Antiapoptotic activity of herpes simplex virus type 2: the role of US3 protein kinase gene

1999 ◽  
Vol 1 (8) ◽  
pp. 601-607 ◽  
Author(s):  
So Hata ◽  
A.Hajime Koyama ◽  
Hiroshi Shiota ◽  
Akio Adachi ◽  
Fumi Goshima ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Protein Kinase ◽  
Herpes Simplex Virus Type ◽  
Kinase Gene ◽  
Protein Kinase Gene ◽  
Antiapoptotic Activity ◽  
Simplex Virus

scholarly journals Phosphorylation of Cytokeratin 17 by Herpes Simplex Virus Type 2 US3 Protein Kinase

2002 ◽  
Vol 46 (10) ◽  
pp. 707-719 ◽  
Author(s):  
Takayuki Murata ◽  
Fumi Goshima ◽  
Yuji Nishizawa ◽  
Tohru Daikoku ◽  
Hiroki Takakuwa ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Protein Kinase ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Cytokeratin 17 ◽  
Simplex Virus

scholarly journals RNA-Dependent Protein Kinase Is Required for Alpha-1 Interferon Transgene-Induced Resistance to Genital Herpes Simplex Virus Type 2

2005 ◽  
Vol 79 (14) ◽  
pp. 9341-9345 ◽  
Author(s):  
Daniel J. J. Carr ◽  
Lisa Tomanek ◽  
Robert H. Silverman ◽  
Iain L. Campbell ◽  
Bryan R. G. Williams
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Protein Kinase ◽  
Genital Herpes ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Dependent Protein Kinase ◽  
Dependent Protein ◽  
Simplex Virus

ABSTRACT We investigated the mechanism of resistance to genital herpes simplex virus type 2 (HSV-2) infection in mice transfected with the murine alpha-1 interferon (IFN-α1) transgene. In situ transfection of mice with the IFN-α1 transgene resulted in an elevation in an IFN-responsive gene, RNA-dependent protein kinase (PKR), but not 2′,5′-oligoadenylate synthetases (OAS), in vaginal tissue. Coupled with the finding that mice lacking a functional PKR pathway were no longer resistant to genital HSV-2 infection following transfection with the IFN-α1 transgene in comparison to wild-type mice or mice lacking a functional OAS pathway, these results suggest that PKR is the dominant antiviral pathway activated by the IFN-α1 transgene.

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