Animal modelling of lumbar corpectomy and fusion and in vivo growth of spine supporting bone by titanium cage implants: An experimental study

2010 ◽  
Vol 7 (4) ◽  
pp. 329-336 ◽  
Author(s):  
Qingxian Hou ◽  
Qingsan Zhu ◽  
Yuntao Wu ◽  
Ran Li ◽  
Dan Li ◽  
...  
Author(s):  
Edmara T. P. Bergamo ◽  
Paula G. F. P de Oliveira ◽  
Ryo Jimbo ◽  
Rodrigo Neiva ◽  
Nick Tovar ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Siamak Salehi ◽  
Oliver D. Tavabie ◽  
Augusto Villanueva ◽  
Julie Watson ◽  
David Darling ◽  
...  

AbstractRegulated cell proliferation is an effector mechanism of regeneration, whilst dysregulated cell proliferation is a feature of cancer. We have previously identified microRNA (miRNA) that regulate successful and failed human liver regeneration. We hypothesized that these regulators may directly modify tumor behavior. Here we show that inhibition of miRNAs -503 and -23a, alone or in combination, enhances tumor proliferation in hepatocyte and non-hepatocyte derived cancers in vitro, driving more aggressive tumor behavior in vivo. Inhibition of miRNA-152 caused induction of DNMT1, site-specific methylation with associated changes in gene expression and in vitro and in vivo growth inhibition. Enforced changes in expression of two miRNA recapitulating changes observed in failed regeneration led to complete growth inhibition of multi-lineage cancers in vivo. Our results indicate that regulation of regeneration and tumor aggressiveness are concordant and that miRNA-based inhibitors of regeneration may constitute a novel treatment strategy for human cancers.


Author(s):  
Atsushi Kawamura ◽  
Yosuke Akiba ◽  
Masako Nagasawa ◽  
Makiko Takashima ◽  
Yoshiaki Arai ◽  
...  

2019 ◽  
Vol 33 (9) ◽  
pp. 725-729 ◽  
Author(s):  
Yasser A. Noureldin ◽  
Panagiotis Kallidonis ◽  
Panteleimon Ntasiotis ◽  
Constantinos Adamou ◽  
Evangelos Zazas ◽  
...  

2000 ◽  
Vol 33 (2) ◽  
pp. 91-99 ◽  
Author(s):  
D. S. Gembitsky ◽  
P. M. De Angelis ◽  
K. L. Reichelt ◽  
K. Elgjo
Keyword(s):  

2010 ◽  
Vol 111 (4) ◽  
pp. 899-910 ◽  
Author(s):  
Vincent Kam Wai Wong ◽  
Simon Shiu Fai Cheung ◽  
Ting Li ◽  
Zhi-Hong Jiang ◽  
Jing-Rong Wang ◽  
...  

2013 ◽  
Vol 39 (11) ◽  
pp. 2147-2157 ◽  
Author(s):  
Hai-Peng Tong ◽  
Luo-Fu Wang ◽  
Yan-Li Guo ◽  
Lang Li ◽  
Xiao-Zhou Fan ◽  
...  

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