Long-term follow-up in high risk non muscle invasive bladder cancer (NMIBC) “en-bloc” resection

2018 ◽  
Vol 17 (2) ◽  
pp. e1063 ◽  
Author(s):  
R. Hurle ◽  
M. Lazzeri ◽  
A. Saita ◽  
N. Buffi ◽  
G. Lughezzani ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
High Risk ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Muscle Invasive Bladder Cancer ◽  
En Bloc ◽  
Long Term Follow Up ◽  
Muscle Invasive

PD12-11 LONG-TERM FOLLOW-UP IN HIGH RISK NON MUSCLE INVASIVE BLADDER CANCER “EN-BLOC” RESECTION

2020 ◽  
Vol 203 ◽  
pp. e263
Author(s):  
Marco Paciotti* ◽  
Fasulo Vittorio ◽  
Massimo Lazzeri ◽  
Domanico Luigi ◽  
Federica Regis ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
High Risk ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Muscle Invasive Bladder Cancer ◽  
En Bloc ◽  
Long Term Follow Up ◽  
Muscle Invasive

scholarly journals Long-term Follow-up After En Bloc Transurethral Resection of Non–muscle-invasive Bladder Cancer: Results from a Single-center Experience

2021 ◽  
Vol 26 ◽  
pp. 64-71
Author(s):  
Marco Paciotti ◽  
Paolo Casale ◽  
Piergiuseppe Colombo ◽  
Vittorio Fasulo ◽  
Alberto Saita ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Transurethral Resection ◽  
Single Center ◽  
Muscle Invasive Bladder Cancer ◽  
En Bloc ◽  
Single Center Experience ◽  
Long Term Follow Up ◽  
Muscle Invasive

scholarly journals Long-term follow-up after colorectal endoscopic submucosal dissection in 182 cases

2021 ◽  
Vol 09 (02) ◽  
pp. E258-E262
Author(s):  
Christian Suchy ◽  
Moritz Berger ◽  
Ingo Steinbrück ◽  
Tsuneo Oyama ◽  
Naohisa Yahagi ◽  
...  
Keyword(s):  
Case Series ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Published Data ◽  
Low Grade ◽  
Recurrence Rates ◽  
En Bloc ◽  
Long Term Follow Up

Abstract Background and study aims We previously reported a case series of our first 182 colorectal endoscopic submucosal dissections (ESDs). In the initial series, 155 ESDs had been technically feasible, with 137 en bloc resections and 97 en bloc resections with free margins (R0). Here, we present long-term follow-up data, with particular emphasis on cases where either en bloc resection was not achieved or en bloc resection resulted in positive margins (R1). Patients and methods Between September 2012 and October 2015, we performed 182 consecutive ESD procedures in 178 patients (median size 41.0 ± 17.4 mm; localization rectum vs. proximal rectum 63 vs. 119). Data on follow-up were obtained from our endoscopy database and from referring physicians. Results Of the initial cohort, 11 patients underwent surgery; follow-up data were available for 141 of the remaining 171 cases (82,5 %) with a median follow-up of 2.43 years (range 0.15–6.53). Recurrent adenoma was observed in 8 patients (n = 2 after margin positive en bloc ESD; n = 6 after fragmented resection). Recurrence rates were lower after en bloc resection, irrespective of involved margins (1.8 vs. 18,2 %; P < 0.01). All recurrences were low-grade adenomas and could be managed endoscopically. Conclusions The rate of recurrence is low after en bloc ESD, in particular if a one-piece resection can be achieved. Recurrence after fragmented resection is comparable to published data on piecemeal mucosal resection.

