AML-214: Case Report: A Rare Case Presentation and Detection of Acute Promyelocytic Leukemia

Abstract Background Management of postoperative chylothorax usually consists of nutritional regimens, pharmacological therapies such as octreotide, and surgical therapies such as ligation of thoracic duct, but a clear consensus is yet to be reached. Further, the variation of the thoracic duct makes chylothorax difficult to treat. This report describes a rare case of chylothorax with an aberrant thoracic duct that was successfully treated using focal pleurodesis through interventional radiology (IVR). Case presentation The patient was a 52-year-old man with chylothorax after a thoracoscopic oesophagectomy for oesophageal cancer. With conventional therapy, such as thoracostomy tube, octreotide or fibrogammin, a decrease in the amount of chyle was not achieved. Therefore, we performed lymphangiography and pleurodesis through IVR. The patient appeared to have an aberrant thoracic duct, as revealed by magnetic resonance imaging (MRI); however, after focal pleurodesis, the leak of chyle was diminished, and the patient was discharged 66 days after admission. Conclusions Chylothorax remains a difficult complication. Focal pleurodesis through IVR can be one of the options to treat chylothorax.

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Phenylketonuria and juvenile idiopathic arthritis: a case report

BMC Pediatrics ◽

10.1186/s12887-021-02602-6 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Ting Ting Zhu ◽

Jin Wu ◽

Li Yuan Wang ◽

Xiao Mei Sun

Keyword(s):

Juvenile Idiopathic Arthritis ◽

Case Report ◽

Autoimmune Diseases ◽

Hip Joint ◽

Metabolic Disorder ◽

Rare Case ◽

Molecular Data ◽

Methotrexate Therapy ◽

Case Presentation

Abstract Background Phenylketonuria (PKU) is a genetic metabolic disorder in which patients have no ability to convert phenylalanine to tyrosine. Several autoimmune diseases have been reported to combine with PKU, co-existent of PKU and Juvenile Idiopathic Arthritis (JIA) has not been presented. Case presentation The girl was diagnosed with PKU at the age of 1 month confirmed by molecular data. At the age of 3.5 years, she presented with pain and swelling of her right ankle, right knee, and right hip joint. After a serial of examinations, she was diagnosed with JIA and treated with a nonsteroidal anti-inflammatory drug. Conclusions We report a rare case of a 4-year-old girl with PKU and JIA, which supports a possible interaction between PKU and JIA. Long-term metabolic disturbance may increase the susceptibility to JIA. Further chronic inflammation could alter the metabolism of tryptophan and tyrosine to increase blood Phe concentration. In addition, corticosteroid and methotrexate therapy for JIA may increase blood Phe concentration.

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Down syndrome with microgranular variant of acute promyelocytic leukemia in a child: a case report

Journal of Medical Case Reports ◽

10.1186/1752-1947-1-147 ◽

2007 ◽

Vol 1 (1) ◽

Cited By ~ 3

Author(s):

Deepali Jain ◽

Tejinder Singh ◽

Prerna Arora

Keyword(s):

Down Syndrome ◽

Case Report ◽

Acute Promyelocytic Leukemia ◽

Promyelocytic Leukemia

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Leptospirosis presenting as severe cardiogenic shock: A case report

Journal of the Intensive Care Society ◽

10.1177/1751143718754993 ◽

2018 ◽

Vol 19 (4) ◽

pp. 351-353

Author(s):

E Forbat ◽

MJ Rouhani ◽

C Pavitt ◽

S Patel ◽

R Handslip ◽

...

Keyword(s):

Case Report ◽

Cardiogenic Shock ◽

Social History ◽

Rare Case ◽

Clinical Course ◽

Unknown Origin ◽

Case Presentation ◽

Pyrexia Of Unknown Origin ◽

Severe Cardiogenic Shock ◽

Infectious Illness

Background Leptospirosis is a rare infectious illness caused by the Spirochaete Leptospira. It has a wide-varying spectrum of presentation. We present a rare case of severe cardiogenic shock secondary to leptospirosis, in the absence of its common clinical features. Case presentation A 36-year-old woman presented to our unit with severe cardiogenic shock and subsequent multi-organ failure. Her clinical course was characterised by ongoing pyrexia of unknown origin with concurrent cardiac failure. She was initially managed with broad-spectrum antibiotics and inotropes. Percutaneous cardiac biopsy excluded major causes of myocarditis. On day 21 after presentation, she was found to be IgM-positive for leptospirosis. Conclusions This is a rare case of severe cardiogenic shock secondary to leptospirosis infection. The case also highlights the importance of obtaining a thorough social history when assessing a patient with an unusual presentation, as clues can often be missed.

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