scholarly journals Invasive Ductal Carcinoma Arising in Phyllodes Tumor With Isolated Tumor Cells in Sentinel Lymph Node

2010 ◽  
Vol 73 (11) ◽  
pp. 602-604 ◽  
Author(s):  
Ying-Ju Kuo ◽  
Donald Ming-Tak Ho ◽  
Yi-Fang Tsai ◽  
Chih-Yi Hsu
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Tumor Cells ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Phyllodes Tumor ◽  
Isolated Tumor Cells

Ductal carcinoma in situ with isolated tumor cells in the sentinel lymph node in a 17-year-old adolescent girl

Breast Cancer ◽  
2010 ◽  
Vol 20 (3) ◽  
pp. 271-274 ◽  
Author(s):  
Tomoi Sato ◽  
Ichiro Muto ◽  
Masaki Hasegawa ◽  
Takashi Aono ◽  
Takeshi Sakai ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Tumor Cells ◽  
Ductal Carcinoma In Situ ◽  
Adolescent Girl ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Isolated Tumor Cells

scholarly journals Does small volume metastatic lymph node disease affect long-term prognosis in early cervical cancer?

2019 ◽  
Vol 30 (3) ◽  
pp. 285-290 ◽  
Author(s):  
Andra Nica ◽  
Lilian T Gien ◽  
Sarah Elizabeth Ferguson ◽  
Allan Covens
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Tumor Cells ◽  
Adjuvant Treatment ◽  
Small Volume ◽  
Pelvic Lymphadenectomy ◽  
Isolated Tumor Cells ◽  
Nodal Disease ◽  
Free Survival

IntroductionAs sentinel lymph node biopsy is evolving to an accepted standard of care, clinicians are being faced with more frequent cases of small volume nodal metastatic disease. The objective of this study is to describe the management and to measure the effect on recurrence rates of nodal micrometastasis and isolated tumor cells in patients with early stage cervical cancer at two high-volume centers.MethodsWe conducted a review of prospectively collected patients with surgically treated cervical cancer who were found to have micrometastasis or isolated tumor cells on ultrastaging of the sentinel lymph node. Our practice is to follow patients for ≥5 years post-operatively either at our center or another cancer center closer to home.ResultsNineteen patients with small volume nodal disease were identified between 2006 and 2018. Median follow-up was 62 months. Ten (53%) had nodal micrometastatic disease, while nine (47%) had isolated tumor cells detected in the sentinel lymph node. Seven patients (37%) underwent completion pelvic lymphadenectomy and four of them also had para-aortic lymphadenectomy; there were no positive non-sentinel lymph nodes. The majority (74%) received adjuvant treatment, mostly driven by tumor factors. We observed two recurrences. Recurrence-free survival was comparable with historical cohorts of node negative patients, and adjuvant treatment did not seem to impact the recurrence rate (p=0.5).ConclusionGiven the uncertainties around the prognostic significance of small volume nodal disease in cervical cancer, a large proportion of patients receive adjuvant treatment. We found no positive non-sentinel lymph nodes, suggesting that pelvic lymphadenectomy or para-aortic lymphadenectomy may not be of benefit in patients diagnosed with small volume nodal metastases. Recurrence-free survival in this group did not seem to be affected. However, given the small numbers of patients and lack of level 1 evidence, decisions should be individualized in accordance with patient preferences and tumor factors.

Invasive ductal carcinoma of the mammary like glands of vulva-with sentinel lymph node identification

2013 ◽  
Vol 35 (4/Supplement) ◽  
pp. 1-5
Author(s):  
İlknur Çetinaslan Türkmen ◽  
Nuray Başsüllü ◽  
Cem Murat Baykal ◽  
İlkkan Dünder ◽  
Gülen Bülbül Doğusoy
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Sentinel Lymph Node Identification

scholarly journals Factors influencing the adoption of the sentinel lymph node technique for endometrial cancer staging: an international survey of gynecologic oncologists