The efficacy and safety of EN BLOC resection in non-muscle-invasive bladder cancer

2020 ◽  
Vol 8 (1) ◽  
pp. 26-39
Author(s):  
E.A. Laukhtina ◽  
◽  
A.D. Shpikina ◽  
M.S. Taratkin ◽  
D.V. Enikeev ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Bladder Wall ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Invasive Bladder Cancer ◽  
Muscle Invasive Bladder Cancer ◽  
En Bloc ◽  
Invasive Tumour ◽  
Operative Complications ◽  
Muscle Invasive

In surgical treatment of non-muscle-invasive bladder cancer (BC) the en bloc resection technique – removal of tumour in a single piece with the subjacent muscle (detrusor) – is becoming more widely used. The objective of this review was to assess the oncological efficacy (relapse incidence) and safety (of peri- and post-operative complications) of this technique for various tumour sizes. This systematic review was written in accordance with the PRISMA criteria. The relevant literature published over the past 20 years was chosen in two databases (Medline and Scopus) with the use of the search query “en bloc” and “bladder cancer”. We selected publications that assessed the efficacy and safety of en bloc resection of the bladder wall with non-muscle-invasive tumour, and also publications comparing the efficacy of en bloc резекции resection with that of transurethral resection (TUR) of the bladder. Based on analysis of 18 studies (1592 patients after en bloc resection), the following conclusions were made: the incidence of BC relapses after en bloc resection of the bladder wall (with non-muscle-invasive tumour) is significantly lower than after conventional TUR of the bladder; a practically 100-percent presence of muscle fibers is found in the histological tumour specimen; the frequency of peri- and post-operative complications in en bloc resection is significantly lower as compared with classical TUR; the choice of a power source does not influence the oncological outcomes, but laser en bloc resection is safer than electrical; extraction of tumours with sizes up to 2-3 cm is possible in one piece; tumours of larger diameters should be preliminary fragmented in the bladder cavity; comparison of tumours of various diameters did not reveal any statistical differences between the oncological outcomes of patients. The technique of en bloc resection of the bladder wall with non-muscle-invasive tumour is effective and safe for removal of smaller tumours (~ to 2 cm); as some authors point out, it is also effective in larger tumours but there are no literature evidence sufficient for such an. Key words: systematic review, en bloc resection, non-muscle-invasive bladder cancer

Therapeutic strategy involving endoscopic resection for cN0 superficial carcinoma of the esophagus.

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 1-1
Author(s):  
T. Iizuka ◽  
D. Kikuchi ◽  
S. Hoteya
Keyword(s):  
Endoscopic Resection ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Additional Treatment ◽  
En Bloc ◽  
Carcinoma Of The Esophagus ◽  
Secondary Hemorrhage ◽  
Long Term Follow Up

1 Background: With the progress in endoscopic submucosal dissection (ESD) which enables en bloc resection irrespective of the size of lesion, a therapeutic strategy has become feasible whereby ESD is undertaken first, followed by considering additional treatment based on the results of histologic exploration. In this study, we attempted to clarify the clinical results in patients who had undergone additional treatment after endoscopic resection (ER) for cN0 superficial carcinoma. Methods: Of 140 patients diagnosed as having T1a-MM-SM2 lesions of squamous cell carcinoma of the esophagus who had undergone ER between January 1998 and March 2010, 83 patients who received additional treatment after ER (surgery, 27 pts; chemoradiotherapy [CRT], 56 pts.) were the subjects of this study. The mean duration of observation was 45.1 months. Results: The en bloc resection rate was 86%. There were 5 patients (6%) who had complications associated with ER, including perforation in 2 patients, secondary hemorrhage in a patient and pneumonia in 2 patients. Complications associated with additional treatment were noted in 13 patients (15.6%), including secondary hemorrhage, recurrent laryngeal nerve paralysis and pulmonary infarction in one patient each, pneumonia in 3, grade ≥ 3 myelosuppression in 5, and syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and radiation pneumonitis in one patient each. Long-term follow-up revealed no local recurrence and no patients who experienced late toxicity due to CRT. The tumor recurred in 4 patients, the site of recurrent lesion being the mediastinum in 3 patients and the cervical lymph node in one patient, of whom 2 patients died of the primary disease. The 5-year survival rate was 88.4%. Conclusions: Endoscopic resection plus additional treatment for superficial carcinoma of the esophagus did not entail the development of any serious complications; thus, such combined treatment was safe and feasible. The long-term follow-up results were fairly gratifying, and ER with subsequent additional treatment is considered to be valid for patients with cN0 superficial carcinoma of the esophagus. No significant financial relationships to disclose.

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