In vivo pharmacokinetics of calreticulin S-domain, an inhibitor of the classical complement pathway

2002 ◽  
Vol 2 (4) ◽  
pp. 415-422 ◽  
Author(s):  
Nicholas J. Lynch ◽  
Heiko Schneider ◽  
Robert B. Sim ◽  
Ulrich Bickel ◽  
Wilhelm J. Schwaeble
Keyword(s):  
Complement Pathway ◽  
Classical Complement Pathway ◽  
In Vivo Pharmacokinetics ◽  
Classical Complement

Identification and characterization of classical complement pathway inhibitors and their application to in vivo and ex vivo disease models

2013 ◽  
Vol 56 (3) ◽  
pp. 290
Author(s):  
G. Parry ◽  
S. Panicker ◽  
T. Byun ◽  
C. Ramos ◽  
S. Tom ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Disease Models ◽  
Complement Pathway ◽  
Classical Complement Pathway ◽  
Identification And Characterization ◽  
Classical Complement

scholarly journals Continual Low-Level Activation of the Classical Complement Pathway

2001 ◽  
Vol 194 (6) ◽  
pp. 747-756 ◽  
Author(s):  
Anthony P. Manderson ◽  
Matthew C. Pickering ◽  
Marina Botto ◽  
Mark J. Walport ◽  
Christopher R. Parish
Keyword(s):  
Complement Activation ◽  
Alternative Pathway ◽  
Blood Stasis ◽  
Classical Pathway ◽  
Complement Pathway ◽  
Complement Components ◽  
Classical Complement Pathway ◽  
Alternative Complement ◽  
Classical Complement

There is evidence that the classical complement pathway may be activated via a “C1-tickover” mechanism, analogous to the C3-tickover of the alternative pathway. We have quantitated and characterized this pathway of complement activation. Analysis of freshly collected mouse and human plasma revealed that spontaneous C3 activation rapidly occurred with the generation of C3 fragments in the plasma. By the use of complement- and Ig-deficient mice it was found that C1q, C4, C2, and plasma Ig were all required for this spontaneous C3 activation, with the alternative complement pathway further amplifying C3 fragment generation. Study of plasma from a human with C1q deficiency before and after therapeutic C1q infusion confirmed the existence of a similar pathway for complement activation in humans. Elevated levels of plasma C3 were detected in mice deficient in complement components required for activation of either the classical or alternative complement pathways, supporting the hypothesis that there is continuous complement activation and C3 consumption through both these pathways in vivo. Blood stasis was found to stimulate C3 activation by classical pathway tick-over. This antigen-independent mechanism for classical pathway activation may augment activation of the complement system at sites of inflammation and infarction.

scholarly journals Consumption of C4b-binding protein (C4BP) during in vivo activation of the classical complement pathway

1999 ◽  
Vol 116 (2) ◽  
pp. 220-224 ◽  
Author(s):  
L. BERGAMASCHINI ◽  
A. MIEDICO ◽  
M. CICARDI ◽  
R. COPPOLA ◽  
E. N. FAIONI ◽  
...  
Keyword(s):  
Binding Protein ◽  
Complement Pathway ◽  
Classical Complement Pathway ◽  
Classical Complement

scholarly journals Carbamylation of immunoglobulin abrogates activation of the classical complement pathway

2014 ◽  
Vol 44 (11) ◽  
pp. 3403-3412 ◽  
Author(s):  
Catalin Koro ◽  
Ewa Bielecka ◽  
Anders Dahl‐Knudsen ◽  
Jan J. Enghild ◽  
Carsten Scavenius ◽  
...  
Keyword(s):  
Complement Pathway ◽  
Classical Complement Pathway ◽  
Classical Complement

scholarly journals Aggregation State-Dependent Activation of the Classical Complement Pathway by the Amyloid β Peptide

2002 ◽  
Vol 69 (1) ◽  
pp. 388-398 ◽  
Author(s):  
Scott Webster ◽  
Bonnie Bradt ◽  
Joseph Rogers ◽  
Neil Cooper
Keyword(s):  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Complement Pathway ◽  
Aggregation State ◽  
Classical Complement Pathway ◽  
State Dependent ◽  
Classical Complement

scholarly journals C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Rhona McGonigal ◽  
Madeleine E. Cunningham ◽  
Denggao Yao ◽  
Jennifer A. Barrie ◽  
Sethu Sankaranarayanan ◽  
...  
Keyword(s):  
Mouse Model ◽  
Axonal Neuropathy ◽  
Complement Pathway ◽  
Acute Motor Axonal Neuropathy ◽  
Classical Complement Pathway ◽  
Targeted Inhibition ◽  
Classical Complement

Liposome-induced activation of the classical complement pathway does not require immunoglobulin

1994 ◽  
Vol 1192 (1) ◽  
pp. 35-44 ◽  
Author(s):  
Jihan Marjan ◽  
Zongcen Xie ◽  
Dana V. Devine
Keyword(s):  
Complement Pathway ◽  
Classical Complement Pathway ◽  
Classical Complement
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