Mismatch negativity amplitude and heschl's gyrus volume in first-episode schizophrenia

Background. The mismatch negativity (MMN) brainwave indexes novelty detection. MMN to infrequent pitch (pMMN) and duration (dMMN) deviants is reduced in long-term schizophrenia. Although not reduced at first psychosis, pMMN is inversely associated with left hemisphere Heschl’s gyrus (HG) gray matter volume within 1 year of first hospitalization for schizophrenia-spectrum psychosis, consistent with pathology of left primary auditory cortex early in disease course. We examined whether the relationship was present earlier, at first psychiatric contact for psychosis, and whether the same structural-functional association was apparent for dMMN. Method. Twenty-seven first-episode schizophrenia-spectrum (FESz) and 27 matched healthy comparison (HC) individuals were compared. EEG-derived pMMN and dMMN were measured by subtracting the standard tone waveform (80%) from the pitch- and duration-deviant waveforms (10% each). HG volumes were calculated from T1-weighted structural magnetic resonance imaging using Freesurfer. Results. In FESz, pMMN amplitudes at Fz were inversely associated with left HG (but not right) gray matter volumes, and dMMN amplitudes were associated significantly with left HG volumes and at trend-level with right HG. There were no structural-functional associations in HC. Conclusions. pMMN and dMMN index gray matter reduction in left hemisphere auditory cortex early in psychosis, with dMMN also marginally indexing right HG volumes. This suggest conjoint functional and structural pathology that affects the automatic detection of novelty with varying degrees of penetrance prior to psychosis. These brainwaves are sensitive biomarkers of pathology early in the psychotic disease course, and may serve as biomarkers of disease progression and as therapeutic outcome measures.

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Both volumetry and functional connectivity of Heschl's gyrus are associated with auditory P300 in first episode schizophrenia

Schizophrenia Research ◽

10.1016/j.schres.2014.10.006 ◽

2014 ◽

Vol 160 (1-3) ◽

pp. 57-66 ◽

Cited By ~ 9

Author(s):

Qian Guo ◽

Yingying Tang ◽

Hui Li ◽

Tianhong Zhang ◽

Jianqi Li ◽

...

Keyword(s):

Functional Connectivity ◽

First Episode ◽

Auditory P300 ◽

Heschl’S Gyrus ◽

Heschl's Gyrus ◽

First Episode Schizophrenia

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Pitch and Duration Mismatch Negativity Are Associated with Distinct Auditory Cortex and Inferior Frontal Cortex Volumes in the First-Episode Schizophrenia Spectrum

Schizophrenia Bulletin Open ◽

10.1093/schizbullopen/sgab005 ◽

2021 ◽

Author(s):

Mark T Curtis ◽

Brian A Coffman ◽

Dean F Salisbury

Keyword(s):

Auditory Cortex ◽

Frontal Cortex ◽

Gray Matter ◽

Mismatch Negativity ◽

First Episode ◽

The Novel ◽

Inferior Frontal Cortex ◽

Heschl’S Gyrus ◽

First Episode Schizophrenia ◽

Gray Matter Volumes

Abstract Background Pitch and duration mismatch negativity (pMMN/dMMN) are related to left Heschl’s gyrus gray matter volumes in first-episode schizophrenia (FESz). Previous methods were unable to delineate functional subregions within and outside Heschl’s gyrus. The Human Connectome Project multimodal parcellation (HCP-MMP) atlas overcomes this limitation by parcellating these functional subregions. Further, MMN has generators in inferior frontal cortex, and therefore, may be associated with inferior frontal cortex pathology. With the novel use of the HCP-MMP to precisely parcellate auditory and inferior frontal cortex, we investigated relationships between gray matter and pMMN and dMMN in FESz. Methods pMMN and dMMN were measured at Fz from 27 FESz and 27 matched healthy controls. T1-weighted MRI scans were acquired. The HCP-MMP atlas was applied to individuals, and gray matter volumes were calculated for bilateral auditory and inferior frontal cortex parcels and correlated with MMN. FDR correction was used for multiple comparisons. Results In FESz only, pMMN was negatively correlated with left medial belt in auditory cortex and area 47L in inferior frontal cortex. Duration MMN negatively correlated with the following auditory parcels: left medial belt, lateral belt, parabelt, TA2, and right A5. Further, dMMN was associated with left area 47L, right area 44, and right area 47L in inferior frontal cortex. Conclusions The novel approach revealed overlapping and distinct gray matter associations for pMMN and dMMN in auditory and inferior frontal cortex in FESz. Thus, pMMN and dMMN may serve as biomarkers of underlying pathological deficits in both similar and slightly different cortical areas.

