Changes in lung function measured by spirometry and the forced oscillation technique in cystic fibrosis patients undergoing treatment for respiratory tract exacerbation

2006 ◽  
Vol 41 (4) ◽  
pp. 345-349 ◽  
Author(s):  
Clement L. Ren ◽  
Justin L. Brucker ◽  
Amy K. Rovitelli ◽  
Kimberly A. Bordeaux
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Respiratory Tract ◽  
Forced Oscillation ◽  
Forced Oscillation Technique

scholarly journals Forced Oscillation Technique for Monitoring the Respiratory Status of Children with Cystic Fibrosis: A Systematic Review

Children ◽  
2021 ◽  
Vol 8 (10) ◽  
pp. 857
Author(s):  
Ioanna Loukou ◽  
Maria Moustaki ◽  
Agni Deligianni ◽  
Olympia Sardeli ◽  
Konstantinos Douros
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Children And Adolescents ◽  
Forced Oscillation ◽  
Clinical Symptoms ◽  
Current Evidence ◽  
Forced Oscillation Technique ◽  
Gold Standard Method ◽  
Respiratory Status ◽  
Alternative Modality

Spirometry is considered the gold standard method for monitoring lung function of patients with cystic fibrosis (CF) but it requires patients’ cooperation and therefore it is not useful for the majority of preschool-aged children. Oscillometry is an alternative modality for lung function monitoring that requires minimal cooperation and can be applied in children as young as 3 years of age. Furthermore, it generates lesser aerosol compared to spirometry, an issue that is of considerable importance in the COVID-19 era. The aim of this review was to present the existing clinical data regarding the application of oscillometry in children and adolescents with CF. The method seems to have acceptable feasibility and repeatability. However, there is conflicting data regarding the correlation of oscillometry values with the clinical symptoms of CF patients either in clinically stable or in exacerbation periods. Furthermore, it is not clear to what extent oscillometry measurements correlate with the spirometry indices. Based on current evidence, spirometry cannot be substituted by oscillometry in the monitoring of the respiratory status of children and adolescents with CF.

Phenazine Content in the Cystic Fibrosis Respiratory Tract Negatively Correlates with Lung Function and Microbial Complexity

2012 ◽  
Vol 47 (6) ◽  
pp. 738-745 ◽  
Author(s):  
Ryan C. Hunter ◽  
Vanja Klepac-Ceraj ◽  
Magen M. Lorenzi ◽  
Hannah Grotzinger ◽  
Thomas R. Martin ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Respiratory Tract

No Paradoxical Bronchodilator Response with Forced Oscillation Technique in Children With Cystic Fibrosis

CHEST Journal ◽  
1998 ◽  
Vol 113 (1) ◽  
pp. 55-59 ◽  
Author(s):  
Johan Hellinckx ◽  
Kris De Boeck ◽  
Maurits Demedts
Keyword(s):  
Cystic Fibrosis ◽  
Forced Oscillation ◽  
Forced Oscillation Technique ◽  
Bronchodilator Response

scholarly journals Impact of lung disease on respiratory impedance in young children with cystic fibrosis

2015 ◽  
Vol 46 (6) ◽  
pp. 1672-1679 ◽  
Author(s):  
Kathryn A. Ramsey ◽  
Sarath C. Ranganathan ◽  
Catherine L. Gangell ◽  
Lidija Turkovic ◽  
Judy Park ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Preschool Children ◽  
Lung Disease ◽  
Forced Oscillation ◽  
Forced Oscillation Technique ◽  
Respiratory Resistance ◽  
Lung Abnormalities ◽  
Respiratory Inflammation ◽  
Function Testing ◽  
Tomography Scan

This study aimed to evaluate the ability of the forced oscillation technique (FOT) to detect underlying lung disease in preschool children with cystic fibrosis (CF) diagnosed following newborn screening.184 children (aged 3–6 years) with CF underwent lung function testing on 422 occasions using the FOT to assess respiratory resistance and reactance at the time of their annual bronchoalveolar lavage collection and chest computed tomography scan. We examined associations between FOT outcomes and the presence and progression of respiratory inflammation, infection and structural lung disease.Children with CF who had pronounced respiratory disease, including free neutrophil elastase activity, infection with pro-inflammatory pathogens and structural lung abnormalities had similar FOT outcomes to those children without detectable lung disease. In addition, the progression of lung disease over 1 year was not associated with worsening FOT outcomes.We conclude that the forced oscillation technique is relatively insensitive to detect underlying lung disease in preschool children with CF. However, FOT may still be of value in improving our understanding of the physiological changes associated with early CF lung disease.

