O47 The prognostic impact of bone invasion in squamous cell carcinoma of the oral cavity

2007 ◽  
Vol 2 (1) ◽  
pp. 71
Author(s):  
R. Pate ◽  
K. Gao ◽  
J. Clark ◽  
C. O'Brien
2022 ◽  
Vol 43 (2) ◽  
pp. 103303
Author(s):  
Gaelen B. Stanford-Moore ◽  
Ana Marija Sola ◽  
Jason Chan ◽  
Ivan El-Sayed ◽  
Jonathan George ◽  
...  

2019 ◽  
Vol 8 (14) ◽  
pp. 6185-6194 ◽  
Author(s):  
Li‐Yu Lee ◽  
Dante De Paz ◽  
Chien‐Yu Lin ◽  
Kang‐Hsing Fan ◽  
Hung‐Ming Wang ◽  
...  

2019 ◽  
Vol 8 (4) ◽  
Author(s):  
Thyago Leite Campos de Campos de Araújo ◽  
Júlio Leite de Araújo Júnior ◽  
Emanuelle de Abreu Moreira Vieira

Introdução: No território brasileiro, a localização anatômica com maior incidência de lesões cancerígenas é em cabeça e pescoço. Sendo caracterizadas como mais agressivas, as lesões localizadas na boca e orofaringe. Afetando, principalmente a capacidade de deglutir e mastigar, no bem estar emocional, na dor e na comunicação. Estes efeitos decorrem da própria doença ou tipo e agressividade do tratamento, gradualmente mais deformantes quando mais tardio o diagnóstico. Objetivo: O presente estudo tem por objetivo relatar um caso de carcinoma in sito em cavidade bucal e orofaringe bem como apresentar uma breve revisão de literatura sobre neoplasias malignas de boca e orofaringe de maior frequência bem como caracterizá-lo clinicamente e alertar sobre os benefícios do diagnóstico precoce. Relato de caso: Paciente, 64 anos, feminina, melanoderma, apresentando lesão eritroplásica em soalho lingual, bordo lateral de língua com extensão para palato mole. Tabagista há 46 anos apresentando ao exame de macroscopia fragmento de tecido mole de formato e superfícies irregulares, consistência elástica, coloração branco acastanhada, medindo em conjunto 1,2 x1,0x 0,5 cm. O exame histopatológico revelou Carcinoma “in situ”. Diante do diagnóstico, a paciente foi encaminhada para o tratamento especializado no hospital de referência na região do Cariri. Conclusão: Conclui-se que o exame clínico minucioso da cavidade oral dos pacientes com fatores de risco 2 e/ou que possuam lesões suspeitas é de fundamental importância para profissionais como o Cirurgião-Dentista e Médico.Descritores: Câncer; Boca; Orofaringe; Odontologia.ReferênciasGupta B, Bhattacharyya A, Singh A, Sah K, Gupta V. Basaloid squamous cell carcinoma - A rare and aggressive variant of squamous cell carcinoma: A case report and review of literature. Natl J Maxillofac Surg. 2018;9(1):64-8.Heera R, Ayswarya T, Padmakumar SK, Ismayil P. Basaloid squamous cell carcinoma of oral cavity: Report of two cases. J Oral Maxillofac Pathol. 2016;20(3):545Tomblinson CM, Nagel TH, Hu LS, Zarka MA, Hoxworth JM. Median lingual lymph nodes: prevalence on imaging and potential implications for oral cavity cancer staging. J Comput Assist Tomogr. 2017;41(4):528-34.Varela-Centelles P, López-Cedrun JL, Fernández-Sanromán J, Seone-Romero JM, Santos de Melo N, Álvarez-Nóvoa P  et al. Key points and time intervals for early diagnosis in symptomatic oral cancer: A systematic review. Int J Oral Maxillofac Surg. 2017;46(1):1-10.Jia J, Jia MQ, Zou HX. Lingual lymph nodes in patients with squamous cell carcinoma of the tongue and the floor of the mouth. Head Neck. 2018;40(11):2383-88.Swiecicki PL, Malloy KM, Worden FP. Advanced oropharyngeal squamous cell carcinoma: Pathogenesis, treatment, and novel therapeutic approaches. World J Clin Oncol. 2016;7(1):15-26.Balica NC, Poenaru M, Doroş CI, Baderca F, Preda MA, Iovan VC et al.The management of the oropharyngeal anterior wall cancer. Rom J Morphol Embryol. 2018;59(1):113-19.Dahlstrom KR, Bell D, Hanby D, Li G, Wang LE, Wei Q et al. Socioeconomic characteristics of patients with oropharyngeal carcinoma according to tumor HPV status, patient smoking status, and sexual behavior. Oral Oncol. 2015;51(9):832-38.Bonomo P, Merlotti A, Olmetto E, Bianchi A, Desideri I, Bacigalupo A et al. What is the prognostic impact of FDG PET in locally advanced head and neck squamous cellcarcinoma treated with concomitant chemo-radiotherapy? A systematic review and meta-analysis. Eur J Nucl Med Mol Imaging. 2018;45(12):2122-38.Picard A, Arowas L, Piroth L, Heard I, Ferry T, ORL-HIV-HPV studt group. Head and neck squamous cell carcinoma in people living with HIV in France. Med Mal Infect. 2018;48(8):503-8.


