Effects of Steviol on renal function and mean arterial pressure in rats

The novel environment of a metabolic cage can be stressful for rodents, but few studies have attempted to quantify this stressresponse. Therefore, we determined the effects on mean arterial pressure (MAP) and heart rate (HR), of placing mice of both sexes in metabolism cages for 2 days. After surgical implantation of a carotid artery catheter mice recovered individually in standard cages for 5 days. Mice then spent 2 days in metabolism cages. MAP and HR were monitored in the standard cage on Day 5 and in metabolism cages on Days 6-7. MAP increased by 18±3 and 22±4 %, while HR increased by 27±4 and 27±6 %, in males and females, respectively, during the first hours after cage switch. MAP decreased to baseline in the fourth and eighth h following metabolism cage switch in males and females, respectively. However, HR remained significantly elevated in both sexes during the entire two-day period in metabolism cages. Females had lower MAP than males both pre- and postmetabolism cage switch, but there were no sex differences in HR. These results demonstrate sustained changes in cardiovascular function when mice are housed in metabolism cages, which could potentially affect renal function.

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Increasing mean arterial pressure in patients with septic shock: Effects on oxygen variables and renal function*

Critical Care Medicine ◽

10.1097/01.ccm.0000157788.20591.23 ◽

2005 ◽

Vol 33 (4) ◽

pp. 780-786 ◽

Cited By ~ 230

Author(s):

Aurélie Bourgoin ◽

Marc Leone ◽

Anne Delmas ◽

Franck Garnier ◽

Jacques Albanèse ◽

...

Keyword(s):

Septic Shock ◽

Renal Function ◽

Mean Arterial Pressure ◽

Arterial Pressure

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Relation between mean arterial pressure and renal function in the early phase of shock: a prospective, explorative cohort study

Critical Care ◽

10.1186/cc10253 ◽

2011 ◽

Vol 15 (3) ◽

pp. R135 ◽

Cited By ~ 92

Author(s):

Julie Badin ◽

Thierry Boulain ◽

Stephan Ehrmann ◽

Marie Skarzynski ◽

Anne Bretagnol ◽

...

Keyword(s):

Renal Function ◽

Cohort Study ◽

Mean Arterial Pressure ◽

Arterial Pressure ◽

Early Phase

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Increasing Mean Arterial Pressure in Patients With Septic Shock: Effects on Oxygen Variables and Renal Function

Yearbook of Critical Care Medicine ◽

10.1016/s0734-3299(08)70134-5 ◽

2006 ◽

Vol 2006 ◽

pp. 180-182

Author(s):

A. Shannah ◽

S.L. Zanotti-Cavazzoni

Keyword(s):

Septic Shock ◽

Renal Function ◽

Mean Arterial Pressure ◽

Arterial Pressure

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Chronic elevation of renal venous pressure induces extensive renal venous collateral formation and modulates renal function and cardiovascular stability in rats

AJP Renal Physiology ◽

10.1152/ajprenal.00542.2019 ◽

2020 ◽

Vol 319 (1) ◽

pp. F76-F83

Author(s):

Shereen M. Hamza ◽

Xiaohua Huang ◽

Tayyaba Zehra ◽

Wenqing Zhuang ◽

William A. Cupples ◽

...

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Renal Function ◽

Mean Arterial Pressure ◽

Arterial Pressure ◽

Venous Pressure ◽

Similar Degree ◽

Sham Operation ◽

Baseline Renal Function ◽

Collateral Formation

Acutely increased renal venous pressure (RVP) impairs renal function, but the long-term impact is unknown. We investigated whether chronic RVP elevation impairs baseline renal function and prevents exacerbation of renal dysfunction and cardiovascular instability upon further RVP increase. RVP elevation (20–25 mmHg) or sham operation (sham) was performed in rats. After 1 wk ( n = 17) or 3 wk ( n = 22), blood pressure, RVP, renal blood flow (RBF), renal vascular conductance (RVC), and glomerular filtration rate (GFR) were measured at baseline and during superimposed RVP increase. Chronic RVP elevation induced extensive renal venous collateral formation. RVP fell to 6 ± 1 mmHg at 1 wk and 3 ± 1 mmHg at 3 wk. Baseline blood pressure and heart rate were unaltered compared with sham. RBF, RVC, and GFR were reduced at 1 wk but normalized by 3 wk. Upon further RVP increase, the drop in mean arterial pressure was attenuated at 3 wk compared with 1 wk ( P < 0.05), whereas heart rate fell comparably across all groups; the mean arterial pressure-heart rate relationship was disrupted at 1 and 3 wk. RBF fell to a similar degree as sham at 1 wk (−2.3 ± 0.7 vs. −3.9 ± 1.2 mL/min, P = 0.066); however, at 3 wk, this was attenuated compared with sham (−1.5 ± 0.5 vs. −4.2 ± 0.7 mL/min, P < 0.05). The drop in RVC and GFR was attenuated at 1 and 3 wk ( P < 0.05). Thus, chronic RVP elevation induced by partial renal vein ligation elicits extensive renal venous collateral formation, and although baseline renal function is impaired, chronic RVP elevation in this manner induces protective adaptations in kidneys of healthy rats, which attenuates the hemodynamic response to further RVP increase.

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Effects of the enantiomers of a new dihydropyridine derivative, S12968 and S12967, on renal functions in rats

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y93-127 ◽

1993 ◽

Vol 71 (10-11) ◽

pp. 848-853

Author(s):

José M. López-Novoa ◽

Inmaculada Montañés

Keyword(s):

Blood Flow ◽

Renal Function ◽

Glomerular Filtration Rate ◽

Mean Arterial Pressure ◽

Arterial Pressure ◽

Glomerular Filtration ◽

Renal Blood Flow ◽

Filtration Rate ◽

Renal Plasma Flow ◽

Hypotensive Effect

The aim of this study was to evaluate the effects of the two enantiomers of a new dihydropyridine, S12967 and S12968, on rat renal function. Male Wistar rats were injected intravenously with saline, S12967, or S12968 (0.1, 0.3, or 1 mg/kg body weight). Urinary flow, glomerular filtration rate, renal plasma flow, urinary sodium, potassium, and calcium excretions, mean arterial pressure, and renal vascular resistance were determined before and every 30 min up to 180 min after administration of the tested substance. The levogyre enantiomer S12968, at a dose of 0.3 mg/kg, induced a 4-fold increase in urinary sodium excretion, without significant or with minor changes in glomerular filtration rate, renal plasma flow, or renal blood flow. The hypotensive effect was small and nonsignificant. At 1 mg/kg, S12968 caused a profound hypotensive effect that impaired the renal function, induced marked oliguria, and decreased glomerular filtration rate and renal blood flow to almost negligible values. The dextrogyre enantiomer S12967 had much less effect on renal function. These data showing specific stereoselective renal effects are in agreement with pharmacological studies that have demonstrated that S12968 possesses a higher affinity for the dihydropyridine-binding site than its dextrogyre enantiomer, S12967.Key words: Ca channel antagonists, dihydropyridine, glomerular filtration rate, renal blood flow, natriuresis, mean arterial pressure.

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