Chemical ecology-driven discovery of bioactive marine natural products as potential drug leads

: Respiratory viruses, including influenza virus, respiratory syncytial virus, coronavirus, et al., have seriously threatened the human health. For example, the outbreak of severe acute respiratory syndrome coronavirus, SARS, affected a large number of countries around the world. Marine organisms, which could produce secondary metabolites with novel structures and abundant biological activities, are an important source for seeking effective drugs against respiratory viruses. This report reviews marine natural products with activities against respiratory viruses, the emphasis of which was put on structures and antiviral activities of these natural products. This review has described 167 marine-derived secondary metabolites with activities against respiratory viruses published during 1981 to 2019. Altogether 102 references are cited in this review article.

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A Review of the Secondary Metabolites From the Marine Sponges of the Genus Aaptos

Natural Product Communications ◽

10.1177/1934578x20951439 ◽

2020 ◽

Vol 15 (9) ◽

pp. 1934578X2095143

Author(s):

Qianqian He ◽

Shuang Miao ◽

Na Ni ◽

Yuqing Man ◽

Kaikai Gong

Keyword(s):

Natural Products ◽

Secondary Metabolites ◽

Natural Product ◽

Chemical Ecology ◽

Marine Natural Products ◽

Organic Molecules ◽

Biological Activities ◽

Marine Sponges ◽

Marine Natural Product ◽

Natural Product Research

Marine sponges, which belong to the phylum Porifera (Metazoa), are considered the single best source of marine natural products. Among them, members of the genus Aaptos are attractive targets for marine natural product research owing to their abundant biogenetic ability to produce aaptamine derivatives. Apart from aaptamine alkaloids, there are also reports of other compounds from Aaptos sponges. This work reviews the secondary metabolites isolated from Aaptos species from 1982 to 2020, with 46 citations referring to 62 compounds (47 for aaptamines and 15 for others). The emphasis is placed on the structure of the organic molecules, relevant biological activities, chemical ecology aspects, and biosynthesis studies, which are described in the classifications of aaptamines and other compounds in the order of the published year.

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Thiazole: A Privileged Motif in Marine Natural Products

Mini-Reviews in Organic Chemistry ◽

10.2174/1570193x15666180412152743 ◽

2018 ◽

Vol 16 (1) ◽

pp. 26-34 ◽

Cited By ~ 9

Author(s):

Sunil Kumar ◽

Ranjana Aggarwal

Keyword(s):

Natural Products ◽

Biological Activity ◽

Secondary Metabolites ◽

Marine Natural Products ◽

Biological Activities ◽

Thiazole Ring ◽

Cytotoxic Activities ◽

Marine Microorganisms ◽

Thiazole Derivatives ◽

Drug Leads

Marine natural products have proven to be a rich source of drugs and drug leads. These natural products are secondary metabolites and show biological activity against bacteria, fungi and viruses. Natural products containing thiazole ring occur often in marine sources. They exhibit diverse and remarkable biological activities, including antitumor, antibacterial, anti-inflammatory and cytotoxic activities, to name a few. This review surveys the natural thiazole derivatives that have been isolated from marine microorganisms, with emphasis on biological implications in last three decades.

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