scholarly journals Increased expression and phosphorylation of SAMHD1 in SIV and HIV encephalitis is associated with proliferation of brain macrophages

2017 ◽  
Vol 3 ◽  
pp. 13
Author(s):  
A.A. Lindgren ◽  
A.R. Filipowicz ◽  
J.B. Hattler ◽  
S. Ok Kim ◽  
H.K. Chung ◽  
...  
Keyword(s):  
Brain Macrophages ◽  
Hiv Encephalitis

Influence of risk group and zidovudine therapy on the development of HIV encephalitis and cognitive impairment in AIDS patients

AIDS ◽  
1996 ◽  
Vol 10 (5) ◽  
pp. 493-499 ◽  
Author(s):  
Jeanne E. Bell ◽  
Yvonne K. Donaldson ◽  
Suzanne Lowrie ◽  
Chris Anne McKenzie ◽  
Rob A. Elton ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Risk Group ◽  
Zidovudine Therapy ◽  
Hiv Encephalitis ◽  
Aids Patients

scholarly journals Comparative analysis of CreER transgenic mice for the study of brain macrophages – a case study

2019 ◽  
Author(s):  
Louise Chappell-Maor ◽  
Masha Kolesnikov ◽  
Jonathan Grozovski ◽  
Jung-Seok Kim ◽  
Anat Shemer ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Cre Recombinase ◽  
Brain Macrophages ◽  
Technological Advances ◽  
Communication Circuits ◽  
Cell Type Specific ◽  
Definition Of ◽  
The Brain ◽  
Brain Macrophage

AbstractConditional mutagenesis and fate mapping have contributed considerably to our understanding of physiology and pathology. Specifically, Cre recombinase-based approaches allow the definition of cell type-specific contributions to disease development and inter-cellular communication circuits in respective animals models. Here we compared Cx3cr1CreER and Sall1CreER transgenic mice and their use to decipher the brain macrophage compartment as a showcase to discuss recent technological advances. Specifically, we highlight the need to define the accuracy of Cre recombinase expression, as well as strengths and pitfalls of these particular systems that should be taken into consideration when applying these models.

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