Abstract #1236: The Blood Turnover Markers and Parathormon Levels in Menopausal Women with Vitamin D Deficiency

ObjectiveThe objective of current study was to investigate whether associaction exist between depression and low BMD during menopausal and post-menopausal period.MethodsA cross-sectional descriptive study and 1650 women aged 45–65 years were included during 1182 women agreed to participate (71.6%). Data on body mass index (BMI), clinical biochemistry variables including serum 25-hydroxyvitamin D were collected. The Beck Depression Inventory (BDI) was administered for depression purposes.ResultsA total of 1182 women agreed to participate and responded to the study. The mean age and SD of the menopausal age were 48.71 ± 2.96 with depressed and 50.20 ± 3.22 without depressed (P < 0.001). Also, the mean and SD of postmenopausal age were 58.55 ± 3.27 depressed and 57.78 ± 3.20 without depressed (P < 0.001). There were statistically significance differences between menopausal stages with regards to number of parity, and place of living. There were statistically significance differences between menopausal stages with regards to BMI, systolic and diastolic blood pressure, vitamin D deficiency, calcium deficiency and sheesha smoking habits. Overall, osteopenia and osteoporosis and bone loss were significantly lower in post-menopausal women than in menopausal women (P < 0.001). Similarly, T-score and z-score were lower with depressed menopause and postmenopausal women (P < 0.001).ConclusionThe multivariate logistic regression analyses revealed that the depression, the mean serum vitamin D deficiency, calcium level deficiency, less physical activity, co-morbidity, number of parity, systolic and diastolic blood pressure and sheesha smoking habits were considered as the main risk factors associated with bone mineral loss after adjusting for age, BMI and other variables.Disclosure of interestThe author has not supplied his/her declaration of competing interest.

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MENOPAUSAL WOMEN, SUFFERING FROM OSTEOPENIA AND VITAMIN D DEFICIENCY

Maturitas ◽

10.1016/s0378-5122(09)70344-5 ◽

2009 ◽

Vol 63 ◽

pp. S87

Author(s):

S. Djurica ◽

M. Vuksanovic ◽

B. Zerajic

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Menopausal Women

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Vitamin D status among postmenopausal osteoporotic women: a hospital based cross-sectional study from Northern Sri Lanka.

10.21203/rs.2.18737/v3 ◽

2020 ◽

Author(s):

Navaneethakrishnan Suganthan ◽

Thirunavukarasu Kumanan ◽

Vithegi Kesavan ◽

Mahalingam Aravinthan ◽

Nadarajah Rajeshkannan

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Menopausal Women ◽

Post Menopausal

Abstract Background Vitamin D deficiency is common among post-menopausal women and it is important to treat vitamin D deficiency to prevent falls and fractures in patients with osteoporosis. Few studies examined the prevalence of vitamin D deficiency in general population of Sri Lanka but no studies to date done among post-menopausal women with osteoporosis. This is the first study of such kind conducted to evaluate the serum vitamin D levels and factors related to Vitamin D deficiency among postmenopausal women.Methodology Hospital based Cross -sectional study was conducted at the Endocrine Unit, Teaching Hospital from January to December 2018.During the study period 105 postmenopausal women registered for DEXA scan with Endocrine Unit were recruited to the study. Data collection was done by investigators and blood sample was taken from each participant by registered nursing officers and sample was analysed by using immunohistochemistry assays. Serum Vitamin D levels were categorized and data analysis was done using SPSS 26.Results Mean age of 105 postmenopausal women was 67.7 with minimum 33 and maximum 84 years. Mean Vitamin D levels were 27.5(range11.7-52.5ng/ml). Vitamin D levels were adequate in only 36.2% (95%CI: 27.4-45.7) of women, 44% had insufficient levels and deficiency was present in 19% (95%CI: 12.4-27.4) of participants. Among the 105 women 20% were vegetarian and 53% of them consuming milk on average 3 days per week, 76.2% consuming fish on average 2 days per week, 64.8% consuming egg on average 1 day per week. Furthermore seventy five participants (71.4%) reported adequate level of sun exposure (>30minutes).Commonly reported vitamin deficiency symptoms includes paraesthesia (57.1%),bone pain (55.2%), easy fatigability (54.3%), malaise (51.4%), muscle cramps (43.8%) and proximal myopathy (40.0%).Among 71(66.7%) completed bone density assessment,38% (27.3-49.7) of them showed osteoporosis range. Vertebral Z score showed a significant correlation with vitamin D level(r-0.252, P-0.034).Conclusion Prevalence of vitamin D deficiency is relatively high among the post-menopausal women with a provisional diagnosis of osteoporosis. It is essential to correct vitamin D deficiency with supplementation when initiating treatment for osteoporosis. So vitamin D testing is desirable in decision making to treat or not to treat.

