scholarly journals 848 Relationship between N-terminal pro brain natriuretic peptide and ventricular function in patients with non-ST-elevation acute coronary syndromes

2006 ◽  
Vol 7 ◽  
pp. S136-S136
Author(s):  
M TRIVI ◽  
F BOTTO ◽  
G DALLASTA ◽  
M MORIYA ◽  
D ARAKAKI ◽  
...  
Author(s):  
Xiaocong Zeng ◽  
Lang Li ◽  
Qiang Su

AbstractPrecise risk stratification is important in patients with non-ST elevation acute coronary syndromes (NSTE-ACS) on determination for hospitalization and intensity of treatment. A meta-analysis was performed in studies of patients with NSTE-ACS to evaluate the predictive nature of elevated N-terminal pro-brain natriuretic peptide (NT-proBNP).Online searches were conducted using database to identify suitable studies. A summary of relative risks (RRs) for death and myocardial infarction (MI) was calculated using random-effects modeling. We also calculated the pooled sensitivity, specificity, positive predictive value, and negative predictive value.Thirteen studies were included. Elevated NT-proBNP levels were significantly associated with mortality [RR 4.89; 95% confidence interval (CI) 3.85–6.22] and incidence of MI (RR 1.66; 95% CI 1.24–2.22). The sensitivity and specificity for MI was 69.1% (95% CI 66.6%–71.6%) and 43.6% (95% CI 42.9%–44.3%), respectively, along with the positive and negative predictive values for MI of 8.2% (95% CI 7.7%–8.7%) and 95.1% (95% CI 94.6%–95.5%), respectively.Meta-analysis suggests that elevated NT-proBNP levels were associated with an increased risk for MI or death in patients with NSTE-ACS. Normal levels of NT-proBNP are certainly more helpful when selecting NSTE-ACS patients with likelihood for favorable outcomes.


Circulation ◽  
2004 ◽  
Vol 110 (2) ◽  
pp. 128-134 ◽  
Author(s):  
Marcello Galvani ◽  
Filippo Ottani ◽  
Luigi Oltrona ◽  
Diego Ardissino ◽  
Gian Franco Gensini ◽  
...  

2011 ◽  
Vol 13 (3) ◽  
pp. 129-135 ◽  
Author(s):  
Nikolaos I Nikolaou ◽  
Michalis J Koutouzis ◽  
Apostolos Christou ◽  
Georgios M Fournarakis ◽  
Sotirios P Patsilinakos ◽  
...  

2006 ◽  
Vol 111 (2) ◽  
pp. 224-230 ◽  
Author(s):  
Takeshi Yamamoto ◽  
Naoki Sato ◽  
Masahiro Yasutake ◽  
Hiromichi Takagi ◽  
Norishige Morita ◽  
...  

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