Directional Persistence in the Rewarded Alternation Model of Obsessive-compulsive Disorder is Responsive to both Dopaminergic and Serotonergic Manipulations

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
D. Kontis ◽  
V. Boulougouris ◽  
S. Papadopoulos ◽  
V.-M. Papakosta ◽  
S. Kalogerakou ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Low Dose ◽  
Receptor Activation ◽  
Common Mechanism ◽  
High Dose ◽  
List Type ◽  
Type Number ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Serotonin Agonist

Rationale:In the rewarded alternation model of obsessive compulsive disorder (OCD), the serotonin agonist m-chlorophenylpiperazine (mCPP) increases persistent behaviour, while chronic pretreatment with selective serotonin reuptake inhibitor (SSRI-fluoxetine) but not benzodiazepine or desipramine abolishes mCPP effects. However, we noted that acute SSRI administration also causes transient persistence increases, counteracted by mCPP pretreatment.Objectives:This studya.further explores the apparent cross-tolerance between fluoxetine and mCPP andb.extends the model by investigating its sensitivity to dopaminergic manipulations (D2,3 agonism - quinpirole).Methods:In both experiments, baseline and drug testing was carried out under daily T-maze alternation training.Exp.1:Matched group (n=8) pairs of rats received one of the following 20-day pretreatments (daily intraperitoneal administration):1.saline,2.low-dose fluoxetine (2.5mg/kg),3.low-dose mCPP (0.5mg/kg) or4.combined fluoxetine+mCPP.One group per pretreatment then received a 4-day challenge with high-dose fluoxetine (10mg/kg), the other with high-dose mCPP (2.5mg/kg).Exp.2:One group (n=12) of rats received 20-day treatment with saline, another with quinpirole (0.5 mg/kg).Results:Exp.1:Saline and low-dose mCPP- or fluoxetine-pretreated animals showed significant persistence increases under both challenges, while combined low-dose fluoxetine+mCPP pretreatment afforded full protection from either challenge.Exp.2:Quinpirole significantly increased directional persistence after 13 administration days.Conclusions:These results establish the sensitivity of the rewarded alternation OCD model to D2,3receptor activation, thereby extending its profile of pharmacological isomorphism with OCD. Furthermore, they suggest a common mechanism of action of an SSRI and a serotonin agonist in the control of directional persistence.

The effectiveness of high-dose escitalopram in the treatment of patients suffering from schizophrenia with comorbid obsessive-compulsive disorder

2019 ◽  
Vol 34 (4) ◽  
pp. 179-183 ◽  
Author(s):  
Dafna Sara Rubin-Kahana ◽  
Assaf Shelef ◽  
Abraham Weizman ◽  
Doron Gothelf ◽  
Igor Timinski ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
High Dose ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

Cultural competency in the treatment of obsessive-compulsive disorder: practitioner guidelines

2020 ◽  
Vol 13 ◽  
Author(s):  
Monnica T. Williams ◽  
Traleena M. Rouleau ◽  
Joseph T. La Torre ◽  
Noor Sharif
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Behavioural Therapy ◽  
Explanatory Models ◽  
Basic Knowledge ◽  
List Type ◽  
Cultural Groups ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Critical Skills ◽  
Race Ethnicity

Abstract This article provides clinical guidelines for basic knowledge and skills essential for successful work with clients who have obsessive-compulsive disorder (OCD) across ethnic, racial and religious differences. We emphasise multiculturalist and anti-racist approaches and the role of culture in shaping the presentation of OCD in clients. Several competencies are discussed to help clinicians differentiate between behaviour that is consistent with group norms versus behaviour that is excessive and psychopathological in nature. Symptom presentation, mental health literacy and explanatory models may differ across cultural groups. The article also highlights the possibility of violating client beliefs and values during cognitive behavioural therapy (CBT), and subsequently offers strategies to mitigate such problems, such as consulting community members, clergy, religious scholars and other authoritative sources. Finally, there is a discussion of how clinicians can help clients from diverse populations overcome a variety of obstacles and challenges faced in the therapeutic context, including stigma and cultural mistrust. Key learning aims (1) To gain knowledge needed for working with clients with OCD across race, ethnicity and culture. (2) To understand how race, ethnicity and culture affect the assessment and treatment of OCD. (3) To increase awareness of critical skills needed to implement CBT effectively for OCD in ethnoracially diverse clients. (4) To acknowledge potential barriers experienced by minoritized clients and assist in creating accessible spaces for services.

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