Optimized double emulsion-solvent evaporation process for production of solid lipid nanoparticles containing baclofene as a lipid insoluble drug

2013 ◽  
Vol 23 (3) ◽  
pp. 225-230 ◽  
Author(s):  
M. Nabi-Meibodi ◽  
B. Navidi ◽  
N. Navidi ◽  
A. Vatanara ◽  
M. Reza Rouini ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Double Emulsion ◽  
Lipid Nanoparticles ◽  
Solvent Evaporation ◽  
Evaporation Process ◽  
Solid Lipid ◽  
Solvent Evaporation Process

Solid Lipid Nanoparticles: A Promising Nanomaterial in Drug Delivery

2019 ◽  
Vol 25 (37) ◽  
pp. 3943-3959 ◽  
Author(s):  
Kuldeep Rajpoot
Keyword(s):  
Solid Lipid Nanoparticles ◽  
High Speed ◽  
Double Emulsion ◽  
Lipid Nanoparticles ◽  
Suitable Candidate ◽  
Pharmaceutical Ingredients ◽  
Solid Lipid ◽  
Drug Molecules ◽  
Efficient Delivery ◽  
Specific Ligand

The solid lipid nanoparticles (SLNs) usually consists of active drug molecules along with solid lipids, surfactants, and/or co-surfactants. They possess some potential features such as nano-size, surface with a free functional group to attach ligands, and as well they prove safe homing for both lipophilic as well as hydrophilic molecules. As far as synthesis is concerned, SLNs can be prepared by employing various techniques viz., homogenization techniques (e.g., high-pressure, high-speed, cold, or hot homogenization), spray drying technique, ultrasonication, solvent emulsification, double emulsion technique, etc. Apart from this, they are characterized by different methods for determining various parameters like particle-size, polydispersity-index, surface morphology, DSC, XRD, etc. SLNs show good stability as well as the ability for surface tailoring with the specific ligand, which makes them a suitable candidate in the therapy of numerous illnesses, especially in the targeting of the cancers. In spite of this, SLNs have witnessed their application via various routes e.g., oral, parenteral, topical, pulmonary, rectal routes, etc. Eventually, SLNs have also shown great potential for delivery of gene/DNA, vaccines, as well as in cosmeceuticals. Hence, SLNs have emerged as a promising nanomaterial for efficient delivery of various Active Pharmaceutical Ingredients (APIs).

A meso-macro compartmentalized bioreactor obtained through silicalization of “green” double emulsions: W/O/W and W/SLNs/W

2014 ◽  
Vol 50 (80) ◽  
pp. 11871-11874 ◽  
Author(s):  
Jean-Luc Blin ◽  
Jonathan Jacoby ◽  
Sanghoon Kim ◽  
Marie-José Stébé ◽  
Nadia Canilho ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Double Emulsion ◽  
Lipid Nanoparticles ◽  
Double Emulsions ◽  
Solid Lipid ◽  
Silica Materials ◽  
Hexagonally Ordered ◽  
Straightforward Approach ◽  
Ordered Mesopores

We report a straightforward approach for both structuring and entrapping enzymes into hierarchical silica materials with hexagonally ordered mesopores and tailored macroporosity by converting a double emulsion colloidal template into solid lipid nanoparticles.

Diclofenac sodium-loaded solid lipid nanoparticles prepared by emulsion/solvent evaporation method

2010 ◽  
Vol 13 (6) ◽  
pp. 2375-2386 ◽  
Author(s):  
Dongfei Liu ◽  
Sunmin Jiang ◽  
Hong Shen ◽  
Shan Qin ◽  
Juanjuan Liu ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Diclofenac Sodium ◽  
Lipid Nanoparticles ◽  
Solvent Evaporation ◽  
Solvent Evaporation Method ◽  
Evaporation Method ◽  
Solid Lipid

scholarly journals Doxycycline-encapsulated solid lipid nanoparticles for the enhanced antibacterial potential to treat the chronic brucellosis and preventing its relapse: in vivo study

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Seyed Mostafa Hosseini ◽  
Abbas Farmany ◽  
Roghayyeh Abbasalipourkabir ◽  
Sara Soleimani Asl ◽  
Alireza Nourian ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Brucella Melitensis ◽  
Double Emulsion ◽  
Wistar Rat ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Main Challenge ◽  
Large Period ◽  
Antibacterial Potential

Abstract Background Brucellosis is one of the most important infection of diseases. Due to its large period of treatment and survival ability of bacteria inside the macrophages, relapse of this disease is the main challenge, especially, after the treatment. Objective The current study was carried out to evaluate the antibacterial effect of solid lipid nanoparticles loaded with doxycycline on the Brucella melitensis in in vivo conditions. Methods The double emulsion synthesized doxycycline-encapsulated solid lipid nanoparticles (DOX-SLN) was characterized using DLS and FE-SEM. The efficacy of the DOX-SLN on the acute and chronic Wistar rat infected brucellosis was investigated. The pathological assessments were made on the spleen and liver in the treated rates. Results The in vivo experimental results demonstrated that the treated rats with DOX-SLN had significantly decreased the B. melitensis CFUs in their spleen and liver compared to that of the treated rates with free doxycycline and untreated ones. The pathologic results indicate that the improvement trend of spleen and liver tissues in rats treated by DOX-SLN was satisfactory. Conclusion According to in vivo results, the DOX-SLN has better effects on the treatment of chronic brucellosis. Therefore, DOX-SLN is recommended to treat the brucellosis and avoid its relapse.

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