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The combination of vitamin D deficiency and overweight affects muscle mass and function in older post-menopausal women

Aging Clinical and Experimental Research ◽

10.1007/s40520-018-0921-1 ◽

2018 ◽

Vol 30 (6) ◽

pp. 625-631 ◽

Cited By ~ 10

Author(s):

Francesca Gimigliano ◽

Antimo Moretti ◽

Alessandro de Sire ◽

Dario Calafiore ◽

Giovanni Iolascon

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Muscle Mass ◽

Menopausal Women ◽

Post Menopausal ◽

And Function

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CIRCULATING BONE TURNOVER MARKERS AND THEIR RELATIONSHIPS IN HEMODIALYSIS PATIENTS WITH VITAMIN D DEFICIENCY

Wiadomości Lekarskie ◽

10.36740/wlek201911202 ◽

2019 ◽

Vol 72 (11) ◽

Author(s):

Paweł Kulicki ◽

Paweł Żebrowski ◽

Antoni Sokalski ◽

Wiesław Klatko ◽

Magdalena Birecka ◽

...

Keyword(s):

Vitamin D ◽

Bone Turnover ◽

Vitamin D Deficiency ◽

Bone Turnover Markers ◽

Hemodialysis Patients ◽

Turnover Markers

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Vitamin D status among postmenopausal osteoporotic women: a hospital based cross-sectional study from Northern Sri Lanka.

10.21203/rs.2.18737/v1 ◽

2019 ◽

Author(s):

Navaneethakrishnan Suganthan ◽

Thirunavukarasu Kumanan ◽

Vithegi Kesavan ◽

Mahalingam Aravinthan ◽

Nadarajah Rajeshkannan

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Menopausal Women ◽

Post Menopausal

Abstract Background Vitamin D deficiency is common among post-menopausal women and it is important to treat vitamin D deficiency to prevent falls and fractures in patients with osteoporosis. Few studies examined the prevalence of vitamin D deficiency in general population of Sri Lanka but no studies to date done among post-menopausal women with osteoporosis. This is the first study of such kind conducted to evaluate the serum vitamin D levels and factors related to Vitamin D deficiency among postmenopausal women.Methodology Hospital based Cross -sectional study was conducted at the Endocrine Unit, Teaching Hospital from January to December 2018.During the study period 105 postmenopausal women registered for DEXA scan with Endocrine Unit were recruited to the study. Data collection was done by investigators and blood sample was taken from each participant by registered nursing officers and sample was analysed by using immunohistochemistry assays. Serum Vitamin D levels were categorized and data analysis was done using SPSS 26.Results Mean age of 105 postmenopausal women was 67.7 with minimum 33 and maximum 84 years. Mean Vitamin D levels were 27.5(range11.7-52.5ng/ml). Vitamin D levels were adequate in only 36.2% (95%CI: 27.4-45.7) of women, 44% had insufficient levels and deficiency was present in 19% (95%CI: 12.4-27.4) of participants. Among the 105 women 20% were vegetarian and 53% of them consuming milk on average 3 days per week, 76.2% consuming fish on average 2 days per week, 64.8% consuming egg on average 1 day per week. Furthermore seventy five participants (71.4%) reported adequate level of sun exposure (>30minutes).Commonly reported vitamin deficiency symptoms includes paraesthesia (57.1%),bone pain (55.2%), easy fatigability (54.3%), malaise (51.4%), muscle cramps (43.8%) and proximal myopathy (40.0%).Among 71(66.7%) completed bone density assessment,38% (27.3-49.7) of them showed osteoporosis range. Vertebral Z score showed a significant correlation with vitamin D level(r-0.252, P-0.034).Conclusion Prevalence of vitamin D deficiency is relatively high among the post-menopausal women with a provisional diagnosis of osteoporosis. It is essential to correct vitamin D deficiency with supplementation when initiating treatment for osteoporosis. So vitamin D testing is desirable in decision making to treat or not to treat.

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Vitamin D status among postmenopausal osteoporotic women: a hospital based cross-sectional study from Northern Sri Lanka.