2019 ◽  
Vol 29 (1) ◽  
pp. 60-67 ◽  
Author(s):  
Jvan Casarin ◽  
Francesco Multinu ◽  
Nadeem Abu-Rustum ◽  
David Cibula ◽  
William A Cliby ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
High Risk ◽  
Sentinel Lymph Node ◽  
Tumor Cells ◽  
Gynecologic Oncology ◽  
Gynecologic Cancer ◽  
Cancer Staging ◽  
Isolated Tumor Cells ◽  
Factors Influencing

ObjectiveTo explore the factors influencing adoption of the sentinel lymph node (SLN) technique for endometrial cancer staging among gynecologic oncologists.MethodsA self-administered, web-based survey was sent via email (April 20 through May 21, 2017) to all members of European Society of Gynecologic Oncologists, International Gynecologic Cancer Society, and Society of Gynecologic Oncologists. Surgical and pathologic practices related to SLN and reasons for not adopting this technique were investigated.ResultsOverall, 489 attending physicians or consultants in gynecologic oncology from 69 countries responded: 201 (41.1%), 118 (24.1%), and 117 (23.9%) from Europe, the USA, and other countries, respectively (10.8% did not report a country). SLN was adopted by 246 (50.3%) respondents, with 93.1% injecting the cervix and 62.6 % using indocyanine green dye. The National Comprehensive Cancer Network SLN algorithm was followed by 160 (65.0%) respondents (USA 74.4%, Europe 55.4%, other countries 71.4%). However, 66.7% completed a backup lymphadenectomy in high-risk patients. When SLN biopsy revealed isolated tumor cells, 13.8% of respondents recommended adjuvant therapy. This percentage increased to 52% if micrometastases were detected. Among the 243 not adopting SLN, 50.2% cited lack of evidence and 45.3% stated that inadequate instrumentation fueled their decisions.ConclusionsSLN with a cervical injection is gaining widespread acceptance for staging of endometrial cancer among gynecologic oncologists worldwide. Standardization of the surgical approach with the National Comprehensive Care Network algorithm is applied by most users. Management of isolated tumor cells and the role of backup lymphadenectomy for ‘high-risk’ cases remain areas of investigation.

Isolated tumor cells versus micro-metastasis in sentinel lymph node biopsy for T1, T2 breast cancer compared to macro-metastasis: Significance after complete axillary dissection

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e12028-e12028
Author(s):  
Y. A. Alabdulkarim ◽  
E. Nassif
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Tumor Cells ◽  
Axillary Dissection ◽  
Lymph Node Biopsy ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Isolated Tumor Cells ◽  
Lymph Node Examination

e12028 Background: Evaluating the axillary lymph nodes is extremely important in the management of breast cancer, with the recent improvement in histopathology techniques detection of micro-metastasis and even isolated cancer cells (ITC) in a setting of sentinel lymph node examination is feasible. In this study we aim to compare the outcome and significance of; positive SLN for macro versus Micro-metastasis, and ITCs. Methods: We reviewed all the patients who had SLN for breast cancer of stage T 1–2 between April 2006 and November 2008. Identifying all those who had positive macro-metastasis, micro-metastasis, or isolated tumor cells, pathology results of the full axillary LN dissection was evaluated for each type. Results: 350 patients had SLN of these 226 had a disease of T1–2, thirty seven patients (16.3%) had full axillary dissection, of these 27/37 had positive SLN for macro-metastasis, six had micro-metastasis and 3/37 had only ITCs. The presence of other LN metastasis was detected in 8 cases (21.6%); all of them were in the macro-metastasis group. No metastasis was found in either the micro-metastasis or the ITC groups. The ITC was only detected with DCIS; while micro-metastasis was present in DCIS or IDC. No relation was identified between the histopathology grade with ITC or micro-metastasis. Conclusions: Our findings did not show any presence of lymphatic metastasis after full axillary dissection, in case of positive micro-metastasis or ITCs in SLN, compared to the group of macro-metastasis. No significant financial relationships to disclose.

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