Background:
Amongst various cancer diseases, breast cancer is frequently diagnosed malignancy
in women. Existing treatments are inadequate, painful and toxic. New ways of treatments need to
be explored.
Methods:
The present work proposes preparation and targeted delivery of a formulation, F-1, for MCF-7
breast cancer treatment. The formulation, colloidal silver (0.76 ppm), was prepared by electrolytic deposition
technique and multi surface coatings. Black tea extract (2.25%v/v) was used as a capping agent to
tune the morphology of silver nanoparticle and potato extract (6.25%v/v) as a functionalizing agent for
targeting MCF-7 breast cancer site.
Results:
Characterization results show highly pure spherical silver nanoparticles with an average particle
size of 15nm. The shift of peaks in the FTIR spectra of formulation confirms the interaction between
nanoparticles and extracts. The UV-visible peak was obtained at 525nm, a typical characteristic of silver
nanoparticles. In-vivo anti-cancer study of formulation gave a moderate therapeutic effect in Non-Obese
Diabetic Severe Combined Immune Deficiency (NOD-SCID) mice.
Conclusion:
It is observed that tumor volumes obtained in the case of Formulation-1 were moderately
inhibited from days 5 to 9. However, one of the mice in the Formulation-1 group inhibited tumor volume
to 1.52 cc similar to one of the mice of positive control group (Adriamycin 1.42cc).
Targeted Delivery of Doxorubicin Liposomes for Her-2+ Breast Cancer Treatment