Activated factor XII and cerebrovascular disease: a novel risk factor for post stroke mortality

Background: anemia is known to be a risk factor for developing ischemic stroke in long-term follow-up studies, and it is also known to increase the risk of death in ischemic stroke patients. We aimed to determine the association of anemia with the risk of ischemic stroke and the risk of death after ischemic stroke. Methods: The study included patients from National Health Insurance Service cohort, from January 2005 to December 2015. Anemia patients were defined as those with confirmed diagnostic codes and related medications in the sample cohort, and patients under the age of 18 were excluded. To perform a comparative analysis with the control group, twice as many patients were extracted by propensity score matching. The effects of anemia on the development of ischemic stroke were analyzed. Results: A total of 58,699 patients were newly diagnosed with anemia during the study period. In anemia group, the rate of ischemic stroke occurring within 1 year was 0.550%, and the rate was 0.272% in the control group. The odds ratio of anemia related to ischemic stroke was 1.602 (95% confidence intervals (CI) 1.363–1.883). During the follow-up period, 175 out of 309 (56.6%) died in anemia group, and 130 out of 314 (41.4%) died in control group. The anemia group showed a higher risk of death than the control group (Hazard ratio 1.509, 95% CI 1.197–1.902). Conclusion: Analysis of the nationwide health insurance data revealed that anemia is one of the risk factors for the development of ischemic stroke, and also an independent prognostic factor affecting post-stroke mortality.

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Mild hyponatremia discovered within the first 24 hours of ischemic stroke is a risk factor for early post stroke mortality

Advances in Clinical and Experimental Medicine ◽

10.17219/acem/103070 ◽

2019 ◽

Vol 28 (10) ◽

pp. 1321-1327

Author(s):

Agnieszka Gala-Błądzińska ◽

Jolanta Czarnota ◽

Rafał Kaczorowski ◽

Marcin Braun ◽

Krzysztof Gargasz ◽

...

Keyword(s):

Risk Factor ◽

Ischemic Stroke ◽

Stroke Mortality ◽

Post Stroke

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Blood Pressure Lowering in Patients With Cerebrovascular Disease: Results of the Randomized Post-stroke Antihypertensive Treatment Study (PATS)

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)84622-0 ◽

1998 ◽

Vol 31 (2) ◽

pp. 211A ◽

Cited By ~ 3

Author(s):

L Liu

Keyword(s):

Blood Pressure ◽

Cerebrovascular Disease ◽

Antihypertensive Treatment ◽

Blood Pressure Lowering ◽

Post Stroke ◽

Pressure Lowering

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Association between apolipoprotein gene polymorphisms and hyperlipidemia: a meta-analysis

BMC Genomic Data ◽

10.1186/s12863-021-00968-1 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Xiao-Ning Zhao ◽

Quan Sun ◽

You-Qin Cao ◽

Xiao Ran ◽

Yu Cao

Keyword(s):

Risk Factor ◽

Cerebrovascular Disease ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Control Group ◽

Case Group ◽

Healthy Controls ◽

Ε4 Allele ◽

Different Populations ◽

The Impact

Abstract Background Hyperlipidemia plays an important role in the etiology of cardio-cerebrovascular disease. Over recent years, a number of studies have explored the impact of apolipoprotein genetic polymorphisms in hyperlipidemia, but considerable differences and uncertainty have been found in their association with different populations from different regions. Results A total of 59 articles were included, containing in total 13,843 hyperlipidemia patients in the case group and 15,398 healthy controls in the control group. Meta-analysis of the data indicated that APOA5–1131 T > C, APOA1 -75 bp, APOB XbaI, and APOE gene polymorphisms were significantly associated with hyperlipidemia, with OR values of 1.996, 1.228, 1.444, and 1.710, respectively. All P-values were less than 0.05. Conclusions Meta-analysis of the data indicated that the C allele of APOA5 1131 T > C, the A allele at APOA1-75 bp, the APOB XbaI T allele, and the ε2 and ε4 allele of APOE were each a risk factor for susceptibility for hyperlipidemia.

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