PSY40 SYSTEMATIC REVIEW OFTHE PSYCHOMETRIC PROPERTIES OFTHE FUNCTIONAL ASSESSMENT OF CANCER THERAPY—ANEMIA (FACT-AN) FOR ANEMIC CANCER PATIENTS

Abstract Background: The Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog) scale is a self-assessment scale validated in routine clinical practice to assess cognitive function in cancer patients. This study aimed to validate the 37-item version of FACT-Cog exploring particularly the psychometric properties of four items related to multitasking that were not previously included in the scoring algorithm and assess its correlates in Lebanese cancer patients.Methods: A cross-sectional study was carried out including 261 patients with breast, colorectal and lung cancers undergoing chemotherapy (Ethics: CEHDF1016). Validity was confirmed using a factor analyses using the principal component analysis technique with a varimax rotation. Analyses of internal consistency, “test-retest" reliability, and convergent validity were also performed. Finally, a multiple linear regression was conducted, using the total cognition scale as a dependent variable.Results: The scale had an appropriate construct validity, and items loaded on subscales with adequate sample adequacy to factor analyses outcomes. The test-retest reliability was appropriate for the total cognition score/all sub-scores except for the FACT-Cog QOL. Moreover, a weak but significant and inverse correlation between the FACT-Cog scores and patient’s pain, fatigue, anxiety and depression. Finally, better cognition functioning was noted with age and in working patients, whereas lower functioning was observed in previous smokers and in patients with ovary/brain metastasis. Conclusions: The 37-item tool is valid and reliable. Questions related to multitasking could be included in the scoring system.

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Impact of anti-cancer therapy on disease severity and mortality in cancer patients with COVID-19: a systematic review and meta-analysis

Expert Review of Anticancer Therapy ◽

10.1080/14737140.2021.1927721 ◽

2021 ◽

Author(s):

Zhixian Lin ◽

Jiangfeng Chen ◽

Sunya Han

Keyword(s):

Systematic Review ◽

Cancer Therapy ◽

Cancer Patients ◽

Disease Severity ◽

Meta Analysis ◽

Anti Cancer

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Managing Cancer and Living Meaningfully (CALM) Intervention on Chemotherapy-Related Cognitive Impairment in Breast Cancer Survivors

Integrative Cancer Therapies ◽

10.1177/1534735420938450 ◽

2020 ◽

Vol 19 ◽

pp. 153473542093845

Author(s):

Ke Ding ◽

Xiuqing Zhang ◽

Jingjing Zhao ◽

He Zuo ◽

Ziran Bi ◽

...

Keyword(s):

Breast Cancer ◽

Cognitive Impairment ◽

Psychological Distress ◽

Cognitive Function ◽

Cancer Therapy ◽

Cancer Patients ◽

Functional Assessment ◽

Breast Cancer Survivors ◽

Breast Cancer Patients ◽

Before And After

Objective: To evaluate the effectiveness and feasibility of Managing Cancer and Living Meaningfully (CALM), which is used to reduce chemotherapy-related cognitive impairment (CRCI), relieve psychological distress, and improve quality of life (QOL) in Chinese breast cancer survivors (BCs). Methods: Seventy-four BCs were enrolled in this study. All patients were randomly assigned to either the CALM group or the care as usual (CAU) group. All patients were evaluated by the Functional Assessment of Cancer Therapy–Cognitive Function (FACT-Cog), Distress Thermometer (DT), and the Functional Assessment of Cancer Therapy–Breast (FACT-B) before and after CALM or CAU application to BCs with CRCI. We compared the differences in all these scores between the CALM group and the control group and analyzed the correlation between cognitive function and QOL. Results: Compared with the CAU group, the performance of the CALM group on the FACT-Cog, DT, and FACT-B showed significant differences before and after CALM ( t = −18.909, −5.180, −32.421, P = .000, .000, .000, respectively). Finally, there was a positive correlation between cognitive function and QOL in breast cancer patients before ( r = 0.579, P = .000) and after ( r = 0.797, P = .000) treatment. Conclusions: The present results indicated that CALM has salutary effects on the improvement of cognitive impairment and QOL and relieves psychological distress in breast cancer patients, which may be due to a positive correlation between psychological distress and cognitive function or QOL.

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