The role of cyclin-dependent kinase inhibitors in the initiation of follicular growth in the mouse ovary

1998 ◽  
Vol 5 (1) ◽  
pp. 104A-104A
Author(s):  
K OKTCY ◽  
A BAYRAKCEKEN
Keyword(s):  
Kinase Inhibitors ◽  
Cyclin Dependent Kinase ◽  
Follicular Growth ◽  
Mouse Ovary

scholarly journals Biphasic Regulation of Breast Cancer Cell Growth by Progesterone: Role of the Cyclin-Dependent Kinase Inhibitors, p21 and p27Kip1

1997 ◽  
Vol 11 (11) ◽  
pp. 1593-1607 ◽  
Author(s):  
Steve D. Groshong ◽  
Gareth I. Owen ◽  
Bryn Grimison ◽  
Irene E. Schauer ◽  
Maria C. Todd ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Kinase Inhibitors ◽  
Cyclin Dependent Kinase ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth

scholarly journals Role of the Combination of Cyclin-Dependent Kinase Inhibitors (CDKI) and Radiotherapy (RT) in the Treatment of Metastatic Breast Cancer (MBC): Advantages and Risks in Clinical Practice

2021 ◽  
Vol 11 ◽  
Author(s):  
Ambrogio Gagliano ◽  
Angela Prestifilippo ◽  
Ornella Cantale ◽  
Gianluca Ferini ◽  
Giacomo Fisichella ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Metastatic Breast Cancer ◽  
Gold Standard ◽  
Kinase Inhibitors ◽  
Metastatic Breast ◽  
Cyclin Dependent Kinase ◽  
Safety And Efficacy ◽  
Definite Evidence

Targeting cell cycle has become the gold standard for metastatic breast cancer (MBC), being cyclin-dependent kinase inhibitors (CDKIs) cornerstones of its treatment, alongside radiotherapy (RT). To date, no definite evidence regarding safety and efficacy of the combination of CDKIs plus radiotherapy (RT) is currently available. Purpose of this review is to collect data in favor or against the feasibility of the association of CDKIs + RT, describing its potential adverse events. Our review shows how CDKI + RT allows an overall satisfying disease control, proving to be effective and causing a grade of toxicity mainly influenced by the site of irradiation, leaning to favourable outcomes for sites as liver, spine or brain and to poorer outcomes for thoracic lesions or sites close to viscera; controversial evidence is instead for bone treatment. Toxicity also varies from patient to patient. To sum up, our contribution enriches and enlightens a still indefinite field regarding the feasibility of CDKIs + RT, giving cues for innovative clinical management of hormone-responsive MBC.

Survival and Cell Cycle Control in Early Hematopoiesis: Role of Bcl-2, and the Cyclin Dependent Kinase Inhibitors P27 and P21

2002 ◽  
Vol 43 (1) ◽  
pp. 51-57 ◽  
Author(s):  
Maria Marone ◽  
Giuseppina Bonanno ◽  
Sergio Rutella ◽  
Giuseppe Leone ◽  
Giovanni Scambia ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Kinase Inhibitors ◽  
Cell Cycle Control ◽  
Cyclin Dependent Kinase

scholarly journals Genetic Characterization of the Role of the Cip/Kip Family of Proteins as Cyclin-Dependent Kinase Inhibitors and Assembly Factors

2014 ◽  
Vol 34 (8) ◽  
pp. 1452-1459 ◽  
Author(s):  
A. Cerqueira ◽  
A. Martin ◽  
C. E. Symonds ◽  
J. Odajima ◽  
P. Dubus ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Genetic Characterization ◽  
Cyclin Dependent Kinase ◽  
Assembly Factors

scholarly journals Role of cyclin-dependent kinase inhibitors in the growth arrest at senescence in human prostate epithelial and uroepithelial cells

Oncogene ◽  
2001 ◽  
Vol 20 (57) ◽  
pp. 8184-8192 ◽  
Author(s):  
Steven R Schwarze ◽  
Yan Shi ◽  
Vivian X Fu ◽  
Philip A Watson ◽  
David F Jarrard
Keyword(s):  
Kinase Inhibitors ◽  
Growth Arrest ◽  
Human Prostate ◽  
Cyclin Dependent Kinase ◽  
Uroepithelial Cells

scholarly journals Role of Neutrophil Apoptosis in the Resolution of Inflammation

2010 ◽  
Vol 10 ◽  
pp. 1731-1748 ◽  
Author(s):  
Driss El Kebir ◽  
János G. Filep
Keyword(s):  
Kinase Inhibitors ◽  
Tissue Injury ◽  
Control Point ◽  
Neutrophil Granulocytes ◽  
Neutrophil Apoptosis ◽  
Cyclin Dependent Kinase ◽  
Bioactive Lipids ◽  
Resolution Of Inflammation

Neutrophil granulocytes play a central role in host defense to infection and tissue injury. Their timely removal is essential for resolution of inflammation. Increasing evidence identified neutrophil apoptosis as an important control point in the development and resolution of inflammation. Delayed apoptosis and/or impaired clearance of neutrophils aggravate and prolong tissue injury. This review will focus on outside-in signals that provide survival cues for neutrophils, the hierarchy of pro- and antiapoptotic signals, and molecular targets in the antiapoptotic signaling network that can be exploited by endogenously produced bioactive lipids, such as lipoxins or pharmacological inhibitors, including cyclin-dependent kinase inhibitors, to redirect neutrophils to apoptosis in vivo, thus promoting resolution of inflammation.

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