MSH2 MUTATIONS AND BLADDER CANCER RISK: FAMILY MEMBERS OF HEREDITARY NONPOLYPOSIS COLORECTAL CANCER (HNPCC) PATIENTS WITH MSH2 MUTATIONS ARE AT INCREASED RISK NOT ONLY FOR UPPER URINARY TRACT TRANSITIONAL CELL CARCINOMA (TCC) BUT ALSO BLADDER CANCER

2008 ◽  
Vol 7 (3) ◽  
pp. 290 ◽  
Author(s):  
S. Skeldon ◽  
K. Semotiuk ◽  
S. Gallinger ◽  
N. Fleshner ◽  
M. Cotterchio ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Bladder Cancer ◽  
Urinary Tract ◽  
Cancer Risk ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Transitional Cell ◽  
Upper Urinary Tract ◽  
Bladder Cancer Risk ◽  
Increased Risk ◽  
Hereditary Nonpolyposis

Hereditary Nonpolyposis Colorectal Cancer Syndrome in a Patient With Urothelial Carcinoma of the Upper Urothelial Tract

2003 ◽  
Vol 127 (2) ◽  
pp. e60-e63
Author(s):  
Arndt Hartmann ◽  
John C. Cheville ◽  
Wolfgang Dietmaier ◽  
Ferdinand Hofstädter ◽  
Lawrence J. Burgart ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Upper Urinary Tract ◽  
Cancer Syndrome ◽  
Tract Cancer ◽  
Hereditary Nonpolyposis ◽  
History Of ◽  
History Of Cancer

Abstract Urothelial carcinoma of the upper urinary tract is relatively uncommon but may develop as a manifestation of the hereditary nonpolyposis colorectal cancer syndrome (HNPCC), which is characterized by mutations in a number of DNA mismatch repair genes and detectable as microsatellite instability or loss of the respective protein by immunostaining. No well-established screening test is available for urothelial carcinomas of the upper urinary tract, and little is known of the clinical impact of screening for HNPCC in patients with upper urinary tract cancer. We describe herein a patient with a urothelial carcinoma of the ureter and a strongly positive history of cancer, who was subsequently found to have HNPCC. Our findings reinforce the importance of obtaining a comprehensive history of cancer in patients with urothelial carcinoma of the renal pelvis and ureter. Subsequent identification of individuals with HNPCC enables the patient and at-risk relatives to benefit from targeted surveillance and management programs.

Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis

1996 ◽  
Vol 110 (4) ◽  
pp. 1020-1027 ◽  
Author(s):  
HF Vasen ◽  
JT Wijnen ◽  
FH Menko ◽  
JH Kleibeuker ◽  
BG Taal ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Mutation Analysis ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Hereditary Nonpolyposis

Cancer risk in hereditary nonpolyposis colorectal cancer due to MSH6 mutations: impact on counseling and surveillance

2004 ◽  
Vol 127 (1) ◽  
pp. 17-25 ◽  
Author(s):  
Yvonne M.C. Hendriks ◽  
Anja Wagner ◽  
Hans Morreau ◽  
Fred Menko ◽  
Astrid Stormorken ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Hereditary Nonpolyposis

Upper urinary tract cancer: Prognostic factors for bladder tumours development and systemic relapse

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 14560-14560
Author(s):  
F. Merlin ◽  
M. Riolfi ◽  
T. Sava ◽  
F. Consoli ◽  
C. Griso ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Prognostic Factors ◽  
Urinary Tract ◽  
Vascular Invasion ◽  
Superficial Bladder Cancer ◽  
Transitional Cell ◽  
Upper Urinary Tract ◽  
Upper Tract ◽  
Well Differentiated ◽  
Systemic Relapse

14560 Background: Transitional cell carcinomas (TCC) of the renal pelvis and ureter are relatively uncommon. An important characteristic of TCC is multifocality throughout the all urinary tract simultaneously and/or subsequently. To clarify the association between UTTCC and bladder tumors, we retrospectively analysed 86 patients with UTTCC in order to evaluate prognostic factors for recurrence and to identify risk factors for development of bladder cancers. Methods: All 86 upper tract transitional cell carcinoma patients (pts) were treated surgically between January 1988 and July 2005. Median age was 69 years (range: 34–91). We observed a male predominance (71%) and 78% of patients were heavy smokers. Forty-five (52.3%) patients had a diagnosis of bladder transitional carcinoma. The median age of this group of patients was 70 range 40–87). In fifteen cases (17%), bladder tumour occurred first than upper tract neoplasia; in 14 patients bladder and upper tract tumours were synchronous. Results: Median survival was 97 months; 49 (57%) patients are alive and 43 are disease-free. Grading, stage T, lympho-vascular invasion and squamous differentiation were significant prognostic factors for systemic relapse (p < 0.05). Twenty-eight pts (32.5%) developed subsequent transitional bladder cancer after a median time of 12 months; multifocality of primitive tumours was significant predictive factor. Invasive UTTCC were less likely associated with bladder cancer. We observed that superficial bladder cancer developed more frequently in pts with well differentiated (G1–2) primitive cancer (90% of cases), without lympho-vascular invasion and with history of heavy smoke exposition. Conclusions: In our study, T, N and G confirmed to be the most important prognostic factors for systemic relapse. Lympho-vascular invasion highly predicts metastasis. Our analysis highlights that upper urinary tract cancers seem to have different history and different pattern of association with bladder tumours, according to specific prognostic factors. The development of recurrent superficial bladder cancer is more frequently associated with small well differentiated multifocal upper tract tumours.Therefore follow-up should be oriented according to these characteristics. No significant financial relationships to disclose.

URINARY TRACT CANCER AND HEREDITARY NONPOLYPOSIS COLORECTAL CANCER

1998 ◽  
pp. 466-470 ◽  
Author(s):  
R. H. SIJMONS ◽  
L. A. L. M. KIEMENEY ◽  
J. A. WITJES ◽  
H. F. A. VASEN
Keyword(s):  
Colorectal Cancer ◽  
Urinary Tract ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Tract Cancer ◽  
Urinary Tract Cancer ◽  
Hereditary Nonpolyposis

Cancer Risk in Hereditary Nonpolyposis Colorectal Cancer Syndrome: Later Age of Onset

2005 ◽  
Vol 129 (2) ◽  
pp. 415-421 ◽  
Author(s):  
H HAMPEL ◽  
J STEPHENS ◽  
E PUKKALA ◽  
R SANKILA ◽  
L AALTONEN ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Age Of Onset ◽  
Cancer Syndrome ◽  
Hereditary Nonpolyposis
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