W02-O-002 The APOB-516C/T polymorphism isassociated with a more atherogenic lipid profile in males independently of the consumption of dietary fat

2005 ◽  
Vol 6 (1) ◽  
pp. 7
Author(s):  
P. Perez-Martinez ◽  
J. Lopez-Miranda ◽  
A. Lozano ◽  
J.A. Moreno ◽  
C. Bellido ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Dietary Fat ◽  
Atherogenic Lipid Profile ◽  
Atherogenic Lipid

scholarly journals Advanced Lipoprotein Analysis Shows Atherogenic Lipid Profile That Improves After Metreleptin in Patients with Lipodystrophy

2019 ◽  
Vol 3 (8) ◽  
pp. 1503-1517 ◽  
Author(s):  
Alexandra B Kinzer ◽  
Robert D Shamburek ◽  
Marissa Lightbourne ◽  
Ranganath Muniyappa ◽  
Rebecca J Brown
Keyword(s):  
Insulin Resistance ◽  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Profile ◽  
Cvd Risk ◽  
Lipoprotein Particles ◽  
Atherogenic Lipid Profile ◽  
Atherogenic Lipid

Abstract Context Patients with lipodystrophy have dyslipidemia and insulin resistance. Leptin treatment with metreleptin in lipodystrophy decreases insulin resistance and lowers triglycerides without changing high-density lipoprotein. Detailed measurement of lipoprotein particles with nuclear magnetic resonance (NMR) spectroscopy can offer insights into cardiovascular disease (CVD) risk and lipid metabolism beyond a standard lipid panel. We hypothesized that patients with lipodystrophy would have a more atherogenic lipid profile than controls at baseline, which would be ameliorated with metreleptin treatment. Objective To characterize the lipoprotein profile in patients with lipodystrophy compared with controls and to evaluate effects of metreleptin treatment. Design, Setting, Patients, and Intervention Patients with lipodystrophy (N = 17) were studied before and after metreleptin for 2 weeks and 6 months and compared with 51 insulin-sensitive sex-matched controls. Main Outcome Measures Lipoprotein profiles were measured by NMR with the LP4 deconvolution algorithm, which reports triglyceride-rich lipoprotein particles (TRLPs), high-density lipoprotein particles (HDLPs), and low-density lipoprotein particles (LDLPs). Results Patients with lipodystrophy had elevated large TRLPs and smaller HDLPs and LDLPs compared with controls. Five patients with lipodystrophy had chylomicrons, compared with zero controls. Metreleptin decreased the size and concentration of TRLPs, eliminated chylomicrons in all but one patient, decreased LDLPs, and increased LDLP size. Metreleptin treatment did not have major effects on HDLPs. Conclusions Patients with lipodystrophy had an atherogenic lipoprotein profile at baseline consistent with elevated CVD risk, which improved after metreleptin treatment. The presence of fasting chylomicrons in a subset of patients with lipodystrophy suggests saturation of chylomicron clearance by lipoprotein lipase.

scholarly journals Decreased adiponectin levels in familial combined hyperlipidemia patients contribute to the atherogenic lipid profile

2005 ◽  
Vol 46 (11) ◽  
pp. 2398-2404 ◽  
Author(s):  
Gerly M. van der Vleuten ◽  
Lambertus J. H. van Tits ◽  
Martin den Heijer ◽  
Heidi Lemmers ◽  
Anton F. H. Stalenhoef ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Familial Combined Hyperlipidemia ◽  
Atherogenic Lipid Profile ◽  
Atherogenic Lipid

PM367 Stable Angina Pectoris And Diabetes Mellitus Of Type 2: The Role Of The Atherogenic Lipid Profile And Inflammatory Markers

Global Heart ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e136
Author(s):  
Ludmila Gapon ◽  
Tatiana Petelina ◽  
Natalia Musikhina ◽  
Natalia Dementjeva ◽  
Vadim Kuznetsov
Keyword(s):  
Diabetes Mellitus ◽  
Angina Pectoris ◽  
Lipid Profile ◽  
Stable Angina ◽  
Inflammatory Markers ◽  
Stable Angina Pectoris ◽  
Atherogenic Lipid Profile ◽  
Atherogenic Lipid

Alterationsinarterial pressureinpatients with Type1diabetes are associated with long-term poor metabolic control andamore atherogenic lipid profile

2010 ◽  
Vol 34 (2) ◽  
pp. e24-e29 ◽  
Author(s):  
F. J. Vílchez-López ◽  
F. Carral-Sanlaureano ◽  
C. Coserria-Sánchez ◽  
A. Nieto ◽  
S. Jiménez ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Metabolic Control ◽  
Poor Metabolic Control ◽  
Atherogenic Lipid Profile ◽  
Atherogenic Lipid

scholarly journals Low-Grade Inflammation, Thrombogenicity, and Atherogenic Lipid Profile in Cigarette Smokers

2006 ◽  
Vol 70 (1) ◽  
pp. 8-13 ◽  
Author(s):  
Hirofumi Yasue ◽  
Nobutaka Hirai ◽  
Yuji Mizuno ◽  
Eisaku Harada ◽  
Teruhiko Itoh ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Low Grade ◽  
Cigarette Smokers ◽  
Atherogenic Lipid Profile ◽  
Low Grade Inflammation ◽  
Atherogenic Lipid

scholarly journals Deficient serum 25-hydroxyvitamin D is associated with an atherogenic lipid profile: The Very Large Database of Lipids (VLDL-3) study

2016 ◽  
Vol 10 (1) ◽  
pp. 72-81.e1 ◽  
Author(s):  
Joshua R. Lupton ◽  
Kamil F. Faridi ◽  
Seth S. Martin ◽  
Sristi Sharma ◽  
Krishnaji Kulkarni ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Large Database ◽  
Hydroxyvitamin D ◽  
Atherogenic Lipid Profile ◽  
25 Hydroxyvitamin D ◽  
Very Large Database ◽  
Atherogenic Lipid

Effect of an Oat Bran Enriched Diet on the Atherogenic Lipid Profile in Patients with an Increased Coronary Heart Disease Risk

2003 ◽  
Vol 47 (6) ◽  
pp. 306-311 ◽  
Author(s):  
Aloys Berg ◽  
Daniel König ◽  
Peter Deibert ◽  
Dominik Grathwohl ◽  
Andreas Berg ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Lipid Profile ◽  
Coronary Heart Disease Risk ◽  
Disease Risk ◽  
Atherogenic Lipid Profile ◽  
Oat Bran ◽  
Heart Disease Risk ◽  
Atherogenic Lipid

scholarly journals Skin tags and the atherogenic lipid profile

2002 ◽  
Vol 55 (8) ◽  
pp. 639-a-639 ◽  
Author(s):  
P Twomey
Keyword(s):  
Lipid Profile ◽  
Atherogenic Lipid Profile ◽  
Skin Tags ◽  
Atherogenic Lipid
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