Trail induced apoptosis and interaction with cytotoxic agents in soft tissue sarcoma cell lines

2001 ◽  
Vol 37 ◽  
pp. S111
Author(s):  
Sandra Tomek ◽  
Wolfgang Koestler ◽  
Thomas Brodowicz ◽  
Ingrid Pribill ◽  
Alexandra Budinsky ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Cell Lines ◽  
Cytotoxic Agents ◽  
Sarcoma Cell ◽  
Induced Apoptosis

Trail-induced apoptosis and interaction with cytotoxic agents in soft tissue sarcoma cell lines

2003 ◽  
Vol 39 (9) ◽  
pp. 1318-1329 ◽  
Author(s):  
S Tomek ◽  
W Koestler ◽  
P Horak ◽  
T Grunt ◽  
T Brodowicz ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Cell Lines ◽  
Cytotoxic Agents ◽  
Sarcoma Cell ◽  
Induced Apoptosis

Biologic activities of trail in soft tissue sarcoma cell lines: induction of apoptosis and interaction with cytotoxic agents

2001 ◽  
Vol 37 ◽  
pp. S85
Author(s):  
S. Tomek ◽  
T. Brodowicz ◽  
W. Koestler ◽  
I. Pribill ◽  
A. Peffer ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Cell Lines ◽  
Cytotoxic Agents ◽  
Sarcoma Cell ◽  
Induction Of Apoptosis

scholarly journals Up-regulation of the DR5 Expression by Proteasome Inhibitor MG132 Augments TRAIL-Induced Apoptosis in Soft Tissue Sarcoma Cell Lines

2011 ◽  
Vol 43 (2) ◽  
pp. 124-130 ◽  
Author(s):  
Hee-Jeong Cheong ◽  
Kyu Sang Lee ◽  
In Sook Woo ◽  
Jong-Ho Won ◽  
Jae Ho Byun
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Cell Lines ◽  
Proteasome Inhibitor ◽  
Proteasome Inhibitor Mg132 ◽  
Sarcoma Cell ◽  
Induced Apoptosis

Secretion of Noncomplexed ‘Big’ (10–18 kD) Forms of Insulin-Like Growth Factor-II by 12 Soft Tissue Sarcoma Cell Lines

1999 ◽  
Vol 52 (4) ◽  
pp. 178-185 ◽  
Author(s):  
Martin W. Elmlinger ◽  
Uta Rauschnabel ◽  
Ewa Koscielniak ◽  
Karin Weber ◽  
Michael B. Ranke
Keyword(s):  
Growth Factor ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Cell Lines ◽  
Insulin Like Growth Factor ◽  
Sarcoma Cell ◽  
Factor Ii

scholarly journals Establishment and molecular characterisation of seven novel soft-tissue sarcoma cell lines

2016 ◽  
Vol 115 (9) ◽  
pp. 1058-1068 ◽  
Author(s):  
Abdulazeez Salawu ◽  
Malee Fernando ◽  
David Hughes ◽  
Malcolm W R Reed ◽  
Penella Woll ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Cell Lines ◽  
Molecular Characterisation ◽  
Sarcoma Cell

scholarly journals Oncolytic virotherapy promotes radiosensitivity in soft tissue sarcoma by suppressing anti-apoptotic MCL1 expression

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0250643
Author(s):  
Toshinori Omori ◽  
Hiroshi Tazawa ◽  
Yasuaki Yamakawa ◽  
Shuhei Osaki ◽  
Joe Hasei ◽  
...  
Keyword(s):  
Dna Damage ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Ionizing Radiation ◽  
Combination Therapy ◽  
Cell Lines ◽  
Antitumor Effect ◽  
Therapeutic Potential ◽  
Subcutaneous Xenograft ◽  
Induced Apoptosis

Soft tissue sarcoma (STS) is a rare cancer that develops from soft tissues in any part of the body. Despite major advances in the treatment of STS, patients are often refractory to conventional radiotherapy, leading to poor prognosis. Enhancement of sensitivity to radiotherapy would therefore improve the clinical outcome of STS patients. We previously revealed that the tumor-specific, replication-competent oncolytic adenovirus OBP-301 kills human sarcoma cells. In this study, we investigated the radiosensitizing effect of OBP-301 in human STS cells. The in vitro antitumor effect of OBP-301 and ionizing radiation in monotherapy or combination therapy was assessed using highly radiosensitive (RD-ES and SK-ES-1) and moderately radiosensitive (HT1080 and NMS-2) STS cell lines. The expression of markers for apoptosis and DNA damage were evaluated in STS cells after treatment. The therapeutic potential of combination therapy was further analyzed using SK-ES-1 and HT1080 cells in subcutaneous xenograft tumor models. The combination of OBP-301 and ionizing radiation showed a synergistic antitumor effect in all human STS cell lines tested, including those that show different radiosensitivity. OBP-301 was found to enhance irradiation-induced apoptosis and DNA damage via suppression of anti-apoptotic myeloid cell leukemia 1 (MCL1), which was expressed at higher levels in moderately radiosensitive cell lines. The combination of OBP-301 and ionizing radiation showed a more profound antitumor effect compared to monotherapy in SK-ES-1 (highly radiosensitive) and HT1080 (moderately radiosensitive) subcutaneous xenograft tumors. OBP-301 is a promising antitumor reagent to improve the therapeutic potential of radiotherapy by increasing radiation-induced apoptosis in STS.

Abstract 5047: Survival signal pathways as potential therapeutic targets in soft tissue sarcoma cell lines

2011 ◽  
Author(s):  
Jung Woo Han ◽  
Bo Ram Kwon ◽  
Chan Hee Park ◽  
Gui Youn Lee ◽  
Hei-Cheul Jeung ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Cell Lines ◽  
Therapeutic Targets ◽  
Signal Pathways ◽  
Sarcoma Cell ◽  
Survival Signal

scholarly journals Adenovirus-mediated p53 gene therapy in pediatric soft-tissue sarcoma cell lines: sensitization to cisplatin and doxorubicin

2004 ◽  
Vol 12 (4) ◽  
pp. 397-406 ◽  
Author(s):  
Hooman Ganjavi ◽  
Matthew Gee ◽  
Aru Narendran ◽  
Melvin H Freedman ◽  
David Malkin
Keyword(s):  
Gene Therapy ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Cell Lines ◽  
P53 Gene ◽  
Sarcoma Cell
Sign in / Sign up

Export Citation Format

Share Document