Central Effects Index — a semiquantitative method for the assessment of CNS toxicity of local anaesthetic agents in sheep

2000 ◽  
Vol 44 (3) ◽  
pp. 467-476 ◽  
Author(s):  
L.A Ladd ◽  
L.E Mather
Keyword(s):  
Local Anaesthetic ◽  
Central Effects ◽  
Anaesthetic Agents ◽  
Semiquantitative Method ◽  
Cns Toxicity

Combined Approach of QSAR and Docking Studies for the Design of Local Anaesthetic Agents

2017 ◽  
Vol 20 (3) ◽  
Author(s):  
Chunyan Zhang ◽  
Zhi Li ◽  
Jiahai Ma ◽  
Jing Zhang ◽  
Longming Zhang ◽  
...  
Keyword(s):  
Local Anaesthetic ◽  
Docking Studies ◽  
Combined Approach ◽  
Anaesthetic Agents

The Effect of Anaesthetic Agents on Platelet Function

1991 ◽  
Vol 19 (4) ◽  
pp. 495-505 ◽  
Author(s):  
N. M. Gibbs
Keyword(s):  
Platelet Aggregation ◽  
Platelet Function ◽  
Local Anaesthetic ◽  
Peak Plasma ◽  
Plasma Concentrations ◽  
Muscle Relaxants ◽  
Current Evidence ◽  
Inhibit Platelet Aggregation ◽  
Anaesthetic Agents ◽  
Thrombotic Complications

This paper reviews studies which have investigated the effect of anaesthetic agents on platelet function The results of these studies suggest that halothane is the only agent in current use which inhibits platelet function in concentrations used clinically. Nitrous oxide appears to cause only a modest inhibition, while enflurane and isoflurane appear to have minimal or negligible effects. There is no current evidence that intravenous induction agents opiates, or muscle relaxants affect platelet function. Reports indicate that local anaesthetic agents inhibit platelet aggregation, but only at concentrations far greater than peak plasma concentrations found during clinical use. Epidural anaesthesia may be associated with a reduction in platelet aggregation through a mechanism unrelated to direct local anaesthetic inhibition. The clinical significance of the effect of halothane on platelet function is not known. However, it is possible that halothane may affect bleeding or thrombotic complications in a similar manner to other ‘anti-platelet’ drugs.

Regional anaesthesia

2014 ◽  
Author(s):  
Jeremy Prout ◽  
Tanya Jones ◽  
Daniel Martin
Keyword(s):  
Local Anaesthetic ◽  
Lower Limb ◽  
Regional Anaesthesia ◽  
Anatomical Landmarks ◽  
Ultrasound Guided ◽  
Anaesthetic Agents

The regional anaesthesia chapter discusses the pharmacology of local anaesthetic agents, techniques of nerve localisation, practical aspects of ultrasound-guided blocks and the advantages and complications of regional anaesthesia. Common, and clinically useful, blocks for the upper and lower limb are described in detail with pictures of anatomical landmarks and ultrasound appearance to compliment the description. Indications, technique, volumes required and complications are described for each block.

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