2017 ◽  
Vol 45 (2) ◽  
pp. 252-257 ◽  
Author(s):  
Ivana Petrovic ◽  
Pablo H. Montero ◽  
Jocelyn C. Migliacci ◽  
Frank L. Palmer ◽  
Ian Ganly ◽  
...  

Head & Neck ◽  
2013 ◽  
Vol 36 (6) ◽  
pp. 776-781 ◽  
Author(s):  
David Fried ◽  
Brandon Mullins ◽  
Mark Weissler ◽  
Carol Shores ◽  
Adam Zanation ◽  
...  

2021 ◽  
Vol 11 (9) ◽  
pp. 936
Author(s):  
Chun-Hou Huang ◽  
Peir-Rorg Chen ◽  
Kun-Han Lue ◽  
Tsung-Cheng Hsieh ◽  
Yu-Fu Chou

In this study, we aimed to evaluate the prognostic impact of sarcopenia, five-item modified frailty index (mFI-5), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) in patients with oral cavity squamous cell carcinoma (OSCC) treated with adjuvant chemoradiotherapy (CRT) and their survival outcomes. We retrospectively enrolled 175 patients with OSCC undergoing adjuvant CRT between 2011 and 2018, who were divided into groups with (n = 112) and without (n = 63) sarcopenia. Logistic regression analysis and Cox proportional hazards models were used to determine prognostic factors for CRT-related toxicity, three-year overall survival (OS), and disease-free survival (DFS). Sarcopenia and high PLR were independently associated with CRT-induced anemia (CIA); advanced tumor stage was related to poor three-year OS. CRT and survival did not differ by mFI-5 and NLR. Our results indicate that sarcopenia and high PLR are significant predictors of adjuvant CRT, increasing toxicity outcomes and indicating worse short-term OS. Accurately identifying sarcopenia and high PLR in patients with OSCC is critical to help better select candidates for adjuvant CRT to improve their outcomes.


Author(s):  
Amrit Kaur Kaler, Shweta C, Smitha Chandra B.C, Rajeev Naik

Spindle cell carcinoma is a rare aggressive biphasic tumor, composed of neoplastic proliferation of both epithelial (squamous) and spindle cell population. It constitutes about 1% of all oral cavity tumors 2a and is almost rare on the tongue; only few cases have been reported so far. This variant of squamous cell carcinoma, comprises major diagnostic problems due to its varied histomorphology and resemblance to sarcomatous lesion; hence diligent screening and IHC markers are mandatory for its diagnosis.


2020 ◽  
Vol 25 (4) ◽  
pp. 287-294
Author(s):  
S. I. Kutukova ◽  
N. P. Beliak ◽  
G. A. Raskin ◽  
M. S. Mukhina ◽  
Yu. V. Ivaskova ◽  
...  

Relevance. Prognostic value of PD-L1 expression in oral cavity squamous cell carcinoma (OCSCC) and its effect on survival is still controversial. It should be to determine the prognostic role of PD-L1 expression on tumor and immune cells of OCSCC and assess their effect on overall survival (OS) and progression-free survival (PFS).Materials and methods. A prospective study included 145 patients, first diagnosed with OCSCC. PD-L1 expression on tumor and immune cells, infiltrating tumor and its microenvironment, was assessed in all tumor samples by IHC, CPS was calculated. Cut-off values were determined by ROC analysis for identification of PD-L1 expression effect on OS and PFS.Results. Most patients with oral mucosa squamous cell carcinoma showed positive expression of PD-L1 on tumor (77.2%) and immune cells (92.4%). The median PD-L1 expression on tumor cells was 13.5% [1.0-40.0], the median PD-L1 expression on immune cells was 5.0% [1.0-11.0], and the median CPS – 18.0 [3.0-7.8]. Univariate and multivariate analyses revealed a significant negative effect of PD-L1 expression on immune cells ≤ 7% on OS (HR 0.66; 95% CI 0.45-0.93; p = 0.0498); PD-L1 expression in tumor cells ≤ 15% (HR 0.65; 95% CI 0.43-0.98; p = 0.0416) and CPS ≤ 21 (HR 0.62; 95% CI 0.44-0.92; p = 0.0183) for PFS. PD-L1 expression in tumor cells ≤ 6% (HR 0.71; 95% CI 0.47-1.08; p = 0.1096) and CPS ≤ 7 (RR 0.67; 95% CI 0.44-1.01; p = 0.0575) had a confident tendency to negative impact on OS.Conclusion. Positive PD-L1 expression in tumor and immune cells as well as CPS are effective additional factors in the prognosis of the disease course, OS and PFS in patients with OCSCC.


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