Targeted Delivery of Doxorubicin Liposomes for Her-2+ Breast Cancer Treatment

Resumen Los avances recientes en el campo de la biología molecular y la secuenciación del genoma se han traducido en una nueva clasificación del cáncer de mama, que busca mayor precisión y se correlaciona mejor con el riesgo de recaída de la enfermedad y la respuesta al tratamiento. Establece cuatro subtipos de cáncer de mama: luminal A, luminal B, HER 2 positivo y triple negativo, siendo el subtipo luminal A el de mejor pronóstico, y el triple negativo, el de peor pronóstico. Si combinamos la clasificación clásica histológica con la nueva molecular, nos permite encuadrar a estas pacientes de una forma más precisa en función del riesgo, definiendo así un manejo terapéutico adaptado.

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Chitosan-gold nanocarrier for targeted delivery of anti MUC1: Opportunity for breast cancer treatment

European Journal of Cancer ◽

10.1016/s0959-8049(18)30515-x ◽

2018 ◽

Vol 92 ◽

pp. S96

Author(s):

F. Dashtestani ◽

L. Farahmand ◽

N. Jalili ◽

K. Majidzadeh-A

Keyword(s):

Breast Cancer ◽

Cancer Treatment ◽

Targeted Delivery ◽

Breast Cancer Treatment

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Targeted Delivery of Colloidal Silver for MCF-7 Breast Cancer Treatment

Current Drug Delivery ◽

10.2174/1567201817666200508095241 ◽

2020 ◽

Vol 17 (7) ◽

pp. 613-621

Author(s):

Shweta Rajawat ◽

Manzar M. Malik

Keyword(s):

Breast Cancer ◽

Silver Nanoparticles ◽

Cancer Treatment ◽

Targeted Delivery ◽

Breast Cancer Treatment ◽

Cancer Site ◽

Electrolytic Deposition ◽

Average Particle ◽

Colloidal Silver ◽

Mcf 7

Background: Amongst various cancer diseases, breast cancer is frequently diagnosed malignancy in women. Existing treatments are inadequate, painful and toxic. New ways of treatments need to be explored. Methods: The present work proposes preparation and targeted delivery of a formulation, F-1, for MCF-7 breast cancer treatment. The formulation, colloidal silver (0.76 ppm), was prepared by electrolytic deposition technique and multi surface coatings. Black tea extract (2.25%v/v) was used as a capping agent to tune the morphology of silver nanoparticle and potato extract (6.25%v/v) as a functionalizing agent for targeting MCF-7 breast cancer site. Results: Characterization results show highly pure spherical silver nanoparticles with an average particle size of 15nm. The shift of peaks in the FTIR spectra of formulation confirms the interaction between nanoparticles and extracts. The UV-visible peak was obtained at 525nm, a typical characteristic of silver nanoparticles. In-vivo anti-cancer study of formulation gave a moderate therapeutic effect in Non-Obese Diabetic Severe Combined Immune Deficiency (NOD-SCID) mice. Conclusion: It is observed that tumor volumes obtained in the case of Formulation-1 were moderately inhibited from days 5 to 9. However, one of the mice in the Formulation-1 group inhibited tumor volume to 1.52 cc similar to one of the mice of positive control group (Adriamycin 1.42cc).

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