Effects of Surfactants and Lipids on the Preparation of Solid Lipid Nanoparticles Using Double Emulsion Method

The solid lipid nanoparticles (SLNs) usually consists of active drug molecules along with solid lipids, surfactants, and/or co-surfactants. They possess some potential features such as nano-size, surface with a free functional group to attach ligands, and as well they prove safe homing for both lipophilic as well as hydrophilic molecules. As far as synthesis is concerned, SLNs can be prepared by employing various techniques viz., homogenization techniques (e.g., high-pressure, high-speed, cold, or hot homogenization), spray drying technique, ultrasonication, solvent emulsification, double emulsion technique, etc. Apart from this, they are characterized by different methods for determining various parameters like particle-size, polydispersity-index, surface morphology, DSC, XRD, etc. SLNs show good stability as well as the ability for surface tailoring with the specific ligand, which makes them a suitable candidate in the therapy of numerous illnesses, especially in the targeting of the cancers. In spite of this, SLNs have witnessed their application via various routes e.g., oral, parenteral, topical, pulmonary, rectal routes, etc. Eventually, SLNs have also shown great potential for delivery of gene/DNA, vaccines, as well as in cosmeceuticals. Hence, SLNs have emerged as a promising nanomaterial for efficient delivery of various Active Pharmaceutical Ingredients (APIs).

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A meso-macro compartmentalized bioreactor obtained through silicalization of “green” double emulsions: W/O/W and W/SLNs/W

Chemical Communications ◽

10.1039/c4cc06007e ◽

2014 ◽

Vol 50 (80) ◽

pp. 11871-11874 ◽

Cited By ~ 12

Author(s):

Jean-Luc Blin ◽

Jonathan Jacoby ◽

Sanghoon Kim ◽

Marie-José Stébé ◽

Nadia Canilho ◽

...

Keyword(s):

Solid Lipid Nanoparticles ◽

Double Emulsion ◽

Lipid Nanoparticles ◽

Double Emulsions ◽

Solid Lipid ◽

Silica Materials ◽

Hexagonally Ordered ◽

Straightforward Approach ◽

Ordered Mesopores

We report a straightforward approach for both structuring and entrapping enzymes into hierarchical silica materials with hexagonally ordered mesopores and tailored macroporosity by converting a double emulsion colloidal template into solid lipid nanoparticles.

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Doxycycline-encapsulated solid lipid nanoparticles for the enhanced antibacterial potential to treat the chronic brucellosis and preventing its relapse: in vivo study

Annals of Clinical Microbiology and Antimicrobials ◽

10.1186/s12941-019-0333-x ◽

2019 ◽

Vol 18 (1) ◽

Author(s):

Seyed Mostafa Hosseini ◽

Abbas Farmany ◽

Roghayyeh Abbasalipourkabir ◽

Sara Soleimani Asl ◽

Alireza Nourian ◽

...

Keyword(s):

Solid Lipid Nanoparticles ◽

Brucella Melitensis ◽

Double Emulsion ◽

Wistar Rat ◽

Lipid Nanoparticles ◽

Solid Lipid ◽

Main Challenge ◽

Large Period ◽

Antibacterial Potential

Abstract Background Brucellosis is one of the most important infection of diseases. Due to its large period of treatment and survival ability of bacteria inside the macrophages, relapse of this disease is the main challenge, especially, after the treatment. Objective The current study was carried out to evaluate the antibacterial effect of solid lipid nanoparticles loaded with doxycycline on the Brucella melitensis in in vivo conditions. Methods The double emulsion synthesized doxycycline-encapsulated solid lipid nanoparticles (DOX-SLN) was characterized using DLS and FE-SEM. The efficacy of the DOX-SLN on the acute and chronic Wistar rat infected brucellosis was investigated. The pathological assessments were made on the spleen and liver in the treated rates. Results The in vivo experimental results demonstrated that the treated rats with DOX-SLN had significantly decreased the B. melitensis CFUs in their spleen and liver compared to that of the treated rates with free doxycycline and untreated ones. The pathologic results indicate that the improvement trend of spleen and liver tissues in rats treated by DOX-SLN was satisfactory. Conclusion According to in vivo results, the DOX-SLN has better effects on the treatment of chronic brucellosis. Therefore, DOX-SLN is recommended to treat the brucellosis and avoid its relapse.

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Solid lipid nanoparticles for encapsulation of hydrophilic drugs by an organic solvent free double emulsion technique

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2015.12.033 ◽

2016 ◽

Vol 140 ◽

pp. 317-323 ◽

Cited By ~ 37

Author(s):

Luana Becker Peres ◽

Laize Becker Peres ◽

Pedro Henrique Hermes de Araújo ◽

Claudia Sayer

Keyword(s):

Organic Solvent ◽

Solid Lipid Nanoparticles ◽

Double Emulsion ◽

Lipid Nanoparticles ◽

Solvent Free ◽

Emulsion Technique ◽

Hydrophilic Drugs ◽

Solid Lipid

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Design and Characterization of Elastic Artificial Skin Containing Adenosine-Loaded Solid Lipid Nanoparticles for Treating Wrinkles

Pharmaceutics ◽

10.3390/pharmaceutics13010033 ◽

2020 ◽

Vol 13 (1) ◽

pp. 33

Author(s):

Sooho Yeo ◽

Sukkyun Jung ◽

Heui Kyoung Cho ◽

Young Ho Kim ◽

Gi Hwan Kim ◽

...

Keyword(s):

Solid Lipid Nanoparticles ◽

Skin Permeation ◽

Double Emulsion ◽

Lipid Nanoparticles ◽

Artificial Skin ◽

Sustained Drug Release ◽

Solid Lipid ◽

The Mean ◽

Skin Wrinkles

Adenosine (AD), which is used for treating wrinkles, exhibits poor skin permeation. The aim of the present study was to develop a cross-linked silicone-based cellulose elastomer as an elastic artificial skin for the treatment of skin wrinkles, a biocompatible lipid-based nano-carrier for enhancing the skin permeation of AD, and a formulation consisting of the lipid-based carrier incorporated in the elastic artificial skin. AD-loaded solid lipid nanoparticles (SLNs) were prepared using a double-emulsion method. Particle characteristics and mechanical properties of SLNs and elastic artificial skin, respectively, were assessed. Skin permeation was evaluated using SkinEthic RHE tissue, a reconstructed human epidermis model. The mean particle size and zeta potential for SLNs ranged from 123.57 to 248.90 nm and −13.23 to −41.23 mV, respectively. The components of neither SLNs nor the elastic artificial skin were cytotoxic, according to cell- and tissue-viability assays and EU classification. SLNs and the elastic artificial skin exhibited sustained drug release for 48 h. The amount of AD released from SLNs and elastic artificial skin was approximately 10 times and 5 times higher, respectively, than that from AD solution. Therefore, elastic artificial skin incorporated with AD-loaded SLNs may serve as a promising topical delivery system for cosmeceutical treatment of skin wrinkles.

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