Retraction: Phenazine Content in the Cystic Fibrosis Respiratory Tract Negatively Correlates with Lung Function and Microbial Complexity

2019 ◽  
Vol 60 (1) ◽  
pp. 134-134
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Respiratory Tract

Phenazine Content in the Cystic Fibrosis Respiratory Tract Negatively Correlates with Lung Function and Microbial Complexity

2012 ◽  
Vol 47 (6) ◽  
pp. 738-745 ◽  
Author(s):  
Ryan C. Hunter ◽  
Vanja Klepac-Ceraj ◽  
Magen M. Lorenzi ◽  
Hannah Grotzinger ◽  
Thomas R. Martin ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Respiratory Tract

Effects of Viral Lower Respiratory Tract Infection on Lung Function in Infants With Cystic Fibrosis

PEDIATRICS ◽  
1999 ◽  
Vol 103 (3) ◽  
pp. 619-626 ◽  
Author(s):  
P. W. Hiatt ◽  
S. C. Grace ◽  
C. A. Kozinetz ◽  
S. H. Raboudi ◽  
D. G. Treece ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Lower Respiratory Tract Infection ◽  
Lower Respiratory Tract

Chronic polypous rhinosinusitis and lung function in the profile of multi-organ pathology in children with cystic fibrosis in the Russian Federation

2021 ◽  
Vol 31 (2) ◽  
pp. 207-215
Author(s):  
D. P. Polyakov ◽  
N. A. Daykhes ◽  
A. S. Yunusov ◽  
O. V. Karneeva ◽  
A. S. Petrov ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Respiratory Tract ◽  
Chronic Rhinosinusitis ◽  
Russian Federation ◽  
Paranasal Sinuses ◽  
Respiratory Function ◽  
Organ Damage ◽  
Nonparametric Tests ◽  
The Russian Federation

Chronic rhinosinusitis (CRS), including chronic rhinosinusitis with nasal polyps (CRSwNP), is one of the manifestations of cystic fibrosis (CF). The paranasal sinuses (PNS) are considered as a reservoir of pathogenic microflora and a source of descending infection of the entire respiratory tract. Nevertheless, paranasal sinuses pathology is usually assessed in isolation from both the lower respiratory tract and the entire spectrum of multiple organ damage in CF.Aim. To determine the prevalence of CRSwNP and its correlation with other characteristics of CF in children in Russia.Methods. The study included data of 2216 children from 0 to 18 years old from 81 regions of the Russian Federation from the Registry of patients with cystic fibrosis in the Russian Federation for 2018. Children with an established diagnosis of CRSwNP (n = 599) were compared to those without this condition (n = 1 617). The prevalence was assessed in the subgroups by age, sex, respiratory function, nutritional status, microbiological status, complications, the need for various therapies, and the average duration of inpatient treatment during the year. The statistical analysis included parametric and nonparametric tests.Results. According to the Registry, the average prevalence of CRSwNP among children with CF was 27.03% and tended to increase with age. Children with CRSwNP had statistically significant higher incidence of homozygous F508del mutation, more common intermittent and chronic infection with P. aeruginosa, S. aureus (MSSA and MRSA), cystic fibrosis-associated diabetes mellitus with daily use of insulin, liver damage (as with or without cirrhosis), osteoporosis, a more frequent need for systemic antibacterial and inhalation (except for bronchodilators) therapy, as well as a relatively high need for hospital stay. Unexpectedly, the respiratory function indicators (FEV1, %, FVC, %) and body mass index turned out to be higher in the group of patients with nasal polyposis. A likely explanation is that the study included only children, and the lung function was not analyzed in the children and adolescents.Conclusion. The results suggest that CRSwNP is a predictor of adverse course of CF and requires attention from CF specialists and otorhinolaryngologists, as well as interdisciplinary collaborations.

scholarly journals Detection and monitoring of lung inflammation in cystic fibrosis during respiratory tract exacerbation using diffusion-weighted magnetic resonance imaging

2017 ◽  
Vol 50 (1) ◽  
pp. 1601437 ◽  
Author(s):  
Pierluigi Ciet ◽  
Silvia Bertolo ◽  
Mirco Ros ◽  
Eleni Rosalina Andrinopoulou ◽  
Valentina Tavano ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cystic Fibrosis ◽  
Magnetic Resonance ◽  
Lung Function ◽  
Respiratory Tract ◽  
Antibiotic Treatment ◽  
Clinical Status ◽  
Control Group ◽  
Resonance Imaging ◽  
Weighted Magnetic Resonance Imaging

The aim was to investigate whether diffusion-weighted magnetic resonance imaging (DWI) detects and monitors inflammatory and lung function changes during respiratory tract exacerbations (RTE) treatment in patients with cystic fibrosis (CF).29 patients with RTE underwent DWI pre- and post-antibiotic treatment. A control group of 27 stable patients, matched for age and sex, underwent DWI with the same time gap as those undergoing RTE treatment. Clinical status and lung function were assessed at each DWI time point. The CF-MRI scoring system was used to assess structural lung changes in both CF groups.Significant reduction in the DWI score over the course of antibiotic treatment (p<0.0001) was observed in patients with RTE, but not in the control group. DWI score had a strong inverse correlation with clinical status (r=−0.504, p<0.0001) and lung function (r=−0.635, p<0.0001) in patients with RTE. Interestingly, there were persistent significant differences in the CF-MRI score between the RTE and control group at both baseline and follow-up (p<0.001), while the differences in DWI score were only observed at baseline (p<0.001).DWI is a promising imaging method for noninvasive detection of pulmonary inflammation during RTE, and may be used to monitor treatment efficacy of anti-inflammatory treatment.

Improved lung function using a therapeutic educational multidisciplinary program in a pediatric cystic fibrosis clinic

2013 ◽  
Vol 5 (1) ◽  
pp. 131-136
Author(s):  
Yann Kernen ◽  
Claudine Durussel ◽  
Pierluigi Ballabeni ◽  
Gaudenz Martin Hafen
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Multidisciplinary Program

Respiratory tract microbiocenosis in children with cystic fibrosis in Kharkiv region

2016 ◽  
Vol 78 (6) ◽  
pp. 24-26
Author(s):  
V.A. Klymenko ◽  
◽  
Y.A. Yanovskaya ◽  
Y.V. Pasichnik ◽  
◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Respiratory Tract
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