Vitamin D status among postmenopausal osteoporotic women: a hospital based cross-sectional study from Northern Sri Lanka.

Abstract Background Vitamin D deficiency is common among post-menopausal women and it is important to treat vitamin D deficiency to prevent falls and fractures in patients with osteoporosis. Few studies examined the prevalence of vitamin D deficiency in general population of Sri Lanka but no studies to date done among post-menopausal women with osteoporosis. This is the first study of such kind conducted to evaluate the serum vitamin D levels and factors related to Vitamin D deficiency among postmenopausal women.Methodology Hospital based Cross -sectional study was conducted at the Endocrine Unit, Teaching Hospital from January to December 2018.During the study period 105 postmenopausal women registered for DEXA scan with Endocrine Unit were recruited to the study. Data collection was done by investigators and blood sample was taken from each participant by registered nursing officers and sample was analysed by using immunohistochemistry assays. Serum Vitamin D levels were categorized and data analysis was done using SPSS 26.Results Mean age of 105 postmenopausal women was 67.7 with minimum 33 and maximum 84 years. Mean Vitamin D levels were 27.5(range11.7-52.5ng/ml). Vitamin D levels were adequate in only 36.2% (95%CI: 27.4-45.7) of women, 44% had insufficient levels and deficiency was present in 19% (95%CI: 12.4-27.4) of participants. Among the 105 women 20% were vegetarian and 53% of them consuming milk on average 3 days per week, 76.2% consuming fish on average 2 days per week, 64.8% consuming egg on average 1 day per week. Furthermore seventy five participants (71.4%) reported adequate level of sun exposure (>30minutes).Commonly reported vitamin deficiency symptoms includes paraesthesia (57.1%),bone pain (55.2%), easy fatigability (54.3%), malaise (51.4%), muscle cramps (43.8%) and proximal myopathy (40.0%).Among 71(66.7%) completed bone density assessment,38% (27.3-49.7) of them showed osteoporosis range. Vertebral Z score showed a significant correlation with vitamin D level(r-0.252, P-0.034).Conclusion Prevalence of vitamin D deficiency is relatively high among the post-menopausal women with a provisional diagnosis of osteoporosis. It is essential to correct vitamin D deficiency with supplementation when initiating treatment for osteoporosis. So vitamin D testing is desirable in decision making to treat or not to treat.

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Vitamin D status among postmenopausal osteoporotic women: a hospital based cross-sectional study from Northern Sri Lanka.

10.21203/rs.2.18737/v2 ◽

2020 ◽

Author(s):

Navaneethakrishnan Suganthan ◽

Thirunavukarasu Kumanan ◽

Vithegi Kesavan ◽

Mahalingam Aravinthan ◽

Nadarajah Rajeshkannan

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Menopausal Women ◽

Post Menopausal

Abstract Background Vitamin D deficiency is common among post-menopausal women and it is important to treat vitamin D deficiency to prevent falls and fractures in patients with osteoporosis. Few studies examined the prevalence of vitamin D deficiency in general population of Sri Lanka but no studies to date done among post-menopausal women with osteoporosis. This is the first study of such kind conducted to evaluate the serum vitamin D levels and factors related to Vitamin D deficiency among postmenopausal women.Methodology Hospital based Cross -sectional study was conducted at the Endocrine Unit, Teaching Hospital from January to December 2018.During the study period 105 postmenopausal women registered for DEXA scan with Endocrine Unit were recruited to the study. Data collection was done by investigators and blood sample was taken from each participant by registered nursing officers and sample was analysed by using immunohistochemistry assays. Serum Vitamin D levels were categorized and data analysis was done using SPSS 26.Results Mean age of 105 postmenopausal women was 67.7 with minimum 33 and maximum 84 years. Mean Vitamin D levels were 27.5(range11.7-52.5ng/ml). Vitamin D levels were adequate in only 36.2% (95%CI: 27.4-45.7) of women, 44% had insufficient levels and deficiency was present in 19% (95%CI: 12.4-27.4) of participants. Among the 105 women 20% were vegetarian and 53% of them consuming milk on average 3 days per week, 76.2% consuming fish on average 2 days per week, 64.8% consuming egg on average 1 day per week. Furthermore seventy five participants (71.4%) reported adequate level of sun exposure (>30minutes).Commonly reported vitamin deficiency symptoms includes paraesthesia (57.1%),bone pain (55.2%), easy fatigability (54.3%), malaise (51.4%), muscle cramps (43.8%) and proximal myopathy (40.0%).Among 71(66.7%) completed bone density assessment,38% (27.3-49.7) of them showed osteoporosis range. Vertebral Z score showed a significant correlation with vitamin D level(r-0.252, P-0.034).Conclusion Prevalence of vitamin D deficiency is relatively high among the post-menopausal women with a provisional diagnosis of osteoporosis. It is essential to correct vitamin D deficiency with supplementation when initiating treatment for osteoporosis. So vitamin D testing is desirable in decision making to treat or not to treat.