Effects of Viral Lower Respiratory Tract Infection on Lung Function in Infants With Cystic Fibrosis

PEDIATRICS ◽  
1999 ◽  
Vol 103 (3) ◽  
pp. 619-626 ◽  
Author(s):  
P. W. Hiatt ◽  
S. C. Grace ◽  
C. A. Kozinetz ◽  
S. H. Raboudi ◽  
D. G. Treece ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Lower Respiratory Tract Infection ◽  
Lower Respiratory Tract

scholarly journals The Role of Multidetector Computed Tomography and the Forced Oscillation Technique in Assessing Lung Damage in Adults With Cystic Fibrosis

2017 ◽  
Vol 63 (4) ◽  
pp. 430-440 ◽  
Author(s):  
Letícia S Lacerda ◽  
Agnaldo J Lopes ◽  
Alysson R S Carvalho ◽  
Alan R M Guimarães ◽  
Mônica C Firmida ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Cystic Fibrosis ◽  
Multidetector Computed Tomography ◽  
Forced Oscillation ◽  
Lung Damage ◽  
Forced Oscillation Technique

scholarly journals Measuring lung function in asthmatic children: A spirometry and forced oscillation technique (FOT) comparison

2016 ◽  
Author(s):  
Giovanna Cilluffo ◽  
Salvatore Fasola ◽  
Velia Malizia ◽  
Giuliana Ferrante ◽  
Laura Montalbano ◽  
...  
Keyword(s):  
Lung Function ◽  
Forced Oscillation ◽  
Forced Oscillation Technique ◽  
Asthmatic Children

Chronic polypous rhinosinusitis and lung function in the profile of multi-organ pathology in children with cystic fibrosis in the Russian Federation

2021 ◽  
Vol 31 (2) ◽  
pp. 207-215
Author(s):  
D. P. Polyakov ◽  
N. A. Daykhes ◽  
A. S. Yunusov ◽  
O. V. Karneeva ◽  
A. S. Petrov ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Respiratory Tract ◽  
Chronic Rhinosinusitis ◽  
Russian Federation ◽  
Paranasal Sinuses ◽  
Respiratory Function ◽  
Organ Damage ◽  
Nonparametric Tests ◽  
The Russian Federation

Chronic rhinosinusitis (CRS), including chronic rhinosinusitis with nasal polyps (CRSwNP), is one of the manifestations of cystic fibrosis (CF). The paranasal sinuses (PNS) are considered as a reservoir of pathogenic microflora and a source of descending infection of the entire respiratory tract. Nevertheless, paranasal sinuses pathology is usually assessed in isolation from both the lower respiratory tract and the entire spectrum of multiple organ damage in CF.Aim. To determine the prevalence of CRSwNP and its correlation with other characteristics of CF in children in Russia.Methods. The study included data of 2216 children from 0 to 18 years old from 81 regions of the Russian Federation from the Registry of patients with cystic fibrosis in the Russian Federation for 2018. Children with an established diagnosis of CRSwNP (n = 599) were compared to those without this condition (n = 1 617). The prevalence was assessed in the subgroups by age, sex, respiratory function, nutritional status, microbiological status, complications, the need for various therapies, and the average duration of inpatient treatment during the year. The statistical analysis included parametric and nonparametric tests.Results. According to the Registry, the average prevalence of CRSwNP among children with CF was 27.03% and tended to increase with age. Children with CRSwNP had statistically significant higher incidence of homozygous F508del mutation, more common intermittent and chronic infection with P. aeruginosa, S. aureus (MSSA and MRSA), cystic fibrosis-associated diabetes mellitus with daily use of insulin, liver damage (as with or without cirrhosis), osteoporosis, a more frequent need for systemic antibacterial and inhalation (except for bronchodilators) therapy, as well as a relatively high need for hospital stay. Unexpectedly, the respiratory function indicators (FEV1, %, FVC, %) and body mass index turned out to be higher in the group of patients with nasal polyposis. A likely explanation is that the study included only children, and the lung function was not analyzed in the children and adolescents.Conclusion. The results suggest that CRSwNP is a predictor of adverse course of CF and requires attention from CF specialists and otorhinolaryngologists, as well as interdisciplinary collaborations.

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