scholarly journals Familial aggregation of nasal conditioning capacity

2007 ◽  
Vol 103 (3) ◽  
pp. 1078-1081 ◽  
Author(s):  
Asli Sahin-Yilmaz ◽  
Jayant M. Pinto ◽  
Marcy de Tineo ◽  
Samy Elwany ◽  
Robert M. Naclerio
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Familial Aggregation ◽  
Intraclass Correlation ◽  
Total Water ◽  
Large Variability ◽  
Sibling Pairs ◽  
Dry Air ◽  
Water Gradient ◽  
A Prospective Study

In our previous studies on nasal conditioning, we observed a large variability among individuals to condition inspired air. Although we previously investigated various physiological parameters (age, sex, nasal mucosal temperature, heart rate, blood pressure, and nasal volume) that might underlie these differences, we have been unable to explain this variability. Many proteins and molecules, which are under genetic control and could affect nasal conditioning, are involved in water transport,. In this study, we hypothesized that familial factors may contribute to the differences in nasal conditioning capacity (NCC). We performed a prospective study of 47 sibling pairs. Cold dry air was delivered to the nose, and the total water gradient (TWG) was calculated to determine the NCC. We found a highly significant intraclass correlation of 0.53 ( P < 0.0001) between sibling pairs for the TWG. These results suggest that there is a familial basis for nasal conditioning and a large enough genetic component to search for genes explaining the observed correlation.

Supine position decreases the ability of the nose to warm and humidify air

2001 ◽  
Vol 91 (6) ◽  
pp. 2459-2465 ◽  
Author(s):  
Paraya Assanasen ◽  
Fuad M. Baroody ◽  
Edward Naureckas ◽  
Julian Solway ◽  
Robert M. Naclerio
Keyword(s):  
Supine Position ◽  
Healthy Subjects ◽  
Air Conditioning ◽  
Upright Position ◽  
Nasal Mask ◽  
Total Water ◽  
Nasal Turbinate ◽  
Dry Air ◽  
Air Volume ◽  
Water Gradient

We tested the hypothesis that decreasing nasal air volume (i.e., increasing nasal turbinate blood volume) improves nasal air conditioning. We performed a randomized, two-way crossover study on the conditioning capacity of the nose in six healthy subjects in the supine and upright position. Cold, dry air (CDA) was delivered to the nose via a nasal mask, and the temperature and humidity of air were measured before it entered and after it exited the nasal cavity. The total water gradient (TWG) across the nose was calculated and represents the nasal conditioning capacity. Nasal volume decreased significantly from baseline without changing the mucosal temperature when subjects were placed in the supine position ( P < 0.01). TWG in supine position was significantly lower than that in upright position ( P < 0.001). In the supine position, nasal mucosal temperature after CDA exposure was significantly lower than that in upright position ( P < 0.01). Our data show that placing subjects in the supine position decreased the ability of the nose to condition CDA compared with the upright position, in contrast to our hypothesis.

scholarly journals The QardioArm App in the Assessment of Blood Pressure and Heart Rate: Reliability and Validity Study (Preprint)

2017 ◽  
Author(s):  
Victoria Mazoteras Pardo ◽  
Marta E Losa Iglesias ◽  
José López Chicharro ◽  
Ricardo Becerro de Bengoa Vallejo
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
European Society ◽  
Intraclass Correlation ◽  
Reliability And Validity ◽  
Correlation Coefficients ◽  
Mobile App ◽  
Blood Pressure Monitor ◽  
Pressure Monitor ◽  
Mean Values

BACKGROUND Self-measurement of blood pressure is a priority strategy for managing blood pressure. OBJECTIVE The aim of this study was to evaluate the reliability and validity of blood pressure and heart rate following the European Society of Hypertension’s international validation protocol, as measured with the QardioArm, a fully automatic, noninvasive wireless blood pressure monitor and mobile app. METHODS A total of 100 healthy volunteers older than 25 years from the general population of Ciudad Real, Spain, participated in a test-retest validation study with two measurement sessions separated by 5 to 7 days. In each measurement session, seven systolic blood pressure, diastolic blood pressure, and heart rate assessments were taken, alternating between the two devices. The test device was the QardioArm and the previously validated criterion device was the Omron M3. Sessions took place at a single study site with an evaluation room that was maintained at an appropriate temperature and kept free from noises and distractions. RESULTS The QardioArm displayed very consistent readings both within and across sessions (intraclass correlation coefficients=0.80-0.95, standard errors of measurement=2.5-5.4). The QardioArm measurements corresponded closely to those from the criterion device (r>.96) and mean values for the two devices were nearly identical. The QardioArm easily passed all validation standards set by the European Society of Hypertension International Protocol. CONCLUSIONS The QardioArm mobile app has validity and it can be used free of major measurement error.

Familial aggregation of blood pressure and heart rate responses during behavioral stress.

