P01.137 Neurological abnormalities in African-Caribbean and white British first-episode psychosis patients

BackgroundAfrican-Caribbean and black African people living in the UK are reported to have a higher incidence of diagnosed psychosis compared with white British people. It has been argued that this may be a consequence of misdiagnosis. If this is true they might be less likely to show the patterns of structural brain abnormalities reported in white British patients. The aim of this study therefore was to investigate whether there are differences in the prevalence of structural brain abnormalities in white and black first-episode psychosis patients.MethodWe obtained dual-echo (proton density/T2-weighted) images from a sample of 75 first-episode psychosis patients and 68 healthy controls. We used high resolution magnetic resonance imaging and voxel-based methods of image analysis. Two separate analyses were conducted: (1) 34 white British patients were compared with 33 white British controls; (2) 41 African-Caribbean and black African patients were compared with 35 African-Caribbean and black African controls.ResultsWhite British patients and African-Caribbean/black African patients had ventricular enlargement and increased lenticular nucleus volume compared with their respective ethnic controls. The African-Caribbean/black African patients also showed reduced global grey matter and increased lingual gyrus grey-matter volume. The white British patients had no regional or global grey-matter loss compared with their normal ethnic counterparts but showed increased grey matter in the left superior temporal lobe and right parahippocampal gyrus.ConclusionsWe found no evidence in support of our hypothesis. Indeed, the finding of reduced global grey-matter volume in the African-Caribbean/black African patients but not in the white British patients was contrary to our prediction.

Download Full-text

Symptom profiles and explanatory models of first-episode psychosis in African-, Caribbean- and European-origin groups in Ontario

Early Intervention in Psychiatry ◽

10.1111/eip.12272 ◽

2015 ◽

Vol 11 (2) ◽

pp. 165-170 ◽

Cited By ~ 4

Author(s):

Anika Maraj ◽

Kelly K. Anderson ◽

Nina Flora ◽

Manuela Ferrari ◽

Suzanne Archie ◽

...

Keyword(s):

First Episode Psychosis ◽

Explanatory Models ◽

First Episode ◽

European Origin ◽

Symptom Profiles ◽

Episode Psychosis ◽

African Caribbean

Download Full-text

Jumping to social conclusions?: The implications of early and uninformed social judgements in first episode psychosis.

Journal of Abnormal Psychology ◽

10.1037/abn0000490 ◽

2020 ◽

Vol 129 (1) ◽

pp. 131-141

Author(s):

Michael J. Grossman ◽

Christopher R. Bowie

Keyword(s):

First Episode Psychosis ◽

First Episode ◽

Episode Psychosis

Download Full-text

Gender differences in response to metacognitive training in people with first-episode psychosis.

Journal of Consulting and Clinical Psychology ◽

10.1037/ccp0000468 ◽

2020 ◽

Vol 88 (6) ◽

pp. 516-525 ◽

Cited By ~ 1

Author(s):

Miriam Salas-Sender ◽

Raquel López-Carrilero ◽

Ana Barajas ◽

Esther Lorente-Rovira ◽

Esther Pousa ◽

...

Keyword(s):

Gender Differences ◽

First Episode Psychosis ◽

First Episode ◽

Metacognitive Training ◽

Episode Psychosis

Download Full-text

Cognitive clusters in first-episode psychosis: Overlap with healthy controls and relationship to concurrent and prospective symptoms and functioning.

Neuropsychology ◽

10.1037/neu0000367 ◽

2017 ◽

Vol 31 (7) ◽

pp. 787-797 ◽

Cited By ~ 18

Author(s):

Jacqueline Uren ◽

Susan M. Cotton ◽

Eoin Killackey ◽

Michael M. Saling ◽

Kelly Allott

Keyword(s):

First Episode Psychosis ◽

First Episode ◽

Healthy Controls ◽

Episode Psychosis

Download Full-text

Improving outcomes: Factors influencing help-seeking behaviors in immigrants and ethnic minorities with first-episode psychosis

Die Psychiatrie ◽

10.1055/s-0038-1672286 ◽

2016 ◽

Vol 13 (03) ◽

pp. 152-157

Author(s):

A. O. Berg ◽

K. Leopold ◽

S. Zarafonitis-Müller ◽

M. Nerhus ◽

L. H. Stouten ◽

...

Keyword(s):

Mental Health ◽

Help Seeking ◽

Service Use ◽

First Episode Psychosis ◽

Pathways To Care ◽

First Episode ◽

Factors Influencing ◽

Increased Risk ◽

Episode Psychosis ◽

The Hague

Summary Background: Immigrants have increased risk of a poor recovery from first episode psychosis (FEP). Early treatment can improve prognosis, but having an immigrant background may influence pathways to care. Method: We present research of service use and factors influencing treatment outcome in immigrants with FEP. Service use was assessed in in-patients at an early intervention center in Berlin, Germany. Duration of untreated psychosis and beliefs about illness was assessed in a FEP study in Oslo, Norway and cognitive functioning in patients with FEP schizophrenia from the regular mental health services in The Hague, the Netherlands. The proportion of immigrants in Berlin and Oslo was at level with the local populations, while the proportion in The Hague appeared to be higher. Result: There were clear indications that mental health literacy, probably based in different cultural expectations, were lower in first generation immigrants (FGI). Findings regarding clinical insight were ambiguous. There were also indications that FGI had more cognitive problems, based in higher stress levels or in cognitive styles. Early psychosis services must take issues of immigration and ethnicity into consideration.

Download Full-text