Nitric oxide inhibition selectively increases MMP-9 activation in vitro by aortic smooth muscle cells

2000 ◽  
Vol 191 (4) ◽  
pp. S73
Author(s):  
Gilbert R Upchurch ◽  
John W Ford ◽  
Steven J Weiss ◽  
James J Mule ◽  
Michael A Marletta ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Nitric Oxide Inhibition ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Oxide Inhibition

scholarly journals Nitric oxide inhibition increases matrix metalloproteinase–9 expression by rat aortic smooth muscle cells in vitro

2001 ◽  
Vol 34 (1) ◽  
pp. 76-83 ◽  
Author(s):  
Gilbert R. Upchurch ◽  
John W. Ford ◽  
Steven J. Weiss ◽  
Brian S. Knipp ◽  
David A. Peterson ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Matrix Metalloproteinase ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Nitric Oxide Inhibition ◽  
Aortic Smooth Muscle ◽  
Metalloproteinase 9 ◽  
Oxide Inhibition

Density-dependent hyperpolarization in cultured aortic smooth muscle cells

1989 ◽  
Vol 256 (3) ◽  
pp. C644-C651 ◽  
Author(s):  
M. G. Blennerhassett ◽  
M. S. Kannan ◽  
R. E. Garfield
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Continuous Process ◽  
Primary Cultures ◽  
Muscle Cells ◽  
Sprague Dawley ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Wistar Kyoto

The membrane potential (Em) of cultured aortic smooth muscle cells from Sprague-Dawley (SD), Wistar-Kyoto (WKY), and spontaneously hypertensive (SHR) rats was measured in proliferating primary cultures. Em of SD cells in high-density cultures was -51 to -58 mV, whereas that of low-density cultures (1-2 days) was -30 mV. This difference was due to a continuous process of hyperpolarization during proliferation in culture. Em of WKY and SHR hyperpolarized similarly, from -12 to -42 and -38 mV, respectively. Hyperpolarization of Em of SD, WKY, and SHR cells was related to cell density rather than time in culture. Em may be a sensitive and significant indicator of the changes in the differentiated state expressed by proliferating smooth muscle in vitro.

Sign in / Sign up

Export Citation Format

Share Document