1988 ◽  
Vol 50 (4) ◽  
pp. 341-352 ◽  
Author(s):  
K A Matthews ◽  
S B Manuck ◽  
C M Stoney ◽  
C J Rakaczky ◽  
B S McCann ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Familial Aggregation ◽  
Behavioral Stress

Familial aggregation of blood pressure weight and height among sibling pairs at school entry

1985 ◽  
Vol 38 (7) ◽  
pp. 575-580 ◽  
Author(s):  
H. Palti ◽  
A. Ramlal ◽  
B. Adler ◽  
E. Belmaker
Keyword(s):  
Blood Pressure ◽  
Familial Aggregation ◽  
School Entry ◽  
Sibling Pairs

A prospective study of familial aggregation of blood pressure in young children

1992 ◽  
Vol 45 (9) ◽  
pp. 959-969 ◽  
Author(s):  
Dawn K. Wilson ◽  
Lisa M. Klesges ◽  
Robert C. Klesges ◽  
Linda H. Eck ◽  
Catherine A. Hackett-Renner ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Young Children ◽  
Prospective Study ◽  
Familial Aggregation ◽  
A Prospective Study

scholarly journals Correlation and familial aggregation of dimensions of psychosis in affected sibling pairs from China

2008 ◽  
Vol 193 (4) ◽  
pp. 305-310 ◽  
Author(s):  
Evangelos Vassos ◽  
Pak C. Sham ◽  
Guiqing Cai ◽  
Hong Deng ◽  
Xiehe Liu ◽  
...  
Keyword(s):  
Social Adjustment ◽  
Clinical Characteristics ◽  
Familial Aggregation ◽  
Pair Correlation ◽  
Intraclass Correlation ◽  
Kappa Statistics ◽  
Global Functioning ◽  
Genetic Studies ◽  
Symptom Dimensions ◽  
Sibling Pairs

BackgroundA number of studies with conflicting results have examined the familiality of schizophrenia syndromes in Western populations.AimsThe objective of this study was to determine, using clinical data from concordant sibling pairs, whether symptom dimensions and other clinical characteristics of schizophrenia show familial aggregation and are therefore potentially useful traits in genetic studies.MethodWe measured clinical and demographic features, and symptom dimensions of schizophrenia in 137 families from China who had two or more affected members with schizophrenia. Within-sibling pair correlation was assessed with intraclass correlation coefficient and kappa statistics.ResultsGlobal functioning, positive, disorganisation and dysphoric symptoms, premorbid schizotypal and schizoid traits, premorbid social adjustment, type and age at illness onset all showed significant evidence of familial aggregation. DSM–IV schizophrenia subtypes were also found to be familial.ConclusionsThis is the first study in a large non-European population to confirm that schizophrenia dimensions and clinical characteristics show significant familiality, implying possible heritability. This supports their use in the delineation of homogeneous subsets for future genetic studies.

Predicting vasovagal syncope from heart rate and blood pressure: A prospective study in 140 subjects

Heart Rhythm ◽  
2018 ◽  
Vol 15 (9) ◽  
pp. 1404-1410 ◽  
Author(s):  
Nathalie Virag ◽  
Mark Erickson ◽  
Patricia Taraborrelli ◽  
Rolf Vetter ◽  
Phang Boon Lim ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Prospective Study ◽  
Vasovagal Syncope ◽  
A Prospective Study

scholarly journals Blood Pressure and Heart Rate Variability to Detect Vascular Dysregulation in Glaucoma

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Eva Charlotte Koch ◽  
Johanna Staab ◽  
Matthias Fuest ◽  
Katharina Witt ◽  
Andreas Voss ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Symbolic Dynamics ◽  
Primary Open Angle Glaucoma ◽  
Linear Time ◽  
Open Angle Glaucoma ◽  
Pressure Regulation ◽  
Vascular Dysregulation ◽  
A Prospective Study

Purpose. To investigate blood pressure and heart rate variability in patients with primary open-angle glaucoma (POAG) to detect disturbed blood pressure regulation.Methods. Thirty-one patients with POAG (mean age 68 ± 10 years) and 48 control subjects (mean age 66 ± 10 years) were included in a prospective study. Continuous blood pressure and heart rate were simultaneously and noninvasively recorded over 30 min (Glaucoscreen, aviant GmbH, Jena, Germany). Data were analyzed calculating univariate linear (time domain and frequency domain), nonlinear (Symbolic Dynamics, SD) and bivariate (Joint Symbolic Dynamics, JSD) indices.Results. Using nonlinear methods, glaucoma patients were separated with more parameters compared to linear methods. In POAG, nonlinear univariate indices (pW113 and pW120_Sys) were increased while the indices pTH10_Sys and pTH11_Sys reflect a reduction of dominant patterns. Bivariate indices (JSDdia29, JSDdia50, and JSDdia52; coupling between heart rate and diastolic blood pressure) were increased in POAG. The optimum set consisting of six parameters (JSDdia29, JSDdia58, pTH9_Sys, pW231, pW110_Sys and pW120_Sys) revealed a sensitivity of 83.3% and specificity of 80.6%.Conclusions. Nonlinear uni- and bivariate indices of continuous recordings of blood pressure and heart rate are altered in glaucoma. Abnormal blood pressure variability suggests disturbed autonomic regulation in patients with glaucoma.

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