scholarly journals P068 Presence of Candida dubliniensis in the cystic fibrosis respiratory tract was associated with a significant decline in lung function – results from a 16-year retrospective study

2018 ◽  
Vol 17 ◽  
pp. S78
Author(s):  
M. Al Shakirchi ◽  
L. Klingspor ◽  
P. Bergman ◽  
I. de Monestrol ◽  
L. Hjelte
Keyword(s):  
Cystic Fibrosis ◽  
Retrospective Study ◽  
Lung Function ◽  
Respiratory Tract ◽  
Significant Decline ◽  
Candida Dubliniensis

Phenazine Content in the Cystic Fibrosis Respiratory Tract Negatively Correlates with Lung Function and Microbial Complexity

2012 ◽  
Vol 47 (6) ◽  
pp. 738-745 ◽  
Author(s):  
Ryan C. Hunter ◽  
Vanja Klepac-Ceraj ◽  
Magen M. Lorenzi ◽  
Hannah Grotzinger ◽  
Thomas R. Martin ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Respiratory Tract

Effects of Viral Lower Respiratory Tract Infection on Lung Function in Infants With Cystic Fibrosis

PEDIATRICS ◽  
1999 ◽  
Vol 103 (3) ◽  
pp. 619-626 ◽  
Author(s):  
P. W. Hiatt ◽  
S. C. Grace ◽  
C. A. Kozinetz ◽  
S. H. Raboudi ◽  
D. G. Treece ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Lower Respiratory Tract Infection ◽  
Lower Respiratory Tract

scholarly journals High prevalence of Candida dubliniensis in lower respiratory tract secretions from cystic fibrosis patients may be related to increased adherence properties

2014 ◽  
Vol 24 ◽  
pp. 14-19 ◽  
Author(s):  
Atqah Abdul Wahab ◽  
Saad J. Taj-Aldeen ◽  
Anna Kolecka ◽  
Mei ElGindi ◽  
Jonathan S. Finkel ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Respiratory Tract ◽  
Lower Respiratory Tract ◽  
Candida Dubliniensis ◽  
High Prevalence

Chronic polypous rhinosinusitis and lung function in the profile of multi-organ pathology in children with cystic fibrosis in the Russian Federation

2021 ◽  
Vol 31 (2) ◽  
pp. 207-215
Author(s):  
D. P. Polyakov ◽  
N. A. Daykhes ◽  
A. S. Yunusov ◽  
O. V. Karneeva ◽  
A. S. Petrov ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Respiratory Tract ◽  
Chronic Rhinosinusitis ◽  
Russian Federation ◽  
Paranasal Sinuses ◽  
Respiratory Function ◽  
Organ Damage ◽  
Nonparametric Tests ◽  
The Russian Federation

Chronic rhinosinusitis (CRS), including chronic rhinosinusitis with nasal polyps (CRSwNP), is one of the manifestations of cystic fibrosis (CF). The paranasal sinuses (PNS) are considered as a reservoir of pathogenic microflora and a source of descending infection of the entire respiratory tract. Nevertheless, paranasal sinuses pathology is usually assessed in isolation from both the lower respiratory tract and the entire spectrum of multiple organ damage in CF.Aim. To determine the prevalence of CRSwNP and its correlation with other characteristics of CF in children in Russia.Methods. The study included data of 2216 children from 0 to 18 years old from 81 regions of the Russian Federation from the Registry of patients with cystic fibrosis in the Russian Federation for 2018. Children with an established diagnosis of CRSwNP (n = 599) were compared to those without this condition (n = 1 617). The prevalence was assessed in the subgroups by age, sex, respiratory function, nutritional status, microbiological status, complications, the need for various therapies, and the average duration of inpatient treatment during the year. The statistical analysis included parametric and nonparametric tests.Results. According to the Registry, the average prevalence of CRSwNP among children with CF was 27.03% and tended to increase with age. Children with CRSwNP had statistically significant higher incidence of homozygous F508del mutation, more common intermittent and chronic infection with P. aeruginosa, S. aureus (MSSA and MRSA), cystic fibrosis-associated diabetes mellitus with daily use of insulin, liver damage (as with or without cirrhosis), osteoporosis, a more frequent need for systemic antibacterial and inhalation (except for bronchodilators) therapy, as well as a relatively high need for hospital stay. Unexpectedly, the respiratory function indicators (FEV1, %, FVC, %) and body mass index turned out to be higher in the group of patients with nasal polyposis. A likely explanation is that the study included only children, and the lung function was not analyzed in the children and adolescents.Conclusion. The results suggest that CRSwNP is a predictor of adverse course of CF and requires attention from CF specialists and otorhinolaryngologists, as well as interdisciplinary collaborations.

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