scholarly journals Effects on sister chromatid exchange frequency of polymorphisms in DNA repair gene XRCC1 in smokers

Author(s):  
Yu-Chen Lei ◽  
Shing-Jen Hwang ◽  
Chuen-Chau Chang ◽  
Hsen-Wen Kuo ◽  
Jiin-Chyuan Luo ◽  
...  
1985 ◽  
Vol 5 (4) ◽  
pp. 881-884
Author(s):  
L H Thompson ◽  
K W Brookman ◽  
J L Minkler ◽  
J C Fuscoe ◽  
K A Henning ◽  
...  

The Chinese hamster cell line mutant EM9, which has a reduced ability to repair DNA strand breaks, is noted for its highly elevated frequency of sister chromatid exchange, a property shared with cells from individuals with Bloom's syndrome. The defect in EM9 cells was corrected by fusion hybridization with normal human fibroblasts and by transfection with DNA from hybrid cells. The transformants showed normalization of sister chromatid exchange frequency but incomplete correction of the repair defect in terms of chromosomal aberrations produced by 5-bromo-2'-deoxyuridine.


1978 ◽  
Vol 12 ◽  
pp. 534-534 ◽  
Author(s):  
Alan L Schwartz ◽  
F Sessions Cole ◽  
Fred Fiedorek ◽  
Deborah Matthews ◽  
Ivan D Frantz ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document