Comparison of interferon-γ release assay and tuberculin test for screening in healthcare workers

2010 ◽  
Vol 16 (2) ◽  
pp. 211-221
Author(s):  
José Torres Costa ◽  
Rui Silva ◽  
Raul Sá ◽  
Maria João Cardoso ◽  
Carla Ribeiro ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Tuberculin Test ◽  
Interferon Γ ◽  
Release Assay

Use of a T Cell Interferon-γ Release Assay to Evaluate Tuberculosis Risk in Newly Qualified Physicians in Singapore Healthcare Institutions

2009 ◽  
Vol 30 (9) ◽  
pp. 870-875 ◽  
Author(s):  
C. B. E. Chee ◽  
L. K. Y. Lim ◽  
T. M. Barkham ◽  
D. R. Koh ◽  
S. O. Lam ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Latent Tuberculosis ◽  
Risk Groups ◽  
Interferon Γ ◽  
Public Hospitals ◽  
High Rate ◽  
Assay Result ◽  
Release Assay ◽  
Baseline Test ◽  
Tuberculosis Risk

Background.Surveillance for latent tuberculosis in high-risk groups such as healthcare workers is limited by the nonspecificity of the tuberculin skin test (TST) in BCG-vaccinated individuals. The Mycobacterium tuberculosis antigen-specific interferon-γ release assays (IGRAs) show promise for more accurate latent tuberculosis detection in such groups.Objective.To compare the utility of an IGRA, the T-SPOT.TB assay, with that of the TST in healthcare workers with a high rate of BCG vaccination.Methods.Two hundred seven medical students from 2 consecutive cohorts underwent the T-SPOT.TB test and the TST in their final year of study. Subjects with negative baseline test results underwent repeat testing after working for 1 year as junior physicians in Singapore's public hospitals.Results.The baseline TST result was an induration 10 mm or greater in diameter in 177 of the 205 students who returned to have their TST results evaluated (86.3%), while the baseline T-SPOT.TB assay result was positive in 9 (4.3%) of the students. Repeat T-SPOT.TB testing in 182 baseline-negative subjects showed conversion in 9 (4.9%). A repeat TST in 18 subjects with baseline-negative TST results did not reveal any TST result conversion.Conclusions.The high rate of positive baseline TST results in our BCG-vaccinated healthcare workers renders the TST unsuitable as a surveillance tool in this tuberculosis risk group. Use of an IGRA has enabled the detection and treatment of latent tuberculosis in this group. Our T-SPOT.TB conversion rate highlights the need for greater tuberculosis awareness and improved infection control practices in our healthcare institutions.

Interferon-γ release assay for tuberculosis screening of healthcare workers at a Korean tertiary hospital

2010 ◽  
Vol 42 (11-12) ◽  
pp. 943-945 ◽  
Author(s):  
Hye Yun Park ◽  
Kyeongman Jeon ◽  
Gee Young Suh ◽  
O Jung Kwon ◽  
Doo Ryeon Chung ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Tertiary Hospital ◽  
Interferon Γ ◽  
Tuberculosis Screening ◽  
Release Assay

Conversion rates of an interferon-γ release assay and the tuberculin skin test in the serial monitoring of healthcare workers

Infection ◽  
2012 ◽  
Vol 41 (2) ◽  
pp. 511-516 ◽  
Author(s):  
S. Y. Kim ◽  
M. S. Park ◽  
Y. S. Kim ◽  
S. K. Kim ◽  
J. Chang ◽  
...  
Keyword(s):  
Tuberculin Skin Test ◽  
Skin Test ◽  
Healthcare Workers ◽  
Interferon Γ ◽  
Conversion Rates ◽  
Release Assay

scholarly journals Serial testing with the interferon-γ release assay in Portuguese healthcare workers

2010 ◽  
Vol 84 (4) ◽  
pp. 461-469 ◽  
Author(s):  
José Torres Costa ◽  
Rui Silva ◽  
Raul Sá ◽  
Maria João Cardoso ◽  
Albert Nienhaus
Keyword(s):  
Healthcare Workers ◽  
Interferon Γ ◽  
Serial Testing ◽  
Release Assay

A Summary of Meeting Proceedings on Addressing Variability around the Cut Point in Serial Interferon-γ Release Assay Testing

2013 ◽  
Vol 34 (6) ◽  
pp. 625-630 ◽  
Author(s):  
Charles L. Daley ◽  
Randall R. Reves ◽  
Melodie A. Beard ◽  
Jeffrey Boyle ◽  
Richard B. Clark ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Interferon Γ ◽  
Treatment Algorithms ◽  
Laboratory Science ◽  
Serial Testing ◽  
Key Stakeholders ◽  
National Guidance ◽  
Research Findings ◽  
Release Assay ◽  
Positive Results

On June 13, 2012, a group of key stakeholders, leaders, and national experts on tuberculosis (TB), occupational health, and laboratory science met in Atlanta, Georgia, to focus national discussion on the higher than expected positive results occurring among low-risk, unexposed healthcare workers undergoing serial testing with interferon-γ release assays (IGRAs). The objectives of the meeting were to present the latest clinical and operational research findings on the topic, to discuss evaluation and treatment algorithms that are emerging in the absence of national guidance, and to develop a consensus on the action steps needed to assist programs and physicians in the interpretation of serial testing IGRA results. This report summarizes its proceedings.

Evaluation of the interferon-γ release assay in healthcare workers

2007 ◽  
Vol 81 (3) ◽  
pp. 295-300 ◽  
Author(s):  
A. Nienhaus ◽  
A. Schablon ◽  
C. Le Bâcle ◽  
B. Siano ◽  
R. Diel
Keyword(s):  
Healthcare Workers ◽  
Interferon Γ ◽  
Release Assay
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