Synthesis and chemical characterization of new silica polyethylene glycol hybrid nanocomposite materials for controlled drug delivery

2014 ◽  
Vol 24 (4) ◽  
pp. 320-325 ◽  
Author(s):  
M. Catauro ◽  
F. Bollino ◽  
F. Papale ◽  
M. Gallicchio ◽  
S. Pacifico
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Chemical Characterization ◽  
Controlled Drug Delivery ◽  
Nanocomposite Materials ◽  
Hybrid Nanocomposite

Synthesis and Characterization of pH Tolerant and Mucoadhesive (Thiol–Polyethylene Glycol) Chitosan Graft Polymer for Drug Delivery

2014 ◽  
Vol 103 (2) ◽  
pp. 594-601 ◽  
Author(s):  
Sabine Hauptstein ◽  
Sonja Bonengel ◽  
Julia Griessinger ◽  
Andreas Bernkop-Schnürch
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Synthesis And Characterization ◽  
Graft Polymer ◽  
Glycol Chitosan

scholarly journals Synthesis and Characterization of Methotrexate Polyethylene Glycol Esters as a Drug Delivery System

2010 ◽  
Vol 58 (2) ◽  
pp. 147-153 ◽  
Author(s):  
Gholamhossein Yousefi ◽  
Seyed Mohsen Foroutan ◽  
Afshin Zarghi ◽  
Alireza Shafaati
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Drug Delivery System ◽  
Delivery System ◽  
Synthesis And Characterization

Preparation and Characterization of Copolymeric Polymersomes for Protein Delivery

Drug Research ◽  
2017 ◽  
Vol 67 (08) ◽  
pp. 458-465 ◽  
Author(s):  
Alireza Nomani ◽  
Hamed Nosrati ◽  
Hamidreza Manjili ◽  
Leila Khesalpour ◽  
Hossein Danafar
Keyword(s):  
Drug Delivery ◽  
Protein Delivery ◽  
Encapsulation Efficiency ◽  
Controlled Drug Delivery ◽  
Protein Polymer ◽  
Biodegradable Copolymers ◽  
Model Protein ◽  
Sustained Protein Release ◽  
Polymer Ratio

AbstractBiodegradable copolymeric polymersomes have been used for controlled drug delivery of proteins. These polymersomes important areas to overcome formulation associated problems of the proteins. The aim of this study was to develop polymersomes using biodegradable copolymers for delivery of bovine serum albumin (BSA) as a model protein. Encapsulated BSA by mPEG-PCL polymersomes led to formation of BSA-loaded mPEG-PCL polymersomes. The polymersomes synthesized with the protein-polymer ratio of 1:4 at 15 000 rpm gave maximum loading, minimum polydispersion with maximally sustained protein release pattern, among the prepared polymersomes. Investigation on FTIR and DSC results revealed that such a high encapsulation efficiency is due to strong interaction between BSA and the copolymer.The particles size and their morphology of polymersomes were determined by DLS and AFM.The encapsulation efficiency of BSA was 91.02%. The results of AFM showed that the polymersomes had spherical shapes with size of 49 nm.The sizes of BSA-loaded polymersomes ranged from 66.06 nm to 84.97 nm. The results showed that polymersomes exhibited a triphasic release, for BSA. Overall, the results indicated that mPEG–PCL polymersomes can be considered as a promising carrier for proteins.

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