P6.048 Patient functional status/quality of life, safety,and tolerability with long-term modafinil in chronic shiftwork sleep disorder

2004 ◽  
Vol 14 ◽  
pp. S376-S377
Author(s):  
T. Roth ◽  
C.A. Czeisler ◽  
M.K. Erman ◽  
J.K. Walsh ◽  
J.R.L. Schwartz ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Functional Status ◽  
Sleep Disorder ◽  
Life Safety

Spinal Cord Stimulation Is Effective in Management of Complex Regional Pain Syndrome I: Fact or Fiction

Neurosurgery ◽  
2011 ◽  
Vol 69 (3) ◽  
pp. 566-580 ◽  
Author(s):  
Krishna Kumar ◽  
Syed Rizvi ◽  
Sharon Bishop Bnurs
Keyword(s):  
Quality Of Life ◽  
Spinal Cord ◽  
Functional Status ◽  
Complex Regional Pain Syndrome ◽  
Spinal Cord Stimulation ◽  
Pain Syndrome ◽  
Sf 36

Abstract BACKGROUND: Complex regional pain syndrome (CRPS) I is a debilitating neuropathic pain disorder characterized by burning pain and allodynia. Spinal cord stimulation (SCS) is effective in the treatment of CRPS I in the medium term but its long-term efficacy and ability to improve functional status remains controversial. OBJECTIVE: To evaluate the ability of SCS to improve pain, functional status, and quality of life in the long term. METHODS: We retrospectively analyzed 25 patients over a mean follow-up period of 88 months. The parameters for evaluation were visual analog scale (VAS), Oswestry Disability Index (ODI), Beck Depression Inventory (BDI), EuroQoL-5D (EQ-5D) and Short Form 36 (SF-36), and drug consumption. Evaluations were conducted at point of entry, 3 months, 12 months, and last follow-up at 88 months (mean). RESULTS: At baseline, the mean scores were VAS 8.4, ODI 70%, BDI 28, EQ-5D 0.30, and SF-36 24. In general, maximum improvement was recorded at follow-up at 3 months (VAS 4.8, ODI 45%, BDI 15, EQ-5D 0.57, and SF-36 45). At last follow-up, scores were 5.6, 50%, 19, 0.57, and 40, respectively. Despite some regression, at last follow-up benefits were maintained and found to be statistically significant (P < .001) compared with baseline. Medication usage declined. SCS did not prevent disease spread to other limbs. Best results were achieved in stage I CRPS I, patients under 40 years of age, and those receiving SCS within 1 year of disease onset. CONCLUSION: SCS improves pain, quality of life, and functional status over the long term and consequently merits early consideration in the treatment continuum.

Functional status and quality of life in long-term survivors of cardiac arrest after cardiac surgery

2001 ◽  
Vol 29 (7) ◽  
pp. 1408-1411 ◽  
Author(s):  
Ioanna Dimopoulou ◽  
Anastasia Anthi ◽  
Alkis Michalis ◽  
George E. Tzelepis
Keyword(s):  
Quality Of Life ◽  
Cardiac Arrest ◽  
Cardiac Surgery ◽  
Functional Status ◽  
Long Term Survivors

scholarly journals Long-term functional status and quality of life after lower extremity revascularization

1999 ◽  
Vol 29 (3) ◽  
pp. 395-402 ◽  
Author(s):  
Jeremy Holtzman ◽  
Michael Caldwell ◽  
Craig Walvatne ◽  
Robert Kane
Keyword(s):  
Quality Of Life ◽  
Lower Extremity ◽  
Functional Status ◽  
Lower Extremity Revascularization

scholarly journals Factors influencing outcomes in patients with stroke

Medicina ◽  
2007 ◽  
Vol 43 (4) ◽  
pp. 269 ◽  
Author(s):  
Eglė Milinavičienė ◽  
Daiva Rastenytė ◽  
Aleksandras Kriščiūnas
Keyword(s):  
Quality Of Life ◽  
Urinary Incontinence ◽  
Cognitive Function ◽  
Functional Status ◽  
Functional Recovery ◽  
Effective Utilization ◽  
Factors Influencing ◽  
Initial Severity

Outcomes of stroke result in long-term disability in most of the patients. It has been confirmed by scientific studies that rehabilitation can improve functional status and quality of life of poststroke patients. The effectiveness of rehabilitation and the outcomes often differ among patients. For effective utilization of the rehabilitation resources, it is important to prognosticate the possible outcomes of the disorder. Recently, studies are performed with the aim to determine and evaluate factors possibly influencing functional recovery in poststroke patients and helping to distinguish patients with good outcome from those with poor outcome. Age, gender, initial severity of the stroke, functional status at admission to hospital, urinary incontinence, impairment in cognitive function, unilateral neglect syndrome are most often analyzed in scientific studies as factors determining the outcomes of the disorder.

scholarly journals Sex differences in long-term quality of life after stroke: influence of mood and functional status

2020 ◽  
Vol 35 (7) ◽  
pp. 470-478
Author(s):  
F. López Espuela ◽  
J.C. Portilla Cuenca ◽  
C. Leno Díaz ◽  
J.M. Párraga Sánchez ◽  
G. Gamez-Leyva ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Sex Differences ◽  
Functional Status

Chronic non-cancer pain and the long-term efficacy and safety of opioids: Some blind men and an elephant?

2012 ◽  
Vol 3 (1) ◽  
pp. 5-13 ◽  
Author(s):  
C. Peter ◽  
N. Watson
Keyword(s):  
Quality Of Life ◽  
Adverse Effects ◽  
Cancer Pain ◽  
Functional Status ◽  
Efficacy And Safety ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

AbstractBackgroundThe use of opioids for chronic non-cancer pain (CNCP) remains very controversial. There are a number of randomized controlled trials (RCTs) showing efficacy and safety in the short-term, but long-term data are limited.MethodsThis article contains 10 case reports (followed to 2011) that were selected from a survey of 84 patients with intractable CNCP treated with opioids and followed every 3 months now for a median of 10 years. The previous published survey of this group reported outcomes of pain severity, adverse effects, pain relief, satisfaction, mood, problematic opioid use, tolerance, physical dependency, functional status, health-related quality of life (HRQL), immune status and sexual function. The outcome measures for that study included a numerical rating scale (NRS) for pain, Hospital Anxiety and Depression Scale (HADS), the Brief Pain Inventory Interference Scale (BPI-I), the Pain Disability Index (PDI), and for Health Related Quality of Life (HRQL) the Short Form Health Survey 12 version 2 (SF12v2). These selected patient reports were chosen to illustrate some important aspects of the diagnostic categories of CNCP, the opioids and doses used, particular issues (concurrent addiction history, bipolar disorder, and combination therapy), disease-specific and other outcomes (pain severity and relief, adverse effects, mood, function) and duration of follow-up with complex pain problems.ResultsOpioids were found to be safe and effective in the long-term for these particular patients, as well as in the larger group from which they originate. Most patients in the total sample reported 50% or greater relief and a moderate improvement in disability. Scores for functional status and HRQL were not severely affected (PDI and BPI-I ratings moderate or less and SF12v2 slightly below normative values for age). Problematic use, tolerance, and serious adverse effects including constipation were not major issues.ConclusionThese 10 reports of patients with intractable CNCP treated with opioids with some success over many years put a face on some of the participants in the larger survey of 84 suggesting that this approach is effective and safe for some patients over many years.ImplicationsThese data may not be generalizable to a larger population of patients with CNCP because of the probable selection of patients who benefit and who do not have intolerable adverse effects.

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