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Reduced cortical thickness in right Heschl’s gyrus associated with auditory verbal hallucinations severity in first-episode schizophrenia

BMC Psychiatry ◽

10.1186/s12888-015-0546-2 ◽

2015 ◽

Vol 15 (1) ◽

Cited By ~ 20

Author(s):

Xudong Chen ◽

Shengxiang Liang ◽

Weidan Pu ◽

Yinnan Song ◽

Tumbwene E. Mwansisya ◽

...

Keyword(s):

Cortical Thickness ◽

First Episode ◽

Auditory Verbal Hallucinations ◽

Heschl’S Gyrus ◽

Heschl's Gyrus ◽

First Episode Schizophrenia

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Altered Heschl's gyrus duplication pattern in first-episode schizophrenia

Schizophrenia Research ◽

10.1016/j.schres.2021.09.011 ◽

2021 ◽

Vol 237 ◽

pp. 174-181

Author(s):

Tsutomu Takahashi ◽

Daiki Sasabayashi ◽

Yoichiro Takayanagi ◽

Atsushi Furuichi ◽

Mikio Kido ◽

...

Keyword(s):

First Episode ◽

Heschl’S Gyrus ◽

Heschl's Gyrus ◽

First Episode Schizophrenia

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Poster #S115 EFFECTS OF BLOCKING D2 RECEPTORS ON MISMATCH NEGATIVITY OF ANTIPSYCHOTIC NAÏVE, FIRST EPISODE SCHIZOPHRENIA PATIENTS

Schizophrenia Research ◽

10.1016/s0920-9964(14)70394-9 ◽

2014 ◽

Vol 153 ◽

pp. S130

Author(s):

Signe W. During ◽

Bob Oranje ◽

Birte Glenthøj

Keyword(s):

Mismatch Negativity ◽

D2 Receptors ◽

First Episode ◽

First Episode Schizophrenia

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Mismatch negativity at acute and post-acute phases of first-episode schizophrenia

European Archives of Psychiatry and Clinical Neuroscience ◽

10.1007/s00406-007-0772-9 ◽

2007 ◽

Vol 258 (3) ◽

pp. 179-185 ◽

Cited By ~ 37

Author(s):

Müge Devrim-Üçok ◽

H. Yasemin Keskin-Ergen ◽

Alp Üçok

Keyword(s):

Mismatch Negativity ◽

First Episode ◽

First Episode Schizophrenia

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Duration Mismatch Negativity Predicts Remission in First-Episode Schizophrenia Patients

Frontiers in Psychiatry ◽

10.3389/fpsyt.2021.777378 ◽

2021 ◽

Vol 12 ◽

Author(s):

Suguru Nakajima ◽

Yuko Higuchi ◽

Takahiro Tateno ◽

Daiki Sasabayashi ◽

Yuko Mizukami ◽

...

Keyword(s):

Social Functioning ◽

Mismatch Negativity ◽

Rating Scale ◽

Clinical Symptoms ◽

First Episode ◽

Healthy Controls ◽

Brief Assessment ◽

Syndrome Scale ◽

Symptomatic Remission ◽

First Episode Schizophrenia

Objective: Remission in schizophrenia patients is associated with neurocognitive, social, and role functioning during both the early and chronic stages of schizophrenia. It is well-established that the amplitudes of duration mismatch negativity (dMMN) and frequency MMN (fMMN) are reduced in schizophrenia patients. However, the potential link between MMN and remission has not been established. In this study, we investigated the relationship between MMNs and remission in first-episode schizophrenia (FES) and their association with neurocognitive and social functioning.Method: dMMN and fMMN were measured in 30 patients with FES and 22 healthy controls at baseline and after a mean of 3 years. Clinical symptoms and cognitive and social functioning in the patients were assessed at the time of MMN measurements by using the Positive and Negative Syndrome Scale (PANSS), modified Global Assessment of Functioning (mGAF), Schizophrenia Cognition Rating Scale (SCoRS), and the Brief Assessment of Cognition in Schizophrenia (BACS). Remission of the patients was defined using the criteria by the Remission in Schizophrenia Working Group; of the 30 patients with FES, 14 achieved remission and 16 did not.Results: Baseline dMMN amplitude was reduced in FES compared to healthy controls. Further, baseline dMMN in the non-remitters had decreased amplitude and prolonged latency compared to the remitters. MMN did not change during follow-up period regardless of parameters, diagnosis, or remission status. Baseline dMMN amplitude in FES was correlated with future SCoRS and PANSS total scores. Logistic regression analysis revealed that dMMN amplitude at baseline was a significant predictor of remission.Conclusions: Our findings suggest that dMMN amplitude may be a useful biomarker for predicting symptomatic remission and improvement of cognitive and social functions in FES.

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