Mutation and Protein Expression Biomarkers Correlate with Response to AKT Inhibition in a Phase I Trial of the Oral Pan AKT Inhibitor GSK2141795 (GSK795) in Patients (pts) with Platinum Resistant Ovarian Cancer

2011 ◽  
Vol 47 ◽  
pp. 12-13 ◽  
Author(s):  
H. Gunqor ◽  
E. Stronach ◽  
E. Curry ◽  
A. Saleem ◽  
R. Agarwal ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Protein Expression ◽  
Phase I ◽  
Phase I Trial ◽  
Akt Inhibitor ◽  
Platinum Resistant

The PACOVAR-trial: A multicenter phase I trial of pazopanib (GW786034) and metronomic cyclophosphamide in patients with recurrent platinum-resistant ovarian cancer.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 5557-5557 ◽  
Author(s):  
Michael Hans Robert Eichbaum ◽  
Marcus Schmidt ◽  
Eva-Maria Grischke ◽  
Gerhard Gebauer ◽  
Hans-Christian Fricke ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Phase I ◽  
Phase I Trial ◽  
Multicenter Phase ◽  
Platinum Resistant ◽  
Metronomic Cyclophosphamide

Abstract B273: A phase I trial of topotecan and sorafenib for patients with recurrent, platinum‐resistant epithelial ovarian cancer

2009 ◽  
Author(s):  
Daniela E. Matei ◽  
Jeanne Schilder ◽  
Susan Perkins ◽  
Mohammad Khan ◽  
Cynthia Calley ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Phase I ◽  
Epithelial Ovarian Cancer ◽  
Phase I Trial ◽  
Platinum Resistant

scholarly journals Phase I Trial of the PARP Inhibitor Olaparib and AKT Inhibitor Capivasertib in Patients with BRCA1/2- and Non–BRCA1/2-Mutant Cancers

2020 ◽  
Vol 10 (10) ◽  
pp. 1528-1543 ◽  
Author(s):  
Timothy A. Yap ◽  
Rebecca Kristeleit ◽  
Vasiliki Michalarea ◽  
Stephen J. Pettitt ◽  
Joline S.J. Lim ◽  
...  
Keyword(s):  
Phase I ◽  
Phase I Trial ◽  
Parp Inhibitor ◽  
Akt Inhibitor

scholarly journals Phase I Trial of Intraperitoneal Pemetrexed, Cisplatin, and Paclitaxel in Optimally Debulked Ovarian Cancer

2012 ◽  
Vol 18 (9) ◽  
pp. 2668-2678 ◽  
Author(s):  
Setsuko K. Chambers ◽  
H-H. Sherry Chow ◽  
Mike F. Janicek ◽  
Janiel M. Cragun ◽  
Kenneth D. Hatch ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Phase I ◽  
Phase I Trial
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