents is explained by such developmental changes. For DBP, an apparent reduction in heritability from 68% to 38% from young adulthood to middle age results from the increasing impact of individual environmental experience (E1), with little or no influence from shared family environmental (E2). For SBP, shared environmental effects may play a part. Given the relatively small size of the present sample, the conclusions are to be seen as tentative. An augmented family study, incorporating middle aged twins and their young adult offspring, will clarify the causation of these developmental changes.

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