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Vitamin D deficiency among the patients attending B. P. Koirala Institute of Health Sciences: a cross sectional study

International Journal of Scientific Reports ◽

10.18203/issn.2454-2156.intjscirep20211452 ◽

2021 ◽

Vol 7 (5) ◽

pp. 257

Author(s):

Rajendra K. Chaudhari ◽

Cosmica Shah ◽

Ananya Raman ◽

Dikshya Yadav ◽

Basanta Gelal

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Age Groups ◽

Serum Vitamin ◽

Public Health Problem ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Serum Vitamin D ◽

Vitamin D Levels

Background: Vitamin D deficiency has become a public health problem worldwide regardless to geography. Vitamin D deficiency leads to osteoporosis and also associated with metabolic syndrome, cardiovascular diseases, obesity, diabetes and autoimmune disorders. Early detection of vitamin D level in blood followed by supplementation can prevent various chronic diseases. There are limited studies of vitamin D deficiency from eastern Nepal therefore we planned to assess the prevalence of vitamin D in different age groups and gender among patients visiting at BPKIHS.Methods: This descriptive cross-sectional study was done among the patients attending Immunoassay laboratory of the BPKIHS. Based on purposive sampling technique, data of first visit of patients were taken who came for investigation of vitamin D from January to March, 2019. Serum 25 (OH) vitamin D levels were measured by CLIA method using Maglumi 2000 (Snibe Co. Ltd, Shenzhen, China).Results: A total of 2399 (73.81%) female and 851 (26.19%) males were enrolled in the study among which 66 (2.03%), 133 (4.09%) and 3051 (93.88%) were children, adolescent and adult respectively. This study revealed 61.2%, 27.6% and 11.2% patients having deficient, insufficient and sufficient level of serum vitamin D respectively. Significantly, highest percentages of adolescents were found vitamin D deficient compared to adults and children. Adolescents have shown significantly low median levels of vitamin D (p<0.001).Conclusions: Prevalence of vitamin D deficiency is higher in patients visiting BPKIHS. Comparatively higher percentage of vitamin D deficiency and low vitamin D levels are reported among adolescents compared to children and adult.

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Association between serum vitamin D levels and neuropathic pain in rheumatoid arthritis patients: A cross-sectional study

International Journal of Rheumatic Diseases ◽

10.1111/1756-185x.13160 ◽

2017 ◽

Vol 21 (2) ◽

pp. 431-439 ◽

Cited By ~ 14

Author(s):

Hilal Yesil ◽

Ulas Sungur ◽

Sedef Akdeniz ◽

Gulcan Gurer ◽

Basak Yalcın ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Vitamin D ◽

Neuropathic Pain ◽

Serum Vitamin ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Serum Vitamin D ◽

Vitamin D Levels

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Comparison of Vitamin D Levels, Bone Metabolic Marker Levels, and Bone Mineral Density among Patients with Thyroid Disease: A Cross-Sectional Study

Diagnostics ◽

10.3390/diagnostics10121075 ◽

2020 ◽

Vol 10 (12) ◽

pp. 1075

Author(s):

Masliza Hanuni Mat Ali ◽

Tuan Salwani Tuan Ismail ◽

Wan Norlina Wan Azman ◽

Najib Majdi Yaacob ◽

Norhayati Yahaya ◽

...

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Cross Sectional Study ◽

Thyroid Diseases ◽

Z Score ◽

Sectional Study ◽

Mineral Density ◽

Cross Sectional ◽

Serum Vitamin D ◽

Vitamin D Levels

Thyroid hormones have a catabolic effect on bone homeostasis. Hence, this study aimed to evaluate serum vitamin D, calcium, and phosphate and bone marker levels and bone mineral density (BMD) among patients with different thyroid diseases. This cross-sectional study included patients with underlying thyroid diseases (n = 64, hyperthyroid; n = 53 euthyroid; n = 18, hypothyroid) and healthy controls (n = 64). BMD was assessed using z-score and left hip and lumbar bone density (g/cm2). The results showed that the mean serum vitamin D Levels of all groups was low (<50 nmol/L). Thyroid patients had higher serum vitamin D levels than healthy controls. All groups had normal serum calcium and phosphate levels. The carboxy terminal collagen crosslink and procollagen type I N-terminal propeptide levels were high in hyperthyroid patients and low in hypothyroid patients. The z-score for hip and spine did not significantly differ between thyroid patients and control groups. The hip bone density was remarkably low in the hyperthyroid group. In conclusion, this study showed no correlation between serum 25(OH)D levels and thyroid diseases. The bone markers showed a difference between thyroid groups with no significant difference in BMD.

