136 EFFECTS OF ETHANOL ADMINISTRATION ON LONG-TERM MEMORY DEFICIT INDUCED BY PARTIAL CHRONIC SLEEP DEPRIVATION IN MICE

2009 ◽  
Vol 10 ◽  
pp. S37
Author(s):  
L. Sanday ◽  
C.L. Patti ◽  
S.R. Kameda ◽  
M.L. Andersen ◽  
S. Tufik ◽  
...  
SLEEP ◽  
2013 ◽  
Vol 36 (4) ◽  
pp. 601-607 ◽  
Author(s):  
Christopher G. Vecsey ◽  
Mathieu E. J. Wimmer ◽  
Robbert Havekes ◽  
Alan J. Park ◽  
Isaac J. Perron ◽  
...  

SLEEP ◽  
2013 ◽  
Vol 36 (5) ◽  
pp. 751-761 ◽  
Author(s):  
Munder Zagaar ◽  
An Dao ◽  
Amber Levine ◽  
Ibrahim Alhaider ◽  
Karim Alkadhi

2020 ◽  
Vol 14 ◽  
Author(s):  
Kai Zhang ◽  
Naqi Lian ◽  
Ran Ding ◽  
Cunle Guo ◽  
Xi Dong ◽  
...  

Isoflurane contributes to cognitive deficits when used as a general anesthetic, and so does sleep deprivation (SD). Patients usually suffer from insomnia before an operation due to anxiety, fear, and other factors. It remains unclear whether preoperative SD exacerbates cognitive impairment induced by isoflurane. In this study, we observed the effects of pretreated 24-h SD in adult isoflurane-exposed mice on the cognitive behaviors, the Ca2+ signals of dorsal hippocampal CA1 (dCA1) neurons in vivo with fiber photometry, and the density of dendritic spines in hippocampal neurons. Our results showed that in cognitive behavior tasks, short-term memory damages were more severe with SD followed by isoflurane exposure than that with SD or isoflurane exposure separately, and interestingly, severe long-term memory deficits were induced only by SD followed by isoflurane exposure. Only the treatment of SD followed by isoflurane exposure could reversibly decrease the amplitude of Ca2+ signals when mice were freely moving and increase the duration of Ca2+ signals during the long-term memory behavior test. The density of dendritic spines with both SD and isoflurane exposure was lower than that with SD alone. This study suggests that SD should be avoided preoperatively in patients undergoing elective surgery under isoflurane anesthesia.


2018 ◽  
Vol 62 (4) ◽  
pp. 1887-1900 ◽  
Author(s):  
Maxime Bertoux ◽  
Emma C. Flanagan ◽  
Matthew Hobbs ◽  
Amparo Ruiz-Tagle ◽  
Carolina Delgado ◽  
...  

2021 ◽  
Vol 30 ◽  
Author(s):  
Whanhee Lee ◽  
Daeun Seo ◽  
Woojae Myung ◽  
Kristi Prifti ◽  
Cinoo Kang ◽  
...  

Abstract Aims It has been well known that air pollution and sleep deprivation individually have impacts on human health; however, the association between the two has not been well researched. The aim of this study was to investigate this relationship at a community level. Methods We collected sleep outcomes from the Korean Community Health Survey between years of 2008 and 2016. The data contained 1 130 080 selected adults aged ⩾ 19 years, from 141 communities. As sleep outcomes, annual chronic sleep deprivation (% of people who sleep ⩽ 5 h per day on average) and average values of daily mean sleep duration were used. Community-specific annual averages of particulate matter with a diameter ⩽ 10 μm (PM10), nitrogen dioxide (NO2) and carbon monoxide (CO) were collected and then applied to a linear mixed effects model to estimate the association between air pollution over the past 4 years and sleep outcomes. Population density, green space, health behaviour, and gross regional domestic product per capita variables were considered as confounders in all mixed effect models. Results From the linear mixed effect models, we found that the chronic sleep deprivation % was positively associated with PM10 (0.33% increase with 95% CI 0.05–0.60; per 10 μg/m3) and NO2 (0.68% with 95% CI 0.44–0.92; per 10 ppm). Higher PM10 and NO2 were also associated with shorter sleep duration, with a reduction of 0.37 min (95% CI −0.33 to 1.07 min; per 10 μg/m3) and 2.09 min (95% CI 1.50–2.68 min; per 10 ppm), respectively. The associations between PM10 and sleep outcomes were higher in females than males and in the older age groups (⩾ 60-years) than in younger age groups (19–39 and 40–59 years). However, the association between NO2 and sleep outcomes were more higher in males than in females and in the younger age groups (19–39 years) than other age groups. Conclusions Our findings provide epidemiological evidence that long-term interventions to reduce air pollutions are anticipated to provide improvements in sleep deficiency.


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