Power of Topoisomerase II-alfa (TOPO2A) as a prognostic factor for Luminal B-like breast cancer at low expression of tumor infiltrating lymphocytes (TILs)

2018 ◽  
Vol 92 ◽  
pp. S132
Author(s):  
C. Honda ◽  
A. Katayama ◽  
S. Kurozumi ◽  
T. Fujii ◽  
H. Tokiniwa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factor ◽  
Topoisomerase Ii ◽  
Tumor Infiltrating Lymphocytes ◽  
Luminal B ◽  
Infiltrating Lymphocytes ◽  
Low Expression

Impact of malnutrition and anemia at diagnosis in both: Pathological response and tumor-infiltrating-lymphocytes post neoadjuvant chemotherapy.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e12654-e12654
Author(s):  
Katia MERCEDES Roque ◽  
Marco Galvez Nino ◽  
Carlos Arturo Castaneda Altamirano ◽  
Miluska Castillo Garcia ◽  
Joselyn Sanchez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Histological Grade ◽  
Tumor Infiltrating Lymphocytes ◽  
Pathological Response ◽  
Breast Cancer Patients ◽  
Long Term Outcomes ◽  
Luminal B ◽  
Infiltrating Lymphocytes

e12654 Background: The response after neoadjuvant chemotherapy (NAC) is the main prognostic factor in breast cancer (BC), likewise, malnutrition, anemia and systemic inflammation have also been associated to prognosis in breast cancer. We evaluated the association between pathological response (PR) and tumor infiltrating lymphocytes (TILs) post NAC with nutritional predictors as body mass index (BMI), prognostic nutritional index (PNI), anemia and neutrophil/lymphocyte index (N/L). Methods: This is a retrospective analysis of women diagnosed with BC between 2006 to 2017 at Instituto Nacional de Enfermedades (INEN) who received NAC. Pathological response was classified through residual cancer burden (RCB) and TILs post NAC which were prospectively evaluated by a pathologist. Clinical and pathological features as well as survival status were obtained from patient files. Results: We identified 439 women with BC who received NAC. Median age was 49 years, histological grade 3 was found in 245 patients (55.8%) and stage IIIB was the most frequent at diagnosis with 257 patients (58.5%). Luminal B subtype was the most frequent (43.7%). Rate of pCR was 10.5% and median TILs post NAC was 20%. About nutritional predictors, we use the median as a cutoff to discriminate between high and low values, for BMI was 27.5, for PNI was 56, for hemoglobin was 13.2 and for NLR was 1.84. There was no association for TILs post NAC with BMI (p = 0.38), PNI (p = 0.057) and hemoglobin (p = 0.43). We found a positive association between ILN and TILs post NAC (p = 0.001). On the other hand, we don’t found association for RCB with BMI (p = 0.45), PNI (p = 0.641), ILN (p = 0.2) and hemoglobin (p = 0.15). In the multivariate analysis, only RCB was an independent predictor for DFS (95 % CI, 87-100.5; p = 0.00001) and OS (95 % CI, 101.8-114.1; p = 0.00001). There was no association between BMI, PNI, ILN and anemia with OS and DFS. For the TILs post NAC there was a tendency to association with DFS (p = 0.07) and OS (p = 0.07). Conclusions: There are association between neutrophil/lymphocyte index with TILs after NAC. There was no association between nutritional and systemic predictors with long-term outcomes. The pathologic response is a biomarker for predicting the long-term outcomes of breast cancer patients.

scholarly journals Prognostic Significance of Tumor-infiltrating Lymphocytes in Premenopausal, Luminal Breast Cancer Treated with Adjuvant Endocrine Therapy

2020 ◽  
Author(s):  
Jing Zhang ◽  
Mustapha Abubakar ◽  
pei Yuan ◽  
Hela Koka ◽  
Lei Guo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cells ◽  
Endocrine Therapy ◽  
Cd8 T Cells ◽  
Prognostic Significance ◽  
Tumor Infiltrating Lymphocytes ◽  
Adjuvant Endocrine Therapy ◽  
Luminal Breast Cancer ◽  
Luminal B ◽  
Infiltrating Lymphocytes

Abstract BackgroundTumor-infiltrating lymphocytes (TILs) have strong prognostic values in triple-negative and HER2-enriched breast cancer, but their prognostic roles in luminal breast cancer (LBC) are less clear. Here, we assessed the overall TILs levels and CD8+ T-cells in relation to the prognosis of LBC patients from China.Methods A total of 596 patients with LBC who were premenopausal and treated with adjuvant endocrine therapy were included. Among them, 160 cases were evaluated for CD8 by immunohistochemical (IHC) staining. Whole-section hematoxilyn and eosin and IHC staining were visually assessed for stromal TILs (sTILs), stromal CD8+ T-cells (sCD8) and intratumoral CD8+ T-cells (iCD8). Multivariable Cox proportional hazards model were used to test the associations between TILs and disease-free survival (DFS) and overall survival (OS) with the adjustment of clinicopathologic characteristics and treatment. ResultsHigh sTILs (≥10%) were associated with high histologic grade (p<0.001), luminal B/HER2- (p<0.001), luminal B/HER2+ subtype (p=0.002), and high Ki67 expression (≥25%; p=0.014). Similar associations were observed for sCD8 but not for iCD8. While sTILs and sCD8 were not associated with either DFS or OS, the presence of iCD8 (≥1%) was associated with better DFS in both univariate (HR=0.51, 95%CI 0.26-0.96, p=0.042) and multivariate (HR=0.48, 95%CI 0.25-0.92, p=0.027) analyses. Similar but less significant associations were found for iCD8 and OS (adjusted HR=0.35, 95%CI 0.11-1.10, p=0.073).Conclusions Among Chinese premenopausal patients with LBC, iCD8 demonstrated suggestive associations with favorable outcomes. In contrast, although sTILs and sCD8 were associated with more aggressive tumor features, they did not appear to be associated with clinical outcomes.

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