Chapter 6.4 Microdialysis as a method to study blood-brain barrier transport mechanisms

2006 ◽  
pp. 545-572 ◽  
Author(s):  
Elizabeth C.M. de Lange
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Transport Mechanisms ◽  
Blood Brain

scholarly journals Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain

2017 ◽  
Vol 117 ◽  
pp. 182-194 ◽  
Author(s):  
Kerstin Römermann ◽  
Maren Fedrowitz ◽  
Philip Hampel ◽  
Edith Kaczmarek ◽  
Kathrin Töllner ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Therapeutic Potential ◽  
Brain Barrier ◽  
Mammalian Brain ◽  
Transport Mechanisms ◽  
Blood Brain ◽  
Multiple Blood

scholarly journals Design and Development of Nanomaterial-Based Drug Carriers to Overcome the Blood–Brain Barrier by Using Different Transport Mechanisms

2021 ◽  
Vol 22 (18) ◽  
pp. 10118
Author(s):  
Jisu Song ◽  
Chao Lu ◽  
Jerzy Leszek ◽  
Jin Zhang
Keyword(s):  
Drug Delivery ◽  
Blood Brain Barrier ◽  
Drug Carriers ◽  
Brain Barrier ◽  
Transport Mechanisms ◽  
Cns Diseases ◽  
Routes Of Administration ◽  
Neurotropic Viruses ◽  
Blood Brain ◽  
Novel Drug

Central nervous system (CNS) diseases are the leading causes of death and disabilities in the world. It is quite challenging to treat CNS diseases efficiently because of the blood–brain barrier (BBB). It is a physical barrier with tight junction proteins and high selectivity to limit the substance transportation between the blood and neural tissues. Thus, it is important to understand BBB transport mechanisms for developing novel drug carriers to overcome the BBB. This paper introduces the structure of the BBB and its physiological transport mechanisms. Meanwhile, different strategies for crossing the BBB by using nanomaterial-based drug carriers are reviewed, including carrier-mediated, adsorptive-mediated, and receptor-mediated transcytosis. Since the viral-induced CNS diseases are associated with BBB breakdown, various neurotropic viruses and their mechanisms on BBB disruption are reviewed and discussed, which are considered as an alternative solution to overcome the BBB. Therefore, most recent studies on virus-mimicking nanocarriers for drug delivery to cross the BBB are also reviewed and discussed. On the other hand, the routes of administration of drug-loaded nanocarriers to the CNS have been reviewed. In sum, this paper reviews and discusses various strategies and routes of nano-formulated drug delivery systems across the BBB to the brain, which will contribute to the advanced diagnosis and treatment of CNS diseases.

Transport Mechanisms of Squalenoyl-Adenosine Nanoparticles Across the Blood–Brain Barrier

2015 ◽  
Vol 27 (10) ◽  
pp. 3636-3647 ◽  
Author(s):  
Alice Gaudin ◽  
Oya Tagit ◽  
Dunja Sobot ◽  
Sinda Lepetre-Mouelhi ◽  
Julie Mougin ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Transport Mechanisms ◽  
Blood Brain
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