Altered balance between matrix gelatinases (MMP-2 and MMP-9) and their tissue inhibitors in human dilated cardiomyopathy: potential role of MMP-9 in myosin-heavy chain degradation

1999 ◽  
Vol 1 (4) ◽  
pp. 337-352 ◽  
Author(s):  
Patricia Rouet-Benzineb ◽  
Jean-Marie Buhler ◽  
Patrick Dreyfus ◽  
Annick Delcourt ◽  
Richard Dorent ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Potential Role ◽  
Tissue Inhibitors

scholarly journals Mutation screening in dilated cardiomyopathy: prominent role of the beta myosin heavy chain gene

2005 ◽  
Vol 26 (8) ◽  
pp. 794-803 ◽  
Author(s):  
Eric Villard ◽  
Laetitia Duboscq-Bidot ◽  
Philippe Charron ◽  
Abdelaziz Benaiche ◽  
Viviane Conraads ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Mutation Screening ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Myosin Heavy Chain Gene

scholarly journals Immunochemical Probing of the Functional Role of the 238-246 and 567-574 Sequences of Myosin Heavy Chain

1995 ◽  
Vol 232 (1) ◽  
pp. 235-240 ◽  
Author(s):  
Edna Blotnick ◽  
Carl Miller ◽  
Ute Groschel-Stewart ◽  
Andras Muhlrad
Keyword(s):  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Functional Role

scholarly journals Calcineurin plays a modulatory role in loading-induced regulation of type I myosin heavy chain gene expression in slow skeletal muscle

2009 ◽  
Vol 297 (4) ◽  
pp. R1037-R1048 ◽  
Author(s):  
Clay E. Pandorf ◽  
Weihua H. Jiang ◽  
Anqi X. Qin ◽  
Paul W. Bodell ◽  
Kenneth M. Baldwin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Fiber Type ◽  
Hindlimb Suspension ◽  
Chain Gene ◽  
Type I ◽  
Thyroid State

The role of calcineurin (Cn) in skeletal muscle fiber-type expression has been a subject of great interest because of reports indicating that it controls the slow muscle phenotype. To delineate the role of Cn in phenotype remodeling, particularly its role in driving expression of the type I myosin heavy chain (MHC) gene, we used a novel strategy whereby a profound transition from fast to slow fiber type is induced and examined in the absence and presence of cyclosporin A (CsA), a Cn inhibitor. To induce the fast-to-slow transition, we first subjected rats to 7 days of hindlimb suspension (HS) + thyroid hormone [triiodothyronine (T3)] to suppress nearly all expression of type I MHC mRNA in the soleus muscle. HS + T3 was then withdrawn, and rats resumed normal ambulation and thyroid state, during which vehicle or CsA (30 mg·kg−1·day−1) was administered for 7 or 14 days. The findings demonstrate that, despite significant inhibition of Cn, pre-mRNA, mRNA, and protein abundance of type I MHC increased markedly during reloading relative to HS + T3 ( P < 0.05). Type I MHC expression was, however, attenuated by CsA compared with vehicle treatment. In addition, type IIa and IIx MHC pre-mRNA, mRNA, and relative protein levels were increased in Cn-treated compared with vehicle-treated rats. These findings indicate that Cn has a modulatory role in MHC transcription, rather than a role as a primary regulator of slow MHC gene expression.

Potential role of antibodies against cardiac Kv channel-interacting protein 2 in dilated cardiomyopathy

2008 ◽  
Vol 156 (1) ◽  
pp. 92-99.e2 ◽  
Author(s):  
Martin Landsberger ◽  
Alexander Staudt ◽  
Sangita Choudhury ◽  
Christiane Trimpert ◽  
Lars R. Herda ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Potential Role ◽  
Interacting Protein ◽  
Kv Channel
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