013: Association between inflammatory markers, mean platelet volume and traditional risk factors in patients with documented coronary artery spasm

Aim.To identify the effect of preprocedural laboratory parameters on the occurrence of in-stent restenosis in various types of stents, to assess the significance of gender, age and various forms of coronary artery disease (CAD) as risk factors for coronary artery restenosis after stenting.Material and methods.The study included 436 patients with CAD, which were divided into 2 groups. The study group included 218 patients with in-stent restenosis. The control group consisted of 218 patients with CAD without in-stent restenosis. Inclusion criteria were acute or chronic form of CAD, age 45-74 years, CAG and percutaneous coronary intervention (PCI) with emergency or planned stenting of the native coronary artery, repeated CAG in history due to signs/symptoms of myocardial ischemia. Exclusion criteria: age younger than 45 years and over 74 years, coronary artery bypass surgery (CABG), cancer, autoimmune disease, anemia, liver failure, chronic kidney disease S4-S5, recent blood transfusion, hypo-or hyperthyroidism.Results.According to the study, the risk in-stent restenosis is 5,2 times higher in patients in the 65-69 years age group and 9,9 times higher in the 70-74 years age group compared with the group of young patients (45-49 years). In-stent restenosis is 2,7 times more common in men than in women. Predictors of restenosis were red cell distribution width, mean platelet volume, Gensini score with OR 1,5; 1,4; 1,1; 1,5, respectively.Conclusion.Risk factors for coronary artery restenosis after stenting are markers of chronic inflammation, such as the red cell distribution width, mean platelet volume. The risk of restenosis is higher in the male population. In old age, the risk of restenosis increases, however, young people and middle-aged people do not differ in risk of in-stent restenosis.

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PP-213 MEAN PLATELET VOLUME IS ASSOCIATED WITH CORONARY ARTERY DISEASE AND CARDIOVASCULAR RISK FACTORS, BUT PLATELET DISTRIBUTION WIDTH IS NOT

International Journal of Cardiology ◽

10.1016/s0167-5273(13)70417-0 ◽

2013 ◽

Vol 163 (3) ◽

pp. S165

Author(s):

A.G. Ertem ◽

S. Namdaroglu ◽

E. Sennaroglu ◽

T.H. Efe

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Cardiovascular Risk ◽

Coronary Artery ◽

Cardiovascular Risk Factors ◽

Mean Platelet Volume ◽

Platelet Distribution Width ◽

Platelet Volume ◽

Distribution Width ◽

Artery Disease

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Association between mean platelet volume with risk factors of myocardial infarction

Medpusle International Journal of Medicine ◽

10.26611/10211428 ◽

2020 ◽

Vol 14 (2) ◽

pp. 59-64

Author(s):

Ranjith K ◽

◽

Ganesh Jadhao ◽

Keyword(s):

Risk Factors ◽

Myocardial Infarction ◽

Mean Platelet Volume ◽

Platelet Volume

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Association of Plasma MiRNA-204 and the Presence and Severity of Coronary Artery Calcification in Patients With Type 2 Diabetes

Angiology ◽

10.1177/0003319720984592 ◽

2021 ◽

pp. 000331972098459

Author(s):

Yao-dong Ding ◽

Yu-qiang Pei ◽

Rui-Wang ◽

Jia-xin Yang ◽

Ying-xin Zhao ◽

...

Keyword(s):

Risk Factors ◽

Type 2 Diabetes ◽

Coronary Artery ◽

Coronary Artery Calcification ◽

Characteristic Curve ◽

Glycosylated Hemoglobin ◽

The United Kingdom ◽

Traditional Risk Factors ◽

Plasma Microrna

We investigated the association between plasma microRNA (miR)-204 and coronary artery calcification (CAC) in patients with type 2 diabetes mellitus (T2DM). We consecutively enrolled 179 individuals with T2DM who underwent coronary computed tomography at Anzhen Hospital from January 2015 to September 2016. The CAC score (CACS) was expressed in Agatston units and >10 Hounsfield units were defined as CAC-positive status. Significant CAC was observed in 98 (54.7%) patients. Plasma miR-204 levels (relative expression) were significantly lower in patients with significant CAC than controls (1.001 ± 0.100 vs 0.634 ± 0.211, P < .001). Plasma miR-204 levels were also negatively correlated with the glycosylated hemoglobin A1c (HbA1c) level (r = −0.702, P < .001), CACS (r = −0.710, P < .001), and the United Kingdom Prospective Diabetes Study (UKPDS) score (r = −0.355, P < .001). After multivariate logistic analyses, plasma miR-204 levels were still significantly and independently associated with the presence of CAC (odds ratio = 0.103, CI = 0.018-0.583, P < .001) after adjustment for conventional risk factors. Receiver operating characteristic curve analysis showed that plasma miR-204 levels can predict the severity and extent of CAC, and the specificity was higher than that of the traditional risk factors UKPDS score and HbA1c. In conclusion, the downregulation of miR-204 was independently associated with CAC in patients with T2DM.

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Incremental prognostic value of visually estimated coronary artery calcium in patients undergoing positron emission tomography imaging

Open Heart ◽

10.1136/openhrt-2021-001648 ◽

2021 ◽

Vol 8 (1) ◽

pp. e001648

Author(s):

Senthil Selvaraj ◽

Muhammad Shoaib Khan ◽

Mahesh K Vidula ◽

Philip C Wiener ◽

Alejandro E de Feria ◽

...

Keyword(s):

Risk Factors ◽

Positron Emission Tomography ◽

Coronary Artery ◽

Pet Imaging ◽

Prognostic Value ◽

Primary Outcome ◽

Chest Ct ◽

Emission Tomography ◽

Positron Emission ◽

Traditional Risk Factors

ObjectiveVisually estimated coronary artery calcium (VECAC) from chest CT or attenuation correction (AC)/CT obtained during positron emission tomography (PET)–myocardial perfusion imaging (MPI) is feasible. Our aim was to determine the prognostic value of VECAC beyond conventional risk factors and PET imaging parameters, including coronary flow reserve (CFR).MethodsWe analysed 608 patients without known coronary artery disease who underwent PET–MPI between 2012 and 2016 and had AC/CT and/or chest CT images. We used Cox regression to estimate the association of VECAC categories (≤10, 11–400, >400 Agatston units (AU)) with the primary outcome of all-cause death, acute coronary syndrome or stroke (mean follow-up 4.3±1.8 years). C-statistics assessed the relationship between PET parameters and VECAC with the primary outcome.ResultsMean age was 58±11 years, 65% were women and 67% were black. VECAC ≤10, 11–400 and >400 AU was observed in 68%, 12% and 20% of subjects, respectively. Compared with VECAC ≤10, VECAC categories 11–400 (HR 2.25, 95% CI 1.24 to 4.08) and >400 AU (HR 3.05, 95% CI 1.87 to 4.98) were associated with the primary outcome after adjusting for traditional risk factors, MPI findings and CFR. Adding VECAC to a model that included PET–MPI, CFR and clinical risk factors improved the prognostic value for the primary outcomes (c-statistic 0.71 to 0.75 with VECAC, p=0.01).ConclusionsVECAC is a potent predictor of events beyond traditional risk factors and PET imaging markers, including CFR. These data further support the importance for routine VECAC implementation.

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