Self-assembly of poly(ethylene glycol)-based block copolymers for biomedical applications

Abstract:: Polysarcosine (psar) is a non-ionic hydrophilic polypeptoid with numerous biologically relevant properties. Polysarcosine is poly (n-methylated glycine) and has been reported first by wesley and co-workers in the 1920s. Polysarcosine was first synthesized via ring-opening polymerization (rop) of sarcosine n-carboxyanhydride, using high-vacuum techniques. Overall, findings highlight the potential of poly(sarcosine) as an alternative corona-forming polymer to poly (ethylene glycol)-based analogues of (polymerization-induced self-assembly) pisa assemblies for use in various pharmaceutical and biomedical applications. Numerous studies suggested that such polypeptoids hold enormous potential for many biomedical applications, including protein delivery, colloidal stabilization, and nanomedicine.

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Thermoresponsive Block Copolymers of Poly(ethylene glycol) and Polyphosphoester: Thermo-Induced Self-Assembly, Biocompatibility, and Hydrolytic Degradation

Biomacromolecules ◽

10.1021/bm800808q ◽

2009 ◽

Vol 10 (1) ◽

pp. 66-73 ◽

Cited By ~ 99

Author(s):

Yu-Cai Wang ◽

Ling-Yan Tang ◽

Yang Li ◽

Jun Wang

Keyword(s):

Block Copolymers ◽

Ethylene Glycol ◽

Self Assembly ◽

Hydrolytic Degradation ◽

Poly Ethylene Glycol ◽

Poly Ethylene

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A twin-tailed tadpole-shaped amphiphilic copolymer of poly(ethylene glycol) and cyclic poly(ε-caprolactone): synthesis, self-assembly and biomedical applications

Polymer Chemistry ◽

10.1039/c8py00022k ◽

2018 ◽

Vol 9 (33) ◽

pp. 4343-4353 ◽

Cited By ~ 8

Author(s):

Yanyan Zhou ◽

Lei Li ◽

Wei Chen ◽

Dian Li ◽

Nianchen Zhou ◽

...

Keyword(s):

Ethylene Glycol ◽

Self Assembly ◽

Biomedical Applications ◽

Amphiphilic Copolymer ◽

Poly Ethylene Glycol ◽

Poly Ethylene

A tadpole-shaped amphiphilic copolymer containing cyclic PCL and two PEG tails, PEG-b-(c-PCL)-b-PEG, was rationally designed and synthesized.

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Solution Self-Assembly of Hybrid Block Copolymers Containing Poly(ethylene glycol) and Amphiphilic β-Strand Peptide Sequences

Biomacromolecules ◽

10.1021/bm049286g ◽

2005 ◽

Vol 6 (3) ◽

pp. 1310-1315 ◽

Cited By ~ 89

Author(s):

I. W. Hamley ◽

I. A. Ansari ◽

V. Castelletto ◽

H. Nuhn ◽

A. Rösler ◽

...

Keyword(s):

Block Copolymers ◽

Ethylene Glycol ◽

Self Assembly ◽

Poly Ethylene Glycol ◽

Poly Ethylene

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Synthesis and self-assembly of amphiphilic star-block copolymers consisting of polyethylene and poly(ethylene glycol) segments

Journal of Applied Polymer Science ◽

10.1002/app.38935 ◽

2013 ◽

Vol 129 (4) ◽

pp. 2216-2223 ◽

Cited By ~ 10

Author(s):

Ran Liu ◽

Zhi Yun Li ◽

Wan Juan Wang ◽

Dan Yuan ◽

Chun Feng Meng ◽

...

Keyword(s):

Block Copolymers ◽

Ethylene Glycol ◽

Self Assembly ◽

Poly Ethylene Glycol ◽

Star Block Copolymers ◽

Poly Ethylene

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Structures and Applications of Thermoresponsive Hydrogels and Nanocomposite-Hydrogels Based on Copolymers with Poly (Ethylene Glycol) and Poly (Lactide-Co-Glycolide) Blocks

Bioengineering ◽

10.3390/bioengineering6040107 ◽

2019 ◽

Vol 6 (4) ◽

pp. 107 ◽

Cited By ~ 2

Author(s):

Tomoki Maeda

Keyword(s):

Block Copolymers ◽

Ethylene Glycol ◽

Biomedical Applications ◽

Poly Lactic Acid ◽

Poly Ethylene Glycol ◽

Nanocomposite Hydrogels ◽

Regeneration Medicine ◽

Gelation Behavior ◽

Thermoresponsive Hydrogels ◽

Poly Ethylene

Thermoresponsive hydrogels showing biocompatibility and degradability have been under intense investigation for biomedical applications, especially hydrogels composed of hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly(lactic acid-co-glycolic acid) (PLGA) as first-line materials. Even though various aspects such as gelation behavior, degradation behavior, drug-release behavior, and composition effect have been studied for 20 years since the first report of these hydrogels, there are still many outputs on parameters affecting their gelation, structure, and application. In this review, the current trends of research on linear block copolymers composed of PEG and PLGA during the last 5 years (2014–2019) are summarized. In detail, this review stresses newly found parameters affecting thermoresponsive gelation, findings from structural analysis by simulation, small-angle neutron scattering (SANS), etc., progress in biomedical applications including drug delivery systems and regeneration medicine, and nanocomposites composed of block copolymers with PEG and PLGA and nanomaterials (laponite).

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