10.21203/rs.2.18737/v2 ◽

2020 ◽

Author(s):

Navaneethakrishnan Suganthan ◽

Thirunavukarasu Kumanan ◽

Vithegi Kesavan ◽

Mahalingam Aravinthan ◽

Nadarajah Rajeshkannan

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Menopausal Women ◽

Post Menopausal

Abstract Background Vitamin D deficiency is common among post-menopausal women and it is important to treat vitamin D deficiency to prevent falls and fractures in patients with osteoporosis. Few studies examined the prevalence of vitamin D deficiency in general population of Sri Lanka but no studies to date done among post-menopausal women with osteoporosis. This is the first study of such kind conducted to evaluate the serum vitamin D levels and factors related to Vitamin D deficiency among postmenopausal women.Methodology Hospital based Cross -sectional study was conducted at the Endocrine Unit, Teaching Hospital from January to December 2018.During the study period 105 postmenopausal women registered for DEXA scan with Endocrine Unit were recruited to the study. Data collection was done by investigators and blood sample was taken from each participant by registered nursing officers and sample was analysed by using immunohistochemistry assays. Serum Vitamin D levels were categorized and data analysis was done using SPSS 26.Results Mean age of 105 postmenopausal women was 67.7 with minimum 33 and maximum 84 years. Mean Vitamin D levels were 27.5(range11.7-52.5ng/ml). Vitamin D levels were adequate in only 36.2% (95%CI: 27.4-45.7) of women, 44% had insufficient levels and deficiency was present in 19% (95%CI: 12.4-27.4) of participants. Among the 105 women 20% were vegetarian and 53% of them consuming milk on average 3 days per week, 76.2% consuming fish on average 2 days per week, 64.8% consuming egg on average 1 day per week. Furthermore seventy five participants (71.4%) reported adequate level of sun exposure (>30minutes).Commonly reported vitamin deficiency symptoms includes paraesthesia (57.1%),bone pain (55.2%), easy fatigability (54.3%), malaise (51.4%), muscle cramps (43.8%) and proximal myopathy (40.0%).Among 71(66.7%) completed bone density assessment,38% (27.3-49.7) of them showed osteoporosis range. Vertebral Z score showed a significant correlation with vitamin D level(r-0.252, P-0.034).Conclusion Prevalence of vitamin D deficiency is relatively high among the post-menopausal women with a provisional diagnosis of osteoporosis. It is essential to correct vitamin D deficiency with supplementation when initiating treatment for osteoporosis. So vitamin D testing is desirable in decision making to treat or not to treat.

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Frequency and Determinants of Vitamin D Deficiency Among Premenopausal and Postmenopausal Women: A Multicenter Study in Karachi, Pakistan

10.21203/rs.3.rs-151558/v1 ◽

2021 ◽

Author(s):

Uzma Shamsi ◽

Iqbal Azam ◽

Azra Shamsi ◽

Dua Shamsi ◽

David Callen

Keyword(s):

Public Health ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Winter Season ◽

Lower Socioeconomic Status ◽

Vigorous Exercise ◽

Younger Women ◽

Lower Socioeconomic ◽

Menopausal Women ◽

The Mean

Abstract Background: Vitamin D deficiency is becoming a serious public health problem, even in sun-drenched cities like Karachi, Pakistan. We investigated the prevalence of vitamin D deficiency VDD and its association with sociodemographic characteristics, anthropometric measures, and lifestyle factors among Pakistani women (n = 784). Methods: Face-to-face interviews were conducted to collect information from premenopausal and menopausal women and serum 25(OH)D was measured after the interview. Results: The mean age of the women was 46.2 years, and the mean 25-hydroxyvitamin D (+/- SD) levels were 22.9 ng/ml (+/-20.3). A total of 57% of women were vitamin D deficient with higher vitamin D deficiency found among premenopausal (64.7%) women compared to menopausal women (49%). Factors associated with vitamin D deficiency were lower socioeconomic status (OR 2.00; 95% CI 1.15–3.48), younger age with highest vitamin D deficiency in < 35 years of age (OR 3.11; 95% CI 1.76–5.51), and winter season (OR 1.51, 95% CI 1.07-2.15) after adjusting for multiple confounders. The use of vitamin D supplement use (OR 0.59, 95% CI 0.38-0.92) and vigorous exercise (OR 0.20, 95 % CI 0.05-0.80) was protective against vitamin D deficiency. Conclusions: The study shows a high prevalence of vitamin D deficiency, with detrimental health effects among younger women belonging to lower socioeconomic status during the winter season. The use of vitamin D supplements and vigorous exercise were protective measures. Public health campaigns are needed for education and awareness about vitamin D deficiency to improve vitamin D status for younger women living in poor environments.

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