Transcriptional Targeting for Cancer Gene Therapy

1998 ◽  
Vol 7 (3) ◽  
pp. 565-574 ◽  
Author(s):  
Bryan M. Clary ◽  
H. Kim Lyerly
Keyword(s):  
Gene Therapy ◽  
Cancer Gene Therapy ◽  
Cancer Gene ◽  
Transcriptional Targeting

Transcriptional Targeting for Ovarian Cancer Gene Therapy

2001 ◽  
Vol 82 (2) ◽  
pp. 229-237 ◽  
Author(s):  
E. Casado ◽  
D.M. Nettelbeck ◽  
J. Gomez-Navarro ◽  
A. Hemminki ◽  
M. Gonzalez Baron ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Gene Therapy ◽  
Cancer Gene Therapy ◽  
Cancer Gene ◽  
Transcriptional Targeting

scholarly journals Transcriptional Targeting in Cancer Gene Therapy

2003 ◽  
Vol 2003 (2) ◽  
pp. 110-137 ◽  
Author(s):  
Tracy Robson ◽  
David G. Hirst
Keyword(s):  
Gene Therapy ◽  
Gene Delivery ◽  
Cancer Gene Therapy ◽  
Cancer Gene ◽  
Cancer Treatments ◽  
Transcriptional Targeting ◽  
Exogenous Agents ◽  
Therapeutic Research ◽  
Systemic Gene Delivery ◽  
Near Future

Cancer gene therapy has been one of the most exciting areas of therapeutic research in the past decade. In this review, we discuss strategies to restrict transcription of transgenes to tumour cells. A range of promoters which are tissue-specific, tumour-specific, or inducible by exogenous agents are presented. Transcriptional targeting should prevent normal tissue toxicities associated with other cancer treatments, such as radiation and chemotherapy. In addition, the specificity of these strategies should provide improved targeting of metastatic tumours following systemic gene delivery. Rapid progress in the ability to specifically control transgenes will allow systemic gene delivery for cancer therapy to become a real possibility in the near future.

Ribozyme-Mediated Breast Cancer Gene Therapy

2002 ◽  
Author(s):  
Paula M. Pitha-Rowe ◽  
Lesia Dropulic ◽  
Boro Dropulic
Keyword(s):  
Breast Cancer ◽  
Gene Therapy ◽  
Cancer Gene Therapy ◽  
Cancer Gene ◽  
Breast Cancer Gene
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