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The Association of Serum Vitamin D Deficiency and Metabolic Risk Factors in Chinese Adults with Prediabetes: A Cross-Sectional Study

Journal of Nutritional Science and Vitaminology ◽

10.3177/jnsv.65.211 ◽

2019 ◽

Vol 65 (3) ◽

pp. 211-218 ◽

Cited By ~ 2

Author(s):

Li-Qiang TIAN ◽

Wen-Qi SHI ◽

Yang ZHOU ◽

Yu-Wen ZHANG ◽

Mei-Lin ZHANG

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Cross Sectional Study ◽

Metabolic Risk ◽

Sectional Study ◽

Chinese Adults ◽

Cross Sectional ◽

Serum Vitamin D

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P1.044 A Cross-Sectional Study Comparing Serum Vitamin D Levels in Human Immunodeficiency Virus-Infected and -Uninfected Individuals

Sexually Transmitted Infections ◽

10.1136/sextrans-2013-051184.0264 ◽

2013 ◽

Vol 89 (Suppl 1) ◽

pp. A87.1-A87

Author(s):

F Yousefi ◽

F Moradpour

Keyword(s):

Vitamin D ◽

Human Immunodeficiency Virus ◽

Serum Vitamin ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Immunodeficiency Virus

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Does Vitamin D Have a Role in the Inception of Childhood Asthma? - A Comparative Cross-Sectional Study

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2021/223 ◽

2021 ◽

Vol 8 (17) ◽

pp. 1157-1162

Author(s):

Mohan Jayabal ◽

Rashmi Ramanathan ◽

Arun Kumar ◽

Pavithra Vyshnavi Yogisparan ◽

Manishankar Subramaniyam ◽

...

Keyword(s):

Vitamin D ◽

Pulmonary Function ◽

Tertiary Care ◽

Serum Vitamin ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Asthmatic Children ◽

Serum Vitamin D ◽

Vitamin D Levels

BACKGROUND Global prevalence of paediatric asthma has shown a sharp increase in last three decades. Recently vitamin D has been linked with lung function and vitamin D supplementation can lessen the acute exacerbations in asthmatic children. The purpose of the study was to compare lung parameters and vitamin D levels in asthmatic and non-asthmatic children and assess the correlation between vitamin D levels and pulmonary function parameters in children. METHODS A cross-sectional study was conducted among 40 asthmatic children and 42 healthy volunteers between the age group of 5 and 18 years attending the paediatric outpatient department (OPD) in a tertiary care centre in Coimbatore. Pulmonary functions were assessed using computerized spirometer and the serum 25-hydroxy vitamin D levels were estimated by Diazyme EZ vitamin D assay latex enhanced immunoturbidimetric method. The results were compared between asthmatics and non-asthmatics to find out the association. RESULTS The average age of the study participants was 10.5 ± 2.5 years. Lung parameters and mean vitamin D levels are reduced in asthmatics. There is a positive significant correlation between serum vitamin D levels and forced expiratory volume FEV1 / forced vital capacity (FVC) (P < 0.05, r = 0.781), and also between vitamin D and FEV1 (P < 0.05, r = 0.28). Lung parameters like FEV1, FEV1 / FVC ratio and peak expiratory flow rate (PEFR) are significantly decreased in asthmatic children. CONCLUSIONS Majority of the asthmatics have insufficient vitamin D levels than the normal peers with no asthma. Our study confirms the positive association between vitamin D and FEV1 and FEV1 / FVC ratio. KEYWORDS Vitamin D, Asthma, Pulmonary Function, Lung Parameters

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Serum vitamin D concentrations are associated with obese but not lean NAFLD: a cross-sectional study

10.21203/rs.3.rs-74825/v1 ◽

2020 ◽

Author(s):

Qinqiu Wang ◽

Xiao-ying Shi ◽

Jinghua Wang ◽

Juanwen Zhang ◽

Cheng-Fu Xu

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Cross Sectional Study ◽

Sectional Study ◽

Obese People ◽

Cross Sectional ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Lean Nafld ◽

Low Serum

Abstract Background: Low serum vitamin D concentrations have been reported to be associated with an increased risk of non-alcoholic fatty liver disease (NAFLD). However, whether slim or obese people show a similar association between vitamin D and NAFLD remains speculative. This study aimed to explore the relationship between serum vitamin D concentrations and NAFLD in lean and obese Chinese adults.Methods: This cross-sectional study included 2538 participants (1360 men and 1178 women) who underwent their health checkups at the First Affiliated Hospital of Zhejiang University School of Medicine in 2019. NAFLD was diagnosed by liver ultrasound excluding other causes. The association of serum vitamin D concentrations with NAFLD was analyzed in lean and obese participants.Results: The overall prevalence of NAFLD was 33.61% (13.10% in lean and 53.32% in obese) in this study population. The serum vitamin D levels of obese NAFLD patients were lower than that of the obese NAFLD-free controls. However, the serum vitamin D levels of lean NAFLD patients were comparable to that of the lean NAFLD-free controls. Serum vitamin D levels were negatively correlated with the prevalence of NAFLD in obese but not lean participants. Serum vitamin D levels were independently associated with the risk of NAFLD in obese participants, with an adjusted odd ratio (95% CI) of 0.986 (0.979–0.992). However, the serum vitamin D levels were not related to the risk of NAFLD in lean participants.Conclusions: Low serum vitamin D levels are associated with NAFLD in obese but not lean participants.

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