Inducible nitric oxide synthase inhibitors of Chinese herbs. Part 2: Naturally occurring furanocoumarins

2000 ◽  
Vol 8 (12) ◽  
pp. 2701-2707 ◽  
Author(s):  
Ching-Chiung Wang ◽  
Jing-Erh Lai ◽  
Lih-Geeng Chen ◽  
Kun-Ying Yen ◽  
Ling-Ling Yang
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Chinese Herbs ◽  
Nitric Oxide Synthase Inhibitors ◽  
Naturally Occurring ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Inducible Nitric Oxide Synthase Inhibitors of Chinese Herbs III.Rheum palmatum

Planta Medica ◽  
2002 ◽  
Vol 68 (10) ◽  
pp. 869-874 ◽  
Author(s):  
Ching-Chiung Wang ◽  
Yi-Ju Huang ◽  
Lih-Geeng Chen ◽  
Lain-Tze Lee ◽  
Ling-Ling Yang
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Chinese Herbs ◽  
Nitric Oxide Synthase Inhibitors ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

scholarly journals Inducible Nitric Oxide Synthase Immunoreactivity in the Granulomatous Intestinal Lesions of Naturally Occurring Bovine Johne's Disease

2005 ◽  
Vol 42 (3) ◽  
pp. 241-249 ◽  
Author(s):  
J. Hostetter ◽  
E. Huffman ◽  
K. Byl ◽  
E. Steadham
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Johne's Disease ◽  
Johne’S Disease ◽  
Naturally Occurring ◽  
Intestinal Lesions ◽  
Granulomatous Diseases ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Inducible nitric oxide synthase (iNOS) is important in the control of a number of intracellular pathogens, including mycobacteria, and is a marker of classic macrophage activation. In human granulomatous diseases such as leprosy, a spectrum of granulomatous lesions is described, ranging from the tuberculoid to lepromatous types. Tuberculoid granulomas are associated with enhanced iNOS production and improved clinical outcomes over the lepromatous types. The aim of this study is to determine whether an association exists between morphology of bovine Johne's disease granulomas and lesion macrophage effector functions. To accomplish this, we retrospectively evaluated 24 cases of bovine Johne's disease. In each case, we recorded the predominant granuloma morphology and evaluated iNOS immunoreactivity and bacterial burden by acid-fast stains and mycobacterial immunolabeling. The results of this study demonstrate that all cases had granulomas with features most similar to the lepromatous type. This morphology correlated with heavy bacterial burdens demonstrated by acid-fast staining and mycobacterial immunoreactivity. None of the cases had high expression of iNOS in mycobacterial-positive granulomas. When iNOS immunoreactivity was identified, it was usually located near the crypts and was distinct from the granulomatous foci.

Inducible nitric oxide synthase inhibitors fromMelia azedarach var.Japonica

1999 ◽  
Vol 22 (4) ◽  
pp. 410-413 ◽  
Author(s):  
Hak Cheol Kwon ◽  
Byeong Gon Lee ◽  
Seung Hee Kim ◽  
Chil Mann Jung ◽  
Sung Youl Hong ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Nitric Oxide Synthase Inhibitors ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide
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