Role of pre-existing redox profile of human macrophages on lipid synthesis and cholesteryl ester cycle in presence of native, acetylated and oxidised low density lipoprotein

2001 ◽  
Vol 77 (1) ◽  
pp. 73-81 ◽  
Author(s):  
Elena Bravo ◽  
Mariarosaria Napolitano ◽  
Roberto Rivabene
Keyword(s):  
Cholesteryl Ester ◽  
Low Density Lipoprotein ◽  
Lipid Synthesis ◽  
Density Lipoprotein ◽  
Low Density ◽  
Human Macrophages ◽  
Oxidised Low Density Lipoprotein

scholarly journals The role of lectin-like oxidised low-density lipoprotein receptor-1 in vascular pathology

2014 ◽  
Vol 11 (6) ◽  
pp. 410-418 ◽  
Author(s):  
Daniel James Shaw ◽  
Rachel Seese ◽  
Sreenivasan Ponnambalam ◽  
Ramzi Ajjan
Keyword(s):  
Monoclonal Antibodies ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Vascular Pathology ◽  
Low Density ◽  
Lipoprotein Receptor ◽  
Low Density Lipoprotein Receptor ◽  
Density Lipoprotein Receptor ◽  
Oxidised Low Density Lipoprotein

The lectin-like oxidised low-density lipoprotein receptor-1 (LOX-1) is a vascular scavenger receptor that plays a central role in the pathogenesis of atherothrombotic disease, which remains the main cause of mortality in the Western population. Recent evidence indicates that targeting LOX-1 represents a credible strategy for the management vascular disease and the current review explores the role of this molecule in the diagnosis and treatment of atherosclerosis. LOX-1-mediated pro-atherogenic effects can be inhibited by anti-LOX-1 monoclonal antibodies and procyanidins, whereas downregulation of LOX-1 expression has been achieved by antisense oligonucleotides and a specific pyrrole–imidazole polyamide. Furthermore, LOX-1 can be utilised for plaque imaging using monoclonal antibodies and even the selective delivery of anti-atherosclerotic agents employing immunoliposome techniques. Also, plasma levels of the circulating soluble form of LOX-1 levels are elevated in atherosclerosis and therefore may constitute an additional diagnostic biomarker of vascular pathology.

Changes in vimentin in human macrophages during apoptosis induced by oxidised low density lipoprotein

2001 ◽  
Vol 156 (1) ◽  
pp. 133-144 ◽  
Author(s):  
Karin Müller ◽  
Simon Dulku ◽  
Simon J Hardwick ◽  
Jeremy N Skepper ◽  
Malcolm J Mitchinson
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Human Macrophages ◽  
Oxidised Low Density Lipoprotein
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