scholarly journals 637. Evaluation of a Reporter System for Site-Specific I-SceI-Mediated Genome Editing in Canine Hematopoietic Stem Cells

2011 ◽  
Vol 19 ◽  
pp. S244-S245
Keyword(s):  
Stem Cells ◽  
Hematopoietic Stem Cells ◽  
Genome Editing ◽  
Reporter System ◽  
Hematopoietic Stem ◽  
Site Specific

scholarly journals Non-viral ex vivo genome-editing in mouse bona fide hematopoietic stem cells with CRISPR/Cas9

2021 ◽  
Vol 20 ◽  
pp. 451-462
Author(s):  
Suvd Byambaa ◽  
Hideki Uosaki ◽  
Tsukasa Ohmori ◽  
Hiromasa Hara ◽  
Hitoshi Endo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hematopoietic Stem Cells ◽  
Genome Editing ◽  
Ex Vivo ◽  
Hematopoietic Stem ◽  
Bona Fide

scholarly journals Genome editing of HBG1 and HBG2 to induce fetal hemoglobin

2019 ◽  
Vol 3 (21) ◽  
pp. 3379-3392 ◽  
Author(s):  
Jean-Yves Métais ◽  
Phillip A. Doerfler ◽  
Thiyagaraj Mayuranathan ◽  
Daniel E. Bauer ◽  
Stephanie C. Fowler ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hematopoietic Stem Cells ◽  
Genome Editing ◽  
Globin Gene ◽  
Fetal Hemoglobin ◽  
Gene Promoters ◽  
Red Cell ◽  
Hematopoietic Stem ◽  
Key Points

Key Points Cas9 editing of the γ-globin gene promoters in hematopoietic stem cells (HSCs) increases red cell HbF by ≤40%. No deleterious effects on hematopoiesis or off-target mutations were detected 16 weeks after xenotransplantation of edited HSCs.

scholarly journals Enhanced Transduction of Human Hematopoietic Stem Cells by AAV6 Vectors: Implications in Gene Therapy and Genome Editing

2020 ◽  
Vol 20 ◽  
pp. 451-458 ◽  
Author(s):  
Hua Yang ◽  
Keyun Qing ◽  
Geoffrey D. Keeler ◽  
Ling Yin ◽  
Mario Mietzsch ◽  
...  
Keyword(s):  
Stem Cells ◽  
Gene Therapy ◽  
Hematopoietic Stem Cells ◽  
Genome Editing ◽  
Hematopoietic Stem
Sign in / Sign up

Export Citation